Review of autoimmune skin diseases and Vitamin D ignores topical form -Nov 2022

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The role of VD/VDR signaling pathway in autoimmune skin diseases

Mini Rev Med Chem . 2022 Nov 24. doi: 10.2174/1389557523666221124123206   PDF is behind a $95 paywall
Yilan Zeng 1 , Shengbo Yang 1 , Dan Wang 1 , Yuanhong Liu 1 , Ziting Tang 1 , Xuemei Li 1 , Xiule Zong 1

Background: Immune-related cutaneous diseases are a series of disorders, such as

• alopecia areata,
• psoriasis,
• atopic dermatitis,
• systemic lupus erythematosus and
• autoimmune bullous dermatoses.

Vitamin D is a fat-soluble vitamin, which is known for its classical pleiotropic effect. Recent studies have found that vitamin D, after catalyzed into its biologically active form [1,25OH 2D], correlated with its receptor, vitamin D receptor, plays a vital role in multiple pathophysiological processes, including immune-related dermatoses. This review mainly summarizes evidence on the role of vitamin D/vitamin D receptor in immune-related cutaneous diseases and the potential therapeutic targets for skin disorders.

Methods: We have carried out a comprehensive literature search in PubMed and Google Scholar databases using keywords like "vitamin D", "vitamin D receptor", "immune", "psoriasis", "atopic dermatitis", "skin", "systemic lupus erythematosus", "alopecia areata" and "autoimmune bullous dermatoses". Only articles related to the topic were included in this review. Conference, patent, graduation thesis and articles without available full text were excluded.

Results: Vitamin D/vitamin D receptor is critical for skin in regulating the proliferation and differentiation of keratinocytes, keeping the integrity of the skin barrier as well as maintaining the homeostasis of the skin's immune system. Vitamin D deficiency/vitamin D receptor mutations are potential risk factors for some immune-related cutaneous diseases.

Conclusion: Vitamin D is a pleiotropic hormone, which is important in the homeostasis of human body. Many studies have revealed vitamin D deficiency in several skin diseases. Thus, vitamin D supplementation may be a useful therapeutic option for immune-related skin diseases.

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VitaminDWiki - Topical Vitamin D contains

Topical is one of the many ways of increasing the vitamin D in your body
Topical is 2X to 50X more expensive than oral form
Topical is great for those who not want to swallow pillls nor fortifiy their food/drink with Vitamin D
Topical is one of the many gut-friendly forms of vitamin D (good bioavailability for those with poor guts
Topical is especially good form to apply directly to skin problems:
    - i.e. Psoriasis  Warts  Burns  Acne  Eczema  Wounds  (lasts about a day)
    The skin, like most tissues of the body, can fully-activate Vitamin D locally - no liver nor kidney needed.
Provides perhaps 100X higher concentration of Vitamin D to that portion than if same dose were taken orally
There were 98 topical Vitamin D products on Amazon Sept 2024 Creams, oils, patches, nanoemulsions, etc.
   I prefer Nutrasal nanoemulsion form
Suspect that topical Vitamin D is best absorbed where the skin gets Vitamin D naturally
- - - face and hands vs the back or the inside of arms
Nanoemulsions can also be applied topically under the tongue and inhaled

• - - - - and, as of Nov 2022 - - - - -

• Overview Skin and vitamin D
• Topical Vitamin D provides more benefits than oral sometimes - many studies
• Psoriasis paradigm shift – use topicals, like Vitamin D – Aug 2021
• Topical Vitamin D provides more benefits than oral for some people
• Skin category listing has 122 items along with related searches
• Topical vitamin D raised blood level to 38 ng (used Aloe Vera gel) – RCT March 2014
• Topical vitamin D might be more bio-available than oral – Oct 2015
• Off topic: Transcutaneous enhancers (DMSO, etc) for Vitamin D, Vitamin C, Resveratrol, Magnesium, etc.
• Getting Vitamin D into your body topical is one of many ways

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VitaminDWiki – Psoriasis category contains

Some of the 72 Psoriasis articles

• Psoriasis is most strongly associated with low vitamin D (15 things were evaluated) – July 2022
• Long-term Psoriasis cured by 30,000 to 60,000 IU of Vitamin D daily (pictures and video) – early 2022
• Psoriasis paradigm shift – use topicals, like Vitamin D – Aug 2021
• Low Vitamin D plus psoriasis equals 8 times more likely to die – Dec 2020
• UV has treated psoriasis for over a century, guidelines finally agreed upon – Aug 2019
• Psoriasis severity associated with low vitamin D (10 studies) – meta-analysis Jan 2018
• Psoriasis reduced for those getting Vitamin D levels above 50 ng – RCT Feb 2018
• 35,000 IU vitamin D daily for 6 months helped ALL psoriasis suffers (106 ng) – Brazil March 2013

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VitaminDWiki – Lupus category contains

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VitaminDWiki – Atopic Dermatitis and Eczema - many studies

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VitaminDWiki – Spot Baldness (Alopecia Areata) associated with low vitamin D – many studies