Tuberculosis treatment helped a bit by a bit of Vitamin D - RCT Feb 2022

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Effects of Vitamin D supplementation on resolution of fever and cough in children with pulmonary tuberculosis: A randomized double-blind controlled trial in Indonesia

J Glob Health. 2022 Feb 18;12:04015. doi: 10.7189/jogh.12.04015. eCollection 2022.
Lianda Tamara 1 2, Cissy B Kartasasmita 1, Anggraini Alam 1, Dida A Gurnida 1

Vitamin D levels did not drop as much in those getting 1,000 IU

Background: Various studies in adults have shown a strong association between vitamin D and tuberculosis (TB), both in terms of vitamin D status and the benefits of vitamin D in managing TB. Studies on vitamin D and its relationship with childhood TB still lack in Indonesia as a country with the second-highest TB incidence globally. This study evaluated the effect of vitamin D supplementation on resolution of cough and fever in Indonesian children with pulmonary TB.

Methods: We conducted a randomized controlled trial of vitamin D supplementation in children with pulmonary TB and vitamin D insufficiency. Patients were randomly allocated with 1:1 ratio to receive either 1000 IU vitamin D or placebo daily after starting standard TB treatment. The primary outcome in this study was the resolution of fever and cough symptoms reviewed weekly after starting the treatment until the symptoms are resolved. The secondary outcome in this study was 25-hydroxyvitamin D serum level and nutritional status which was reviewed at the end of the trial. Intention to treat analyses were applied. Differences in clinical outcomes between two groups were calculated using Mann-Whitney U test or χ2 test, where appropriate.

Findings: A total of 84 patients met the inclusion criteria, aged 6 to 18 years old, newly diagnosed with pulmonary TB and vitamin D insufficiency. Eighty patients (95,2%) completed the six months follow-up. Faster resolution of fever, cough, improved malnutrition status, and higher vitamin D level were found in the intervention group compared to the placebo group (all P < 0.001).

Conclusions: Vitamin D is beneficial in improving fever and cough resolution, and improving nutritional status in children with pulmonary TB and vitamin D insufficiency. Determination of adequate supplementation levels of more than 1000 IU requires further research to achieve normal vitamin D levels during the duration of treatment for pulmonary TB in children.

Trial registration: ClinicalTrials.gov (NCT05073965).
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VitaminDWiki - Tuberculosis category

125 Tuberculosis studies:    15 RCT,   14 Meta-analyses,  8 Vitamin D Receptor

• TB patients had low Vitamin D and poor Vitamin D receptor – June 2019
• Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017
  • Receptor-related diseases respond especially well to high-dose Vitamin D
• Pulmonary Tuberculosis 2X more likely if poor Vitamin D Receptor (Mexico) – April 2018
• TB not prevented by a small amount of Vitamin D (2,000 IU daily average, Mongolia) – RCT July 2020
• Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
• Latent Tuberculosis 44 percent less likely if Vitamin D more than 30 ng - 14th meta-analysis Jan 2022
• Tuberculosis (multi-drug resistant) was 13.4 X more likely to be quickly cleared with Vitamin D - Meta-analysis Feb 2019
• No tuberculosis if more than 80 ng of vitamin D (cattle) - Jan 2022

see also Overview Tuberculosis and Vitamin D    Breathing category
TB has been increasing

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VitaminDWiki - Youth category

Youth category listing has 175 items which includes:

• Vitamin D for Adolescents - review 2019
• Vitamin D levels in teens restored with 150,000 IU monthly for 3 months (mean 33 ng) – Oct 2021
• 2,000 IU of vitamin D daily helped 80 percent of adolescents – Dec 2020
• Do teens need just 10 ng or up to 60 ng of vitamin D – Review Nov 2019
• Metabolic Syndrome in Chinese youths 2.5 X more likely if less than 20 ng of vitamin D – Sept 2018
• Low levels of Vitamin D in UAE juveniles (virtually none had 30 ng) – Jan 2018
• Reasons for children having low vitamin D (proposed by 10 societies) - May 2018
• Vitamin D restored in teens by doses totalling 300,000 IU – Nov 2014
• Multiple Sclerosis increasing in teens – at least 2X in 9 years
• Majority of adolescents have far less than optimum vitamin D levels – Oct 2017
• Many US kids have less than 40 ng of Vitamin D – 99 out of 100 blacks, 91 out of 100 whites – Jan 2017
• Takes a year to restore children and youths to good levels of vitamin D without loading dose - RCT Dec 2016
• Slow walking speed of youths 14 times more likely if low vitamin D - Dec 2016