Preinduction Serum Vitamin D3 Levels and Induction Chemotherapy Remission Rates in Patients with Acute Leukemia
Nutrition and Cancer – https://doi.org/10.1080/01635581.2022.2077389 PDF behind paywall
Shweta Maurya. Anil Kumar Tripathi, Shailendra Prasad Verma
Vitamin D deficiency(<20 ng/mL) is a common condition, associated with an inferior prognosis in some cancers. However, the prognostic significance of vitamin D deficiency in acute leukemia is largely unknown. The present study aimed to assess the baseline status of vitamin D [25-(OH) D3] and find its association with induction remission rate and mortality using standard chemotherapy in patients with acute leukemia. In this prospective observational study, blood samples were collected from 73 newly diagnosed patients before starting induction chemotherapy to measure serum vitamin D [25(OH)D] levels along with routine investigations.44/73 (60.3%) patients were acute lymphoblastic leukemia (ALL), and 29/77 (39.7%) were acute myeloid leukemia (AML) patients. Descriptive statistics and frequency distribution were used in SPSS software, and Pearson’s chi-squared test compared the categorical variables. Post-induction remission status (complete and incomplete remission) and induction-related mortality were correlated with vitamin D levels. 44/73 patients (60.3%) included in this study were males, and the remaining were females. The mean age of the participants was 30.32 ± 14.95 years. The mean serum vitamin D level in the cohort was 15.74 ± 28.14 ng/mL. Vitamin D deficiency was observed in 59/73 (80.8%) patients, whereas 14/73 (19.2%) had normal levels (≥20ng/mL) of the vitamin. Vitamin D deficiency is common among acute leukemia patients. Herein, we observed that low vitamin D level is associated with higher rates of incomplete remission in acute leukemia patients (P = 0.016). Vitamin D deficiency is common among acute leukemia patients and is associated with poor short-term outcomes.
VitaminDWiki pages with CHEMOTHERAPY in title (27 as of Aug 2022)
This list is automatically updated
Items found: 30
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Cisplatin-Based chemotherapy greatly increased by vitamin D supplementation - Dec 2023 |
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16 Aug, 2024 |
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Breast Cancer chemotherapy improved if able to suppress a vitamin D gene (CYP24A1) – May 2023 |
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18 Mar, 2023 |
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Chemotherapy might be amplified by vitamin D |
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05 Mar, 2023 |
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Chemotherapy and vitamin D - many studies |
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05 Mar, 2023 |
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Poor chemotherapy results if low vitamin D (leukemia in this case) – May 2022 |
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17 Aug, 2022 |
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Trial: Can 50,000 IU of Vitamin D weekly help with Breast Cancer Chemotherapy - Early 2021 |
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21 Dec, 2020 |
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3X reduction in Chemotherapy dose by Photodynamic Priming of Vitamin D Receptor (mice) – March 2020 |
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30 Mar, 2020 |
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Chemotherapy hair loss – prevented or treated by Vitamin D, US patent application – Nov 2019 |
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24 Nov, 2019 |
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increased Chemotherapy survival if OK vitamin D (Hodgkin Lymphoma 1.8 X in this study) – Nov 2019 |
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20 Nov, 2019 |
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Relapses of Acute Lymphoblastic Leukemia (ALL) – 1 in 5 are due to genes mutated by chemotherapy – Nov 2019 |
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10 Nov, 2019 |
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Omega-3 reduced by 4X the interruption of Cervical Cancer chemotherapy due to toxicity – RCT June 2019 |
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18 Jun, 2019 |
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Chemotherapy for Breast Cancer lowers Vitamin D levels – Oct 2018 |
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25 Sep, 2018 |
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Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018 |
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21 Aug, 2018 |
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Chemotherapy drugs often reduce Vitamin D levels, restoring levels helps– Aug 2018 |
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16 Aug, 2018 |
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Cisplatin chemotherapy dose size might be reduced by Omega-3 – Jan 2018 |
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06 Jan, 2018 |
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Breast Cancer chemotherapy 2.7 X less likely to work if low vitamin D – Dec 2017 |
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22 Dec, 2017 |
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Breast Cancer Chemotherapy initially decreases vitamin D levels – May 2012 |
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13 Dec, 2017 |
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Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017 |
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13 Dec, 2017 |
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Cancer Chemotherapy and vitamin D – Review March 2013 |
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14 Jul, 2017 |
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Chemotherapy might be augmented with Vitamin D – Jan 2017 |
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14 Jul, 2017 |
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Breast Cancer Chemotherapy dropped Vitamin D levels by 6 nanograms – Nov 2015 |
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14 Jul, 2017 |
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Hypothesis – Chemotherapy can be aided by Vitamin D – March 2016 |
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14 Jul, 2017 |
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Breast cancer chemotherapy benefits from highest vitamin D levels – June 2014 |
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03 Mar, 2016 |
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Off Topic: Cannabinoids as Cancer chemotherapy – Sept 2014 |
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26 Jan, 2016 |
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If vitamin D levels were not changed, toxicity to chemotherapy did not vary with levels – May 2012 |
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11 Jan, 2016 |
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Aromatase inhibitor chemotherapy after breast cancer not associated with vitamin D levels – Dec 2011 |
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24 May, 2015 |
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Vitamin D2 patent granted to prevent hair loss during chemotherapy – 2002 |
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11 May, 2015 |
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Chemotherapy (cisplatin) and vitamin D synergistically stop stomach cancer – Feb 2014 |
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28 Feb, 2014 |
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Vitamin D levels dropped 3 ng during cancer chemotherapy – May 2012 |
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08 Jan, 2014 |
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Vitamin D Shows Potential in Natural Chemotherapy April 2010 |
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30 Apr, 2010 |
VitaminDWiki pages with CHEMO in title (10 as of Aug 2022)
This list is automatically updated
Items found: 11
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New Nanomedicine Delivers Chemo Drugs Directly to Tumors (wonder if it could deliver Vitamin D) - Sept 2024 |
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23 Sep, 2024 |
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Vitamin D, Gut Microbiota, and Chemo-radiation interactions – Dec 2019 |
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25 Feb, 2021 |
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4X less of one chemo needed after vitamin D receptor activation - June 2020 |
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02 Jun, 2020 |
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Breast cancer chemo made more women vitamin D insufficient, even 6 months later– 2019 |
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12 May, 2020 |
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Improved long-term chemo survival if good Vitamin D (1.8 X better - Hodgkin Lymphoma) – Oct 2019 |
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27 Nov, 2019 |
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Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 2019 |
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07 Sep, 2019 |
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Chemo only as needed for Prostate Cancer is working well - March 2019 |
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28 Mar, 2019 |
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Chemo-mouth (oral mucositis) subtantially reduced by daily 1,000 IU of vitamin D – June 2017 |
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06 Nov, 2017 |
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Chemo reduced leukemia patients vitamin D levels – Jan 2013 |
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08 Jan, 2017 |
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Chemo drug (Nitrogen Mustard in this study) side effects minimized by vitamin D (mice) – March 2015 |
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03 Mar, 2016 |
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Hypothesis: Chemo brain and other cognitive impairements are associated with low vitamin D |
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09 Jul, 2014 |
See also in VitaminDWiki
Overview Leukemia and Vitamin D
Chemotherapy and vitamin D - many studies
Increased Vitamin D might allow decreased Chemotherapy
Chart by VitaminDWiki
Warning: Vitamin D can increase Chemo potency - possible death if chemo dose is not reduced