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Pathways that vitamin D prevents and treats colon cancer discovered, 2000 IU needed – Dec 2012

Using components of the vitamin D pathway to prevent and treat colon cancer.

Nutr Rev. 2012 Dec;70(12):721-9. doi: 10.1111/j.1753-4887.2012.00522.x. Epub 2012 Oct 12.
Stubbins RE, Hakeem A, Núñez NP.
Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA.

The objective of this review was to analyze the components of vitamin D and their potential usefulness in preventing and treating colorectal cancer. The active form of vitamin D, 1α,25(OH(2) )D(3) , targets the wnt/β-catenin pathway by upregulating key tumor suppressor genes such as E-cadherin, which promotes an epithelial phenotype, but this is only possible when the vitamin D receptor (VDR) is present. Colorectal cell lines have shown that VDR expression levels decrease in the later stages of colon cancer. In colorectal cancers with low VDR expression, treatments to increase VDR expression could target alterations at the genomic and epigenomic levels by modulating transcription factors such as SNAIL1 and by utilizing histone deacetyltransferase inhibitors, respectively.

Finally, epidemiological studies suggest that the current US Recommended Dietary Allowance should be increased to 2,000 IU in order to raise serum 25(OH)D(3) levels above 30 ng/mL. This increase in vitamin D status can be obtained most efficiently from sun exposure or vitamin D supplementation. In summary, vitamin D and its metabolites could be utilized in strategies to treat and prevent colon cancer.

© 2012 International Life Sciences Institute.

PMID: 23206285

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Pathways that vitamin D prevents and treats colon cancer discovered, 2000 IU needed – Dec 2012

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- Overview Cancer-Colon and vitamin D When advanced Colon Cancer is not treated by Vitamin D – Mar 2012 Hypothesis: low vitamin D increases probability of colon cancer – May 2013 Vitamin D Wiki News for Dec 2012 and Jan 2013 Colorectal Cancer and Vitamin D infographic

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