Correction of Low Vitamin D Improves Fatigue: Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study).
N Am J Med Sci. 2014 Aug;6(8):396-402. doi: 10.4103/1947-2714.139291.
Roy S1, Sherman A1, Monari-Sparks MJ1, Schweiker O1, Hunter K2.
| Before | After | |
| Physical | 8 | 3 |
| Emotional | 9 | 5 |
| Mental | 8 | 6 |
| Vigor | 8 | 10 |
| Total Score | 32 | 11 |
| Vitamin D | 20 ng | 52 ng |
Expect similar results of spread if spread over 1 week
Expect much better results with same dose if use Vitamin D3
BACKGROUND:
Fatigue is a common presenting complaint of patients in the primary care offices. Low levels of vitamin D have been associated with fatigue in cancer patients. Normalization of vitamin D level improves their fatigue. Whether low vitamin D plays a role in fatigue in medically stable patients is not known.
AIMS:
This prospective non-randomized therapeutic study observed the prevalence of low vitamin D in fatigue and the effect of normalization of vitamin D on fatigue.
MATERIAL AND METHODS:
One hundred and seventy four adult patients, who presented in our primary care office with fatigue and stable chronic medical conditions,completed fatigue assessment questionnaires. Patients with low vitamin D levels received ergocalciferol therapy for 5 weeks. Scores of pre- and post-treatment fatigue assessment questionnaires were compared.
RESULTS:
Prevalence of low vitamin D was 77.2% in patients who presented with fatigue. After normalization of vitamin D levels fatigue symptom scores improved significantly (P < 0.001) in all five subscale categories of fatigue assessment questionnaires.
CONCLUSION:
The prevalence of low vitamin D is high in patients who present with fatigue and stable chronic medical conditions, if any. Normalization of vitamin D levels with ergocalciferol therapy significantly improves the severity of their fatigue symptoms.
PMID: 25210673
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