Vitamin D supplementation protects against reductions in plasma 25-hydroxyvitamin D induced by open-heart surgery: Assess-d trial
Physiol Rep. 2021 Feb;9(3):e14747. doi: 10.14814/phy2.14747.
Tyler Barker 1 2, Heidi T May 3, John R Doty 3 4, Donald L Lappe 3 4, Kirk U Knowlton 3 4, John Carlquist 3, Kristin Konery 3, Shannon Inglet 3, Ben Chisum 3, Oxana Galenko 3, Jeffrey L Anderson 3 4, Joseph B Muhlestein 3 4
This study gave 50,000 IU of vitamin D the night before and the 2 days after the surgery
There would probably be more benefit to the body
if the same amount were given several days before the surgery,
as it takes the body a while to utilize the vitamin D
>200.000 IU total in the week before a surgery would be good
- Half as many problems if take Vitamin D (300,000 IU) before thyroidectomy – RCT Jan 2021
- Improve your health BEFORE surgery (prehabilitation) helps your recovery - 2018
- '':In many cases taking Vitamin D years before would have elminated the need for the surgery
- Vitamin D is needed before most surgeries – many studies and RCTs
Trauma and surgery category starts with the following
Trauma and Surgery category hasLarge dose Vitamin D before surgery was found to help by 35 studies
Vitamin D is needed before most surgeries – many studies and RCTs
4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
Sepsis is both prevented and treated by Vitamin D - many studies
Thyroidectomy and Vitamin D - many studies
Orthopaedic surgeries need Vitamin D – many studies
Cancer - After diagnosis chemotherapy
TBI OR "Traumatic Brain Injury - 21 in title as of Sept 2022
Superbug (Clostridium difficile) Infections strongly associated with low vitamin D - many studies
Glutamine and Omega-3 have also been proven to help several traumas/surgeries
Note: Vitamin D also prevents the need for various surgeries and Omega-3 prevents many concussions/TBI
Trauma and Surgery is associated with 22 other VitaminDWiki categories
Such as loading dose 33, Mortality 23, Infant-Child 21 Intervention 19 Cardiovascular 13, Injection 13 in Sept 2022
Personal note: 200,000 IU vitamin D helped my 100 year old in ICU
My 100 year-old father-in-law had sepsis while in the ICU
I gave him 200,000 IU of vitamin D - without the doctor's knowledge
He was kicked out of the ICU and hospital 3 days later - sepsis gone and he was all recovered
Download the PDF from VitaminDWiki
150,000 IU given late showed minimal benefit
Low vitamin D (serum or plasma 25-hydroxyvitamin D OH)D is a global pandemic and associates with a greater prevalence in all-cause and cardiovascular mortality and morbidity. Open-heart surgery is a form of acute stress that decreases circulating 25(OH)D concentrations and exacerbates the preponderance of low vitamin D in a patient population already characterized by low levels. Although supplemental vitamin D increases 25(OH)D, it is unknown if supplemental vitamin D can overcome the decreases in circulating 25(OH)D induced by open-heart surgery. We sought to identify if supplemental vitamin D protects against the acute decrease in plasma 25(OH)D propagated by open-heart surgery during perioperative care.
Participants undergoing open-heart surgery were randomly assigned (double-blind) to one of two groups: (a) vitamin D (n = 75; cholecalciferol, 50,000 IU/dose) or (b) placebo (n = 75). Participants received supplements on three separate occasions: orally the evening before surgery and either orally or per nasogastric tube on postoperative days 1 and 2. Plasma 25(OH)D concentrations were measured at baseline (the day before surgery and before the first supplement bolus), after surgery on postoperative days 1, 2, 3, and 4, at hospital discharge (5-8 days after surgery), and at an elective outpatient follow-up visit at 6 months.
Supplemental vitamin D abolished the acute decrease in 25(OH)D induced by open-heart surgery during postoperative care. Moreover, plasma 25(OH)D gradually increased from baseline to day 3 and remained significantly increased thereafter but plateaued to discharge with supplemental vitamin D. We conclude that perioperative vitamin D supplementation protects against the immediate decrease in plasma 25(OH)D induced by open-heart surgery. ClinicalTrials.gov Identifier: NCT02460211.
| 9085 visitors, last modified 13 Nov, 2022, |
| ID | Name | Uploaded | Size | Downloads | |
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| 15045 | Open Heart Table 6.jpg | admin 14 Feb, 2021 | 64.24 Kb | 386 | |
| 15044 | Before surgery.jpg | admin 14 Feb, 2021 | 45.87 Kb | 431 | |
| 15043 | Before open-heart.pdf | admin 14 Feb, 2021 | 536.99 Kb | 361 |