Vitamin D: Link between Osteoporosis, Obesity, and Diabetes?
Int. J. Mol. Sci. 2014, 15(4), 6569-6591; doi:10.3390/ijms15046569 (doi registration under processing)
Flávia Galvão Cândido flaviagcandido at hotmail.com and Josefina Bressan
Laboratory of Body Composition and Energy Metabolism, Departamento de Nutrição e Saúde-CCB II, Universidade Federal de Viçosa, Avenida PH Rolfs, s/n, Viçosa, MG 36570-900, Brazil
(This article belongs to the Section Bioactives and Nutraceuticals)
Vitamin D (1,25(OH)2D3) is a steroid hormone that has a range of physiological functions in skeletal and nonskeletal tissues, and can contribute to prevent and/or treat osteoporosis, obesity, and Type 2 diabetes mellitus (T2DM). In bone metabolism, vitamin D increases the plasma levels of calcium and phosphorus, regulates osteoblast and osteoclast the activity, and combats PTH hypersecretion, promoting bone formation and preventing/treating osteoporosis. This evidence is supported by most clinical studies, especially those that have included calcium and assessed the effects of vitamin D doses (≥800 IU/day) on bone mineral density. However, annual megadoses should be avoided as they impair bone health.
Recent findings suggest that low serum vitamin D is the consequence (not the cause) of obesity and the results from randomized double-blind clinical trials are still scarce and inconclusive to establish the relationship between vitamin D, obesity, and T2DM.
Nevertheless, there is evidence that vitamin D
- inhibits fat accumulation,
- increases insulin synthesis and
- preserves pancreatic islet cells,
- decreases insulin resistance and
- reduces hunger, favoring obesity and T2DM control.
To date, there is not enough scientific evidence to support the use of vitamin D as a pathway to prevent and/or treat obesity and T2DM.
Figure 2
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See also VitaminDWiki
- Overview Osteoporosis and vitamin D
- Overview Diabetes and vitamin D
- 20X increase in vitamin D sold and 36 percent decrease in osteoporosis business in Australia – Nov 2013
The Osteo doctors did not tell the patients, they found out for themselves
Do not expect a doctor to recommend a pill which will eliminate his job (vitamin D) - Diseases that may be related via low vitamin D has the following chart
Pages listed in BOTH Obesity AND Diabetes
- Water-soluble form of vitamins are needed for some health problems
- Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
- UV reduces cardiovascular and metabolic problems– Vitamin D plus Nitric oxide – Sept 2023
- Vitamin D both reduces CVD directly and reduces metabolic problems that cause CVD – May 2023
- Non-alcoholic fatty liver disease: 75 percent of overweight adults and type II diabetics – Aug 2022
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Vitamin D might a risk factor of insulin resistance, diabetes, obesity, etc. (50 ng) – Oct 2021
- COVID-19 hospitalizations: 63% associated with diabetes, obesity, hypertension or heart failure – Feb 2021
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- 90 percent remission of recently diagnosed diabetes with a low-calorie diet
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Type II Diabetes is not prevented by a small amount of vitamin D (proven again) – May 2017
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Autistic child 3X more likely if mother was obese and diabetic (both associated with low vitamin D) - Feb 2015
- Diabetes is more likely if low vitamin D than if obese - Feb 2016
- Off Topic: Diabetes 11X increase for just 150 calories of sugar - June 2015
- Obese diabetics with dark skins not benefit from 6,000 IU of vitamin D daily (no surprise) – RCT March 2015
- Vitamin D3 is stored in fat has not been processed by liver – March 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
- Higher vitamin D at birth associated with less diabetes and obesity 35 years later – Jan 2014
- Hypothesis: Obesity causes vitamin D deficiency and type 2 diabetes - 2012
- Insulin sensitivity in obese adolescents greatly improved with 4000 IU of vitamin D - RCT April 2013
- Metabolic Syndrome 10% less likely for every 4 ng increase in Vitamin D – Jan 2013
- No association between diabetes level and vitamin D insufficiency in obese youth – Jan 2013
- African-Americans at high risk of obesity and diabetes - 2011
- Diabetes 6X more likely for those abdominal obese who have insufficient vitamin D – June 2012
- Low vitamin D associated with obesity-related diseases for ethnic minorities – Sept 2011
- Obesity lowers vitamin D which increases probability of diabetes in children – Nov 2011
- Obesity and diabetes reduced when move to better neighborhood – or better UV – Oct 2011
- Vitamin D Levels at Birth May Predict Obesity Risk at age 3 - Oct 2010
- Overview Metabolic Syndrome and vitamin D
- More obese had less vitamin D, and after low calorie diet, vitamin D went up – June 2010
- Vitamin D and Obesity from vitamin D council newsletter of Nov 2006
Pages listed in BOTH Meatabolic Syndrome AND Diabetes
- Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
- UV reduces cardiovascular and metabolic problems– Vitamin D plus Nitric oxide – Sept 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- How Vitamin D prevents Insulin Resistance – Sept 2020
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Cardiometabolic risk reduced by Omega-3 - dissertation Sept 2017
- Upsurge in Metabolic diseases may be due to low vitamin D – May 2016
- Psoriasis is associated with kidney disease, heart problems, diabetes, etc – Nov 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
- Cardiometabolic markers indicate that 11-14 ng is enough vitamin D – Nov 2013
- Metabolic Syndrome 10% less likely for every 4 ng increase in Vitamin D – Jan 2013
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Overview Metabolic Syndrome and vitamin D
Pages listed in BOTH Osteoporosis AND Diabetes
- Magnesium Depletion Score predicts increased risk of various health problems
- Off Topic: Xylitol reduces cavities, preterm births, osteoporosis, RTI, obesity, diabetes, etc. - several studies
- Low bone mineral density is inversely associated with both Vitamin D and Resistin (resistance to insulin)
- Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
- Possible link between osteoporosis and diabetes – July 2010
See also web
- nternational Osteoporosis Foundation (IOF) Bone and Diabetes Scientific Working Group Dec 2015
6 X increased risk of broken bones in patients with type 1 diabetes
Their study only mentions use of 1,000 IU of vitamin D - which is far too little to make a difference
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