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2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013

Calcium intake and prostate cancer among African Americans: effect modification by vitamin D receptor calcium absorption genotype.

J Bone Miner Res. 2012 Jan;27(1):187-94. doi: 10.1002/jbmr.505.
Rowland GW, Schwartz GG, John EM, Ingles SA.
Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.

High dietary intake of calcium has been classified as a probable cause of prostate cancer, although the mechanism underlying the association between dietary calcium and prostate cancer risk is unclear. The vitamin D receptor (VDR) is a key regulator of calcium absorption. In the small intestine, VDR expression is regulated by the CDX-2 transcription factor, which binds a polymorphic site in the VDR gene promoter. We examined VDR Cdx2 genotype and calcium intake, assessed by a food frequency questionnaire, in 533 African-American prostate cancer cases (256 with advanced stage at diagnosis, 277 with localized stage) and 250 African-American controls who participated in the California Collaborative Prostate Cancer Study. We examined the effects of genotype, calcium intake, and diet-gene interactions by conditional logistic regression. Compared with men in the lowest quartile of calcium intake, men in the highest quartile had an approximately twofold increased risk of localized and advanced prostate cancer (odds ratio [OR] = 2.20, 95% confidence interval [CI] = 1.40, 3.46), with a significant dose-response. Poor absorbers of calcium (VDR Cdx2 GG genotype) had a significantly lower risk of advanced prostate cancer (OR = 0.41, 95% CI = 0.19, 0.90). The gene-calcium interaction was statistically significant (p = 0.03). Among men with calcium intake below the median (680 mg/day), carriers of the G allele had an approximately 50% decreased risk compared with men with the AA genotype. These findings suggest a link between prostate cancer risk and high intestinal absorption of calcium.

Copyright © 2012 American Society for Bone and Mineral Research.

PMID: 21887707

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2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013

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- High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016 Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013 600 mg of Calcium and a gene increases probability of Prostate Cancer by 50 pcnt – Nov 2012 Aggressive Prostate Cancer increased by Calcium but decreased by Vitamin D (genes too) – Nov 2014 Poorly functioning Vitamin D Receptor (VDR) was 5X more likely in children with low vitamin D levels – July 2012 Prostate Cancer – 300,000 annual deaths, low vitamin D is one of many factors – current status March 2015 Prostate Cancer associated with CaSR gene – Nov 2012

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