Calcium-vitamin D co-supplementation influences circulating inflammatory biomarkers and adipocytokines in vitamin D insufficient diabetics: a randomized controlled clinical trial
Marjan Tabesh 1,2, Leila Azadbakht 1,2, Elham Faghihimani 3, Maryam Tabesh 1, and Ahmad Esmaillzadeh 1,2
1Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;
2Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran;
3Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Received: April 07, 2014; Accepted: August 05, 2014; Published Online: September 12, 2014
Context:
To the best of our knowledge, no study has examined the effects of vitamin D-calcium co-supplementation on inflammatory biomarkers and adipocytokines in vitamin D insufficient type 2 diabetics.
Objective:
This study was performed to assess the effects of vitamin D and calcium supplementation on inflammatory biomarkers and adipocytokines in vitamin D insufficient people with type 2 diabetes.
Methods:
Totally, 118 diabetic patients were enrolled in this randomized placebo controlled clinical trial. After matching for age, sex, body mass index, type and dose of hypoglycemic agents and duration of diabetes, subjects were randomly assigned into four groups receiving:
- 1) 50000 IU/wk vitamin D + calcium placebo;
- (2) 1000 mg/d calcium+vitamin D placebo;
- 3) 50000 IU/wk vitamin D + 1000 mg/d calcium;
- 4) vitamin D placebo+calcium placebo for 8 weeks.
Blood sampling was done for quantification of inflammatory biomarkers and adipocytokines at study baseline and after 8 weeks of intervention.
Results:
Calcium (changes from baseline: -75±19 ng/ml, P=0.01) and vitamin D alone (-56±19 ng/ml, P=0.01) and joint calcium-vitamin D supplementation (-92±19 ng/ml, P=0.01) resulted in a significant reduction in serum leptin levels compared with placebo (-9±18 ng/ml). This was also the case for serum IL-6; such that calcium (-2±1 pg/ml, P<0.001) and vitamin D alone (-4±1 pg/ml, P<0.001) and their combination (-4±1 pg/ml, P<0.001) led to significant reductions compared with placebo (3±1 pg/ml). After adjustment for potential confounders, individuals in calcium (-3.1±1.3, P<0.05), vitamin D (-3.1±1.3, P<0.05) and joint Ca-D groups (-3.4±1.3, P<0.05) had greater reductions in serum TNF-α concentrations compared with placebo (0.1±1.2). Individuals who received joint calcium-D supplements tended to have a decrease in serum hs-CRP levels compared with placebo after controlling for baseline levels (-1.14±0.25 vs. 0.02±0.24 ng/ml, P=0.09).
Conclusion:
Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-α concentrations in vitamin D insufficient people with type 2 diabetes.
Comment by VitaminDWiki:
Would have been even more successful if they had :
- used a loading dose of vitamin D - say 200,000 to 400,000 IU in the first week
- extended the trial longer
- Had also used Magnesium
See also VitaminDWiki
- Overview Diabetes and vitamin D
- Proof that Vitamin D Works the study on this page adds the 4th proof that Diabetes is treated by Vitamin D
- Diabetes prevention RCT kicked off: adding 4,000 IU vitamin D - Oct 2013
- Type 2 Diabetes helped by Omega-3 and Vitamin D – Feb 2014
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Diabetes (Type II) reduced by single injection of 300,000 IU of vitamin D3 – RCT March 2014
Pages listed in BOTH the categories Diabetes and Magnesium
- Vitamin D Roles - more than just help the immune system
- Retinopathy in males 6.9 X more likely if low vitamin D and low Magnesium - June 2024
- Magnesium Depletion Score predicts increased risk of various health problems
- High fluoride in water: 5X more likely to be Vitamin D deficient – Jan 2023
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Treating pre-diabetes with Magnesium Chloride should be cost effective – June 2022
- Reduced Magnesium is associated with reduced health (Diabetes in this case) - April 2022
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019
- Young Diabetics had 3.8 X higher risk of Parkinson’s (perhaps low Mg or low Vitamin D)– June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Diabetes 29 % less likely if consume lots of Magnesium and cereal fiber (surveys of 200,000 people) – Oct 2017
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Type 2 diabetes associated with low Magnesium
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015
- Type II Diabetes might be prevented and treated with Magnesium – Review Feb 2015
- Diabetes decreased with 300 mg of Mg (Mg Sulfate) – RCT July 2014
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Diabetes and low Magnesium - Mercola 2014 - 2019
- Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013
- Low Magnesium and type II diabetes – June 2012
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Reduced chance of diabetes 46 percent with Magnesium - Oct 2010
Pages listed in BOTH the categories Omega-3 and Inflammation
- Opioid addiction reduced by Omega-3 (gut inflammation in mice) – Aug 2019
- Treat wounds, stop inflammation with nanoemulsion textile of Omega-3 and Resveratrol - Sept 2019
- Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
- Sepsis reduced the Omega-3 response and half life – April 2019
- Pollutants increase Respiratory problems, Vitamin D, Omega-3, etc. decrease them – May 2018
- Severe acute pancreatitis treated in 11 ways by Omega-3 in just 7 days – RCT April 2018
- Omega-3 treats animal inflammation better than human (those studies use higher doses and different ratios than for humans) - March 2018
- Omega-3 helps muscles and reduces inflammation, lipids, and insulin – Nov 2015
- Omega-3 improves gut bacteria, reduces inflammation and depression – Dec 2017
- Can burn pain be relieved by 4 g of Omega-3 and 2,000 IU of vitamin D – RCT due 2021
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Omega-3 reduces many psychiatric disorders – 2 reviews 2016
- Depression due to inflammation reduced by Omega-3 (children and pregnant) – Nov 2015
- Omega-7 - in addition to Omega-3
- Inflammation reduction through diet: Omega-3 etc. Feb 2014
- Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013
- Omega-3 reduced vitamin D3 inflammation for obese – RCT Jan 2013
See blog post of the study at Vitamin D Council
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