Men 2X more likely to get pancreatic cancer if low Vitamin D food intake – Nov 2010

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Vitamin D, calcium, and retinol intake, and pancreatic cancer in a population-based case-control study in the San Francisco Bay area.

Cancer Causes Control. 2010 Nov 12.
Zablotska LB, Gong Z, Wang F, Holly EA, Bracci PM.
Department of Epidemiology and Biostatistics, University of California San Francisco, Box 1228, 3333 California Street, Suite 280, San Francisco, CA, 94118, USA, lydia.zablotska at ucsf.edu.

OBJECTIVE: The aim of this study was to evaluate a complex association among intake of dietary vitamin D, calcium, and retinol, and pancreatic cancer risk.

METHODS: Pancreatic cancer cases (n = 532) diagnosed in 1995-1999 were identified using rapid case ascertainment methods and were frequency matched to population-based controls (n = 1,701) in the San Francisco Bay Area. Detailed dietary data were collected during in-person interviews using a validated semi-quantitative food-frequency questionnaire. Adjusted unconditional logistic regression was used to estimate odds ratios (ORs) and confidence intervals.

RESULTS: In men, increased pancreatic cancer risk was associated with currently recommended dietary vitamin D intake levels (highest (>450 IU/day) vs. lowest (<150 IU/day) intake, OR = 2.6, trend-p = 0.009) and total vitamin D intake from diet and supplements (for <800 IU/day). ORs for dietary vitamin D intake remained increased after adjustment for intake of retinol and calcium, although confidence intervals included unity. Stratified analyses showed that ORs were higher among men with lower intake of retinol and lower physical activity but there was no evidence of statistical interaction. No associations with vitamin D intake were observed among women, although ORs typically were elevated. ORs increased with increased dietary calcium intake among men (trend-p = 0.008) and not women.

CONCLUSIONS: Our results among men showing an increased risk of pancreatic cancer associated with dietary intake of vitamin D and of calcium require confirmation in further studies. Continued investigation is needed to clarify the complex role of vitamin D and calcium in pancreatic cancer risk and to determine their optimal intake level and preventive effects for pancreatic cancer. PMID: 21072578

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VitaminDWiki – Cancer category contains: (mainly Vitamin D)

• Cancer 295 items Overview Cancer and vitamin D
• Cancer and Vitamin D - many studies
• After Cancer Diagnosis 113 items
• Bladder Cancer 28 items
• Breast Cancer 259 items Overview Breast Cancer and Vitamin D
• Colon Cancer 145 items Overview Cancer-Colon and vitamin D
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• Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
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• 8 ways that Cancer might be prevented by Vitamin D - June 2019
• Cancer stem cells and Vitamin D - many studies
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• Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
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• Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
• Melanoma 25 X more likely if low vitamin D – Feb 2018
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Cancers get less Vitamin D when there is a poor Vitamin D Receptor

• Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
• Cancer and the Vitamin D Receptor, a primer – Sept 2017
• Vitamin D Receptor (Cancers OR Viruses) - many studies
• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
• Cancer (general) and VDR 23 articles
• Breast Cancer and VDR 24 articles
• Colon Cancer and VDR 13 articles
• Prostate Cancer and VDR 7 articles
• Skin Cancer and VDR 10 articles
  • Note some Health problems, such as some Cancers, protect themselves
    by actively reducing Receptor activation

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