Serum 25-hydroxyvitamin D, frailty, and mortality among the Chinese oldest old: Results from the CLHLS study
Nutr Metab Cardiovasc Dis. 2021 Aug 26;31(9):2707-2715. doi: 10.1016/j.numecd.2021.05.033
Lin Liu 1, Chaolei Chen 1, Kenneth Lo 2, Jiayi Huang 1, Yuling Yu 1, Yuqing Huang 3, Yingqing Feng 4
Mortality category starts with:
People die sooner if they have low vitamin D
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- More vitamin D means fewer deaths – many studies
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
- Dr. Grant on vitamin D and mortality in VitaminDWiki
- Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
- Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- 4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
- Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
- Senior women having low vitamin D were 2X more likely to die - Sept 2023
- Risk of death after bone fracture was 6.6 X higher if less than 10 ng of vitamin D – June 2017
Items in both categories Seniors and Morality
- Seniors 5.4 more likely to die if Vitamin D less than 15 ng (Mexico) – Aug 2023
- Longevity and healthspan increased by Vitamin D, Omega-3, Magnesium - many studies
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- Only 35,000 died in US of COVID who previously had been healthy
- Oldest Chinese with low Vitamin D were more likely to die – Oct 2021
- 40 percent less likely to die if vitamin D was prescribed (10,000 VA patients, no surprise) – Oct 2021
- Vitamin D supplementation and high levels reduce COVID-19 deaths in elderly – Review April 17, 2021
- 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
- Respiratory deaths in seniors – 40 percent are attributable to low vitamin D – Aug 2020
- Vitamin D predicts good health and long life in seniors, review of 20 cohort studies – Oct 2019
- 2 X more likely to die early if low vitamin D (80 year old Chinese) – April 2019
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- Vitamin D In Older Women - Fractures, Frailty and Mortality – Buchebner thesis 2017
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- Vitamin D supplementation can cost 50 dollars a day (live longer)
- Women very low on vitamin D were 56 percent more likely to die in nursing home – Feb 2012
- Vitamin D Omega 3 and Exercise are being used in controlled trial to support healthy ageing – Feb 2012
- Low vitamin D associated with all-cause mortality and frailty – Mar 2011
- Vitamin D deficiency was the best predictor of older patient death in hospital – May 2010
- Table of outcomes for seniors vs vitamin D level
Frailty and Vitamin D - many studies
Download the PDF from VitaminDWiki
Background and aims: In this study, the aim is to explore whether frailty status modified the associations of serum 25(OH)D levels with all-cause and cause-specific mortality in the oldest old Chinese population.
Methods and results: A total of 1411 participants aged at least 80 years were enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Information on serum 25(OH)D level, frailty status, and covariates were examined at baseline. All-cause and cause-specific mortality status were ascertained during the follow-up survey conducted in 2017-2018 by using the ICD-10 codes. Cox proportional hazard models with stratified analyses were performed to evaluate potential associations. Over a median follow-up of 3.2 years, 722 (51.2%) participants were deceased, including 202 deaths due to circulatory diseases, and 520 deaths due to noncirculatory causes.
After multivariable adjustment, the lowest quartile of serum 25(OH)D levels (Hazard Ratios (95% Confidence Intervals), 1.85 (1.45-2.36), 1.85 (1.45-2.36), 1.73 (1.31-2.29), respectively) and frailty (Odd Ratios (95% Confidence Intervals), 1.91 (1.60-2.29), 2.67 (1.90-3.74), 1.64 (1.31-2.05)) were associated with significantly higher risk of all-cause mortality, circulatory mortality, and noncirculatory mortality, respectively.
In addition, we observed significant interactions among 25(OH)D and frailty on the risk of all-cause and cause-specific mortality (all P-interaction < 0.001). Similar results were found in sensitivity analyses by excluding participants who died in the first year of follow-up and using clinical cutoffs of serum 25(OH)D levels.
Conclusion: Low serum 25(OH)D levels were associated with higher risk of all-cause and cause-specific mortality among the oldest old of the Chinese population, and the associations were significantly stronger in individuals with frailty.
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