Vitamin D Deficiency at 16-20 Weeks Gestation Is Associated with Impaired Lung Function and Asthma at 6 Years of Age.
Ann Am Thorac Soc. 2014 Mar 6.
Zosky GR 1, Hart PH, Whitehouse AJ, Kusel MM, Ang W, Foong RE, Chen L, Holt PG, Sly PD, Hall GL.
1University of Tasmania, School of Medicine, Hobart, Tasmania, Australia, University of Western Australia, Telethon Institute for Child Health Research, Subiaco, Australia ; Graeme.Zosky at utas.edu.au.
Rationale: Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal vitamin D deficiency during the early stages of lung development and post-natal lung function in human populations.
Objectives: To assess the association between maternal vitamin D deficiency, post-natal lung function and asthmatic status in a longitudinal birth cohort.
Methods: Serum was collected at 16-20 weeks gestation at the time of recruitment in a community based prospective birth cohort for measurement of vitamin D (25(OH)D). Lung function was assessed by spirometry according to ATS guidelines in children at 6 and 14 years of age. Demographic and clinical history data were collected by questionnaire at recruitment and at the follow up visits.
Measurements and Main Results: FVC Z-scores in both sexes (β; 0.007[0.001, 0.013], p = 0.02) and FEV1 Z-scores in females (β; 0.007[0.001, 0.013], p = 0.02) were positively associated with maternal serum 25(OH)D at 6 years of age. These associations were mostly absent at 14 years of age. Maternal vitamin D deficiency was positively associated with asthma at 6 years of age but only in males (OR; 3.03(1.02-9.02), p = 0.04).
Conclusions: This study supports the notion that vitamin D deficiency during lung development may impact on post-natal lung growth and increase the risk of developing lung disease.
PMID: 24601713
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Pages listed in BOTH of the categories BREATHING and PREGNANCY
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- Small vitamin D doses given during pregnancy do not reduce childhood asthma – meta-analysis Dec 2020
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- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
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- Smoking while pregnant lowers vitamin D and increases child asthma by 3.6 X – Aug 2011
- 800 IU Vitamin D while pregnant decrease child asthma by 2X- Sept 2010
- Vitamin D Newsletter May 2010
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Pages listed in BOTH of the categories BREATHING and INFANT/CHILD
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- 3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023
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- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
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- Both parents smoke – child’s vitamin D level was 30 percent lower and worse asthma – May 2018
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- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
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- Preemies with poor lungs (Respiratory distress syndrome) have low levels of vitamin D – Nov 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Respiratory infection in infant was 7 X more likely if low cord Vitamin D – March 2017