Effect of Vitamin D Supplementation in Prostate Cancer: A Systematic Review of Randomized Control Trials.
Int J Vitam Nutr Res. 2019 Apr 30:1-13. doi: 10.1024/0300-9831/a000494.
Petrou S1, Mamais I2, Lavranos G3, Tzanetakou IP1, Chrysostomou S1.
- Overview Prostate Cancer and Vitamin D
- Prostate and Urinary systems much better with higher vitamin D – many studies
- Prostate surgery outcomes vary with Vitamin D Receptors– May 2017
- Prostate Cancer might be treated by 4,000 IU of vitamin D and aspirin – RCT 2021
- The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019
- Calcitriol category listing has
62 items along with related searches The Meta-analysis of Prostate Cancer
- 1.5X more likely to die of Prostate Cancer if low vitamin D when initially diagnosed – meta-analysis March 2024
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Variety of Vitamin D forms treat Prostate Cancer – RCT Review April 2019
- Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018
- Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018
- Graphs of Vitamin D and Cancer – meta-analysis Dec 2011
- Risk of Prostate Cancer weakly associated with vitamin D - meta-analysis March 2011
- 16 percent less Prostate Cancer sometimes for each 10 ng vitamin D increase - meta-analysis Jan 2011
- Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010
Prostate Cancer and Omega-3
- 2.5 X reduced risk of cancer in 70 year-olds by a small amount of Vitamin D, Omega-3 and exercise – RCT April 2022
- Prostate Cancer PSA reduced by 60 ng of Vitamin D, Vitamin B complex, Omega-3, Curcumin and diet – June 2021
- Men with High Omega-3 ratio 3 times less likely to have high grade prostate cancer – July 2019
- Low-Grade Prostate Cancer 70 percent less likely to progress if good level of Omega-3 – June 2018
- Prostate Cancer treatment (Vitamin D, Omega-3, Tumeric) RCT ending Dec 2018
Vitamin D is important in many cellular functions including cell cycling and proliferation, differentiation, and apoptosis. Via the induction of cell cycle arrest and/or apoptosis, vitamin D inhibits normal prostatic epithelial cells growth. Review the evidence of the effect of vitamin D supplementation on prostate cancer (PC) biomarkers and patient survival and assess optimal dosage, formulation and duration. Pubmed, Medline and Ebsco Host databases were systematically searched for relevant literature. 8 Randomized Controlled Trials were included in this review. All studies, besides one, were of high methodological quality.- 4 studies used calcitriol (0,5-45 pg/weekly),
- 2 studies have used vitamin D3 (150-1000 μg/daily) and
- 2 other studies have used 1α-hydroxy Vitamin D2 (10 μg/daily or weekly).
Duration of supplementation varied between 28 days up to 18.3 months.
- Two studies had positive effects on prostate specific antigen (PSA) (p < .05),
- 1 study had a significant positive effect on median survival (p < .05) and
- 1 study showed a significant reduction of vitamin D receptor (VDR) expression (p < .05).
The remaining studies showed negative or no effect on PC characteristics, clinical outcomes and/or survival. Current evidence suggests that vitamin D supplementation in conjunction with standard of care (e.g. chemotherapy, radiation therapy) may confer clinical benefits such as a decrease in serum PSA levels and VDR expression but further research is required to ascertain these results. Calcitriol supplementation in doses ranging from 250-1000 mg for 3-8 weeks or a lower dose of 45 mg for 18.3 months, appear most beneficial regarding outcomes of PC progression and survival.
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