Vitamin D papers (28 free PDFs) in Journal of Steroid Biochemistry – Jan 2018

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Highlights from the 5th International Conference on Vitamin D Deficiency, Nutrition and Human Health, Abu Dhabi, United Arab Emirates, March 24–25, 2016

Pages 1-3
Afrozul Haq, Sunil J. Wimalawansa, Carsten Carlberg

Clinical practice guidelines for vitamin D in the United Arab Emirates

Pages 4-11
Afrozul Haq, Sunil J. Wimalawansa, Pawel Pludowski, Fatme Al Anouti

The concept of the personal vitamin D response index

Pages 12-17
Carsten Carlberg, Afrozul Haq
Highlights

• The personal vitamin D response index describes the efficiency of the molecular response to supplementation with vitamin D.
• Individuals can be distinguished into high, mid and low responders to vitamin D.
• Vitamin D supplementation doses should be based on the vitamin D status in relation to the personal vitamin D response index.

Multiple unexplained fractures in infants and child physical abuse (in VitaminDWiki)

Pages 18-22 see VitaminDWiki Low Vitamin D in infants - video interview of Dr. Holick - May 2017
John Jacob Cannell, Michael F Holick
Highlights

• Infants with multiple fractures may have rickets instead of being abused.
• Radiologists miss biopsy proven rickets 80% of the time.
• Common sense issues must be considered in child abuse, not just x-rays.
• Infantile rickets may be very common, to date no one has studied its prevalence.
• It is possible that an ultrasound study of newborns will be very informative.

Vitamin D deficiency and the pathogenesis of Crohn’s disease

Pages 23-28
John H. White
Highlights

• Crohn’s disease (CD) arises from defective intestinal innate immunity.
• Vitamin D has emerged as a major regulator of human innate immunity.
• Emerging evidence suggests that vitamin D deficiency contributes to CD pathogenesis.
• Vitamin D supplementation may be of benefit in clinical management of CD.

Vitamin D and cardiovascular diseases: Causality

Pages 29-43
Sunil J. Wimalawansa

Sunlight exposure: Do health benefits outweigh harm?

Pages 44-48
Mohammed S. Razzaque
Highlights

• About 80% of required vitamin D in human is generated by UVB sunlight.
• UVB exposure can decrease blood pressure, possibly by increasing 1,25(OH)2D levels.
• UVB exposure has numerous beneficial effects other than vitamin D production.
• Expected benefits of vitamin D supplements are reduced by potential risk of toxicity.
• Supplement-induced vitamin D toxicity may be mediated by increase phosphate burden.

Vitamin D status among the juvenile population: A retrospective study (in VitaminDWiki)

Pages 49-54  ~ see VitaminDWiki Vitamin D levels in juveniles in UAE decrease with age – Jan 2017
Afrozul Haq, Jitka Svobodová, Nighat Y. Sofi, Andrea Jindrová, Bohumil Kába, Jaishen Rajah, Fatme Al Anouti, Laila Abdel-Wareth, Sunil J. Wimalawansa, Mohammed S. Razzaque

Nutritional risk factors and status of serum 25(OH)D levels in patients with breast cancer: A case control study in India

Pages 55-59
Nighat Y. Sofi, Monika Jain, Umesh Kapil, Vuthaluru Seenu, Vineet Kumar Kamal, Ravinder Mohan Pandey
Highlights

• Nutritional risk factors in breast cancer among women in India.
• Few nutritional risk like frequency of consumption for mushrooms and fruits and type of fat was found to be associated with the risk of breast cancer.
• India has no guidelines for defining vitamin D deficiency. The cutoffs used were adopted from US Endocrine society.
• A significant association with breast cancer was observed after comparing serum levels of 25(OH)D of <20 ng/ml with ≥20 ng/ml.

Non-musculoskeletal benefits of vitamin D (in VitaminDWiki)

Pages 60-81 In VitaminDWiki
Sunil J. Wimalawansa

Role of vitamin D on gut microbiota in cystic fibrosis

Pages 82-87
Mansi Kanhere, Benoit Chassaing, Andrew T. Gewirtz, Vin Tangpricha
Highlights

• Vitamin D plays a vital role in maintaining the integrity of the gut epithelium.
• The mechanism underlying this association involves the reduction of pro-inflammatory cytokines such as IL-8 and inhibition of inflammation-induced apoptosis of intestinal epithelial cells by vitamin D.
• Intestinal dysbiosis is prevalent in CF owing to multiple factors including malabsorption of nutrients and recurrent antibiotics.
• VDR regulates the composition and functions of the gut microbiota and decreased expression of intestinal epithelial VDR disrupts microbial homeostasis.
• Vitamin D could be a potential treatment option for altering dysbiosis in CF, but additional trials are needed to evaluate this.

See also VitaminDWiki Cystic Fibrosis

Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK

Pages 88-96
David A. Jolliffe, Kate Kilpin, Beverley D. MacLaughlin, Claire L. Greiller, Richard L. Hooper, Neil C. Barnes, Peter M. Timms, Raj K. Rajakulasingam, Angshu Bhowmik, Aklak B. Choudhury, David E. Simcock, Elina Hyppönen, Christopher J. Corrigan, Robert T. Walton, Christopher J. Griffiths, Adrian R. Martineau
Highlights

• Vitamin D deficiency is common among UK adults with ICS-treated asthma.
• Classical environmental determinants of vitamin D status operate in this population.
• Vitamin D status did not associate with markers of asthma severity or control.
• Genetic variation in the vitamin D pathway did not influence vitamin D status or measures of asthma severity or control.

Serum 25-hydroxyvitamin D levels in a healthy population from the North of Portugal

Pages 97-101
Andreia Bettencourt, Daniela Boleixa, Júlia Reis, José Carlos Oliveira, Denisa Mendonça, Paulo Pinho Costa, Berta Martins da Silva, António Marinho, Ana Martins da Silva
Highlights

• This is the first report of 25-hydroxyvitamin D levels in a healthy adult Portuguese population.
• A high prevalence of vitamin D deficiency and insufficiency was observed, regardless gender.
• Serum 25-hydroxyvitamin D levels were inversely correlated with body mass index.
• An effective strategy to prevent vitamin D deficiency and insufficiency should be implemented.

Vitamin D in Saudi Arabia: Prevalence,distribution and disease associations

Pages 102-107
Nasser M. Al-Daghri
Highlights

• The over-all prevalence of vitamin D deficiency (<50 nmol/l) in Saudi Arabia from 2011 to 2016 is 81.0% (Confidence Interval 95% 68.0–90.0).
• Most local studies have been observational and therefore diseases linked to vitamin D deficiency in KSA lacks causality.
• Local guidelines for the identification and treatment of candidates at risk for vitamin D deficiency complications is warranted.

Developmental vitamin D deficiency and autism: Putative pathogenic mechanisms

Pages 108-118
Asad Ali, Xiaoying Cui, Darryl Eyles

Highlights

• Developmental Vitamin D deficiency during early periods of brain development is linked to Autism.
• Developmental Vitamin D deficiency alters response to inflammation.
• Vitamin D deficiency alters steroidogenesis.
• Developmental Vitamin D deficiency alters foetal brain anatomy.
• Developmental Vitamin D deficiency produces behavioural phenotypes relevant to autism.

Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus

Pages 119-124
Habiba Al Safar, Sarah El Hajj Chehadeh, Laila Abdel-Wareth, Afrozul Haq, Herbert F. Jelinek, Gehad ElGhazali, Fatme Al Anouti
Highlights

• The UAE has one of the highest rates of Type 2 Diabetes Mellitus (T2DM) in the world.
• In this study, 264 patients with T2DM and 91 healthy controls were enrolled.
• Vitamin D receptor (VDR) gene is a good candidate for T2DM susceptibility among Emiratis.
• Alleles and haplotypes of the VDR gene are associated with susceptibility to T2DM in Emiratis.
• G-allele and GG genotype of rs2228570 and T-allele and TT genotype of rs1544410 SNPs were associated with T2DM.

Vitamin D supplementation guidelines (in VitaminDWiki)

Pages 125-135 in VitaminDWiki Vitamin D supplementation guidelines (adults – 50,000 IU per week) – Feb 2017
Pawel Pludowski, Michael F. Holick, William B. Grant, Jerzy Konstantynowicz, Mario R. Mascarenhas, Afrozul Haq, Vladyslav Povoroznyuk, Nataliya Balatska, Ana Paula Barbosa, Tatiana Karonova, Ema Rudenka, Waldemar Misiorowski, Irina Zakharova, Alena Rudenka, Jacek Łukaszkiewicz, Ewa Marcinowska-Suchowierska, Natalia Łaszcz, Pawel Abramowicz, Harjit P. Bhattoa, Sunil J. Wimalawansa
Highlights

• Vitamin D supplementation is crucial for both classic and pleiotropic effects.
• 25(OH)D concentrations of 30–50 ng/mL (75–125 nmol/L) are beneficial for overall health.
• Regional or nationwide vitamin D guidelines are more applicable for general population.
• Disease-specific vitamin D guidelines are applicable globally.
• Vitamin D therapeutic guidelines are applicable globally.

Vitamin D assays in clinical laboratory: Past, present and future challenges

Pages 136-137
Shereen H. Atef
Highlights

• The future of analytical measurement of vitamin D will depend on separation steps.
• Effort to Standardization vitamin D assay.
• Guidelines for testing of Vitamin D stated that no practical reason for most people to get a vitamin D test.

Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK

Pages 138-145 See also VitaminDWiki COPD fought by Vitamin D - many studies
David A. Jolliffe, Wai Yee James, Richard L. Hooper, Neil C. Barnes, Claire L. Greiller, Kamrul Islam, Angshu Bhowmik, Peter M. Timms, Raj K. Rajakulasingam, Aklak B. Choudhury, David E. Simcock, Elina Hyppönen, Robert T. Walton, Christopher J. Corrigan, Christopher J. Griffiths, Adrian R. Martineau
Highlights

• Vitamin D deficiency is common among UK adults with chronic obstructive pulmonary disease.
• Classical environmental determinants of vitamin D status operate in this population.
• Vitamin D status associated with clinical markers of lung function.
• Genetic variation in the vitamin D pathway did not influence vitamin D status or measures of COPD severity.

Maternal early pregnancy vitamin D status in relation to low birth weight and small-for-gestational-age offspring

Pages 146-150
Huiping Wang, Yanfeng Xiao, Lan Zhang, Qiong Gao
Highlights

• Maternal vitamin D deficiency may be an independent risk factor for fetal growth.
• Nonlinear relation between 25(OH)D and birth weight, head circumference were found.
• For each 1 ng/ml decrease of 25(OH)D, the unadjusted and adjusted risk of SGA increased by 19% and 9%.
• Maternal vitamin D insufficiency is associated with low birth weight and high risk of SGA.

Cognitive changes under memantine according to vitamin D status in Alzheimer patients: An exposed/unexposed cohort pilot study

Pages 151-156
Pauline Lemire, Antoine Brangier, Melinda Beaudenon, Guillaume T. Duval, Cedric Annweiler
Highlights

• The onset of hypovitaminosis D was accompanied by cognitive decline.
• Memantine was protective against hypovitaminosis D-related cognitive decline.
• This prompts to give to Alzheimer patients memantine together with vitamin D.

Effects of Vitamin D3 on asymmetric- and symmetric dimethylarginine in arterial hypertension

Pages 157-163
M.R. Grübler, M. Gaksch, K. Kienreich, N.D. Verheyen, J. Schmid, C. Müllner, G. Richtig, H. Scharnagl, C. Trummer, V. Schwetz, A. Meinitzer, B. Pieske, W. März, A. Tomaschitz, S. Pilz
Highlights

• Vitamin D is suggested to be a protective factor for CV-diseases. The potential mechanism might be based on endothelial function.
• We conducted a double-blind randomized controlled trial.
• We supplemented either 2800 IU vitamin d3/day for 8 weeks or placebo.
• We included 200 patients with hypertension and vitamin D insufficiency.
• There was no sign. effect of vitamin d3 on ADMA/SDMA concentrations.
• There was a sign. increase of the arginine/ADMA ratio in patients 25(OH)D concentrations ≤20 ng/mL.

Vitamin D deficiency is associated with an oxidized plasma cysteine redox potential in critically Ill children

Pages 164-169
Jessica A. Alvarez, Jocelyn R. Grunwell, Scott E. Gillespie, Vin Tangpricha, Kiran B. Hebbar
Highlights

• We examined the link between vitamin D, oxidative stress, and immunity in the PICU.
• Vitamin D deficiency was associated with a more oxidized plasma cysteine redox.
• Plasma glutathione was higher in vitamin D deficient subjects.
• The role of vitamin D in regulating plasma redox in the PICU needs further study.

Serum 25(OH)D and adipokines levels in people with abdominal obesity

Pages 170-176
T. Karonova, O. Belyaeva, E.B. Jude, A. Tsiberkin, A. Andreeva, E. Grineva, P. Pludowski
Highlights

• High prevalence of vitamin D deficiency and insufficiency was observed in the study population regardless of gender.
• Obese subjects had lower serum 25-hydroxyvitamin D and adiponectin levels but high leptin level compared to subjects with normal body mass index.
• Serum 25-hydroxyvitamin D (25(OH)D) inversely correlated with weight, waist circumference and body mass index in females but not in males.
• Correlation between leptin and serum 25(OH)D level was found in female but not in male cohorts suggesting a potential gender difference.
• Further studies are needed to understand the interaction between 25(OH)D and serum adipokines in health and under disease-imposed burden.

Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome (in VitaminDWiki)

Pages 177-189
Sunil J. Wimalawansa in ViitaminDWiki Reasons to suspect Diabetes is related to low vitamin D – Jan 2018

Effects of vitamin D status on oral health

Pages 190-194
Anne Marie Uwitonze, Julienne Murererehe, Marie Claire Ineza, Eliane Ingabire Harelimana, Usiel Nsabimana, Peace Uwambaye, Agnes Gatarayiha, Afrozul Haq, Mohammed S. Razzaque

Vitamin D deficiency in mothers, neonates and children

Pages 195-199
Deena H. Elsori, Majeda S. Hammoud

Reproductive factors, nutritional status and serum 25(OH)D levels in women with breast cancer: A case control study

Pages 200-204
Nighat Y. Sofi, Monika Jain, Umesh Kapil, Vuthaluru Seenu, Lakshmy R., Chander P. Yadav, Ravindra M. Pandey, Neha Sareen
Highlights

• Reproductive risk factors contribute to increasing risk of breast cancer in Indian women.
• Sedentary life style and high fat intake together are associated with higher risk of breast cancer demanding healthy changes in dietary preferences and lifestyle modification.
• Vitamin D deficiency continues to affect more than 80% of women diagnosed with breast cancer.
• Reaching a consensus for defining optimal dosage of vitamin D and emphasizing vitamin D intake to avoid breast cancer related morbidity and mortality should be advocated.