Severe COVID while pregnant - none had taken any vitamin D – Oct 2021

Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study

J Steroid Biochem Mol Biol . 2021 Oct;213:105964. doi: 10.1016/j.jsbmb.2021.105964
Selcan Sinaci 1, Doga Fatma Ocal 2, Didem Fatma Yucel Yetiskin 2, Derya Uyan Hendem 2, Gul Nihal Buyuk 2, Sule Goncu Ayhan 2, Atakan Tanacan 2, A Seval Ozgu-Erdinc 2, Ozlem Moraloglu Tekin 3, Dilek Sahin 3
Affiliations expand

Objective: We aimed to evaluate the vitamin D status of pregnant women with COVID-19, and the association between vitamin D level and severity of COVID-19.

Methods: In this case control study, 159 women with a single pregnancy and tested positive for SARS-CoV-2, and randomly selected 332 healthy pregnant women with similar gestational ages were included. COVID-19 patients were classified as mild, moderate, and severe. Vitamin D deficiency was defined as 25-hydroxycholecalciferol <20 ng/mL (50 nmol/L), and 25-OH D vitamin <10 ng/mL was defined as severe vitamin D deficiency, also 25-OH D vitamin level between 20-29 ng/mL (525-725 nmol/L) was defined as vitamin D insufficiency.

Results: Vitamin D levels of the pregnant women in the COVID-19 group (12.46) were lower than the control group (18.76). 25-OH D vitamin levels of those in the mild COVID-19 category (13.69) were significantly higher than those in the moderate/severe category (9.06). In terms of taking vitamin D supplementation, there was no statistically significant difference between the groups. However, it was observed that all of those who had severe COVID-19 were the patients who did not take vitamin D supplementation.

Conclusion: The vitamin D levels are low in pregnant women with COVID-19. Also, there is a significant difference regarding to vitamin D level and COVID-19 severity in pregnant women. Maintenance of adequate vitamin D level can be useful as an approach for the prevention of an aggressive course of the inflammation induced by this novel coronavirus in pregnant women.
 Download the PDF from VitaminDWiki

Clipped from PDF

There was no statistically significant relationship between vitamin D supplementation and COVID-19 severity (p > 0.05). However, it was observed that all of those who had severe COVID-19 were the patients who did not take vitamin D supplementation.
In those taking vitamin D supplementation, the mild COVID-19 rate was 77.8 %; while moderate and severe was 22.2 %, as seen in Table 6.

VitaminDWiki – 25 studies in both categories Virus and Pregnancy

This list is automatically updated

VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of March 31, 2024, the VitaminDWiki COVID page had:  trial results,   meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
5 most-recently changed Virus entries

see also some Virus interventions and meta-analyses in VitaminDWiki

Interventions

• 21 fewer days in hospital with ARDS (COVID) if 10,000 IU of Vitamin D daily after enter hospital – RCT April, 2022
• 4X less likely to get COVID following 4,000 IU daily for a month – RCT April 2022
• Group achieving 30 ng (vs 26 ng) were 2X less likely to get COVID symptoms - RCT Jan 2022
• COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021

Meta-analyses

• COVID test positive is about half as likely if have Vitamin D – 24th meta-analysis - Jan 2022
• Vitamin D fights COVID (54 studies of 1,400,000 people) – 23rd meta-analysis - Dec 2021
• COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis - Dec 29, 2021

VitaminDwiki - Pregnancy category

 - see also

• Overview Pregnancy and vitamin D
• Number of articles in both categories of Pregnancy and:Dark Skin 30;   Depression 21;   Diabetes 44;   Obesity 17;  Hypertension 44;   Breathing 36;  Omega-3 44;  Vitamin D Receptor 24 Click here for details
• All items in category Infant/Child 854 items
• Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
• 38+ papers with Breastfed etc, in the title
• Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
• 53+ preeclampsia studies
• 94+ studies with PRETERM in the title
• Fertility problem (PCOS) reduced by vitamin D, etc: many studies 15+
• 94+ Gestational Diabetes
• Caesarean birth much more likely if low Vitamin D - many studies 15+ studies
• Post-partum depression and low Vitamin D - many studies 15+ studies
• Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies 5+ studies
• Search VitaminDWiki for "Assisted reproduction" 33 items as of Aug 2022
• Fertility and Sperm category listing has 142 items along with related searches
• (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
• Less labor pain if higher level of vitamin D – August 2021
• Healthy pregnancies need lots of vitamin D
• Ensure a healthy pregnancy and baby - take Vitamin D before conception