Impact of 3-monthly vitamin D supplementation plus exercise on survival after surgery for osteoporotic hip fracture in adult patients over 50 years: A pragmatic randomized, partially blinded, controlled trial
The journal of nutrition, health & aging, pp 1-8, First online: 08 July 2016
Ana Laiz , J. Malouf, A. Marin, V. Longobardi, J. de Caso, J. Farrerons, J. Casademont
88 osteoporotic hip fracture patients
Deaths
| 3-monthly oral doses of 3 mg calcifediol + exercise | Placebo | |
| 1 year | 1% | 10% |
| 4 year | 3.4% | 19.3% |
Note: Calcifediol = calcidiol = 25-hydroxycholecalciferol = 25-hydroxyvitamin D = 25(OH)D)
Wonder why they used Calcifediol. Vitamin D works as well if liver is OK and is far less expensive
Wonder why they used 3 monthly dosing. every 20 days is far better
See also VitaminDWiki
- 1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017
Same study as on this page - Resistance exercise combined with Vitamin D is great for seniors – meta-analysis July 2017
- Calcium and vitamin D supplements after hip fracture reduced death rate by 25% – Feb 2011
- 68+ pages with hip tracture in title as of Dec 2022
- 20 percent fewer male hip fractures if more Magnesium in the water – July 2013
Magnesium is needed to keep bone strength - Surgical outcomes are better for higher levels of Vitamin D – systematic review May 2015
Many surgery outcomes are better with higher levels of vitamin D - Overview Fractures and vitamin D
Objective: To determine whether 3-monthly supplementation of an oral vitamin D widely used in Spain (calcifediol) plus daily exercise could influence survival at one and four years after surgery for osteoporotic hip fracture.
Design
A pragmatic, randomized, partially single-blind placebo-controlled study.
Setting
Patients admitted to a tertiary university hospital for acute hip fracture.
Participants
675 healthy adult patients undergoing surgery for osteoporotic hip fracture were recruited from January 2004 to December 2007.
Intervention
Patients were randomized to receive either 3-monthly oral doses of 3 mg calcifediol (Hidroferol Choque®) or placebo in the 12 months postsurgery. Patients who received calcifediol were also given an exercise programme. The placebo group received standard health recommendations only. Measurements: The primary endpoint was survival at 1 year and at 4 year follow-up. We also recorded new fractures, medical complications and anti-osteoporotic treatment compliance.
Results
We included a total of 88 patients, aged 62 to 99 years. Mean age was 82 years and 88.6% were women. At 12 months, 10 (11.3%) patients had died, 9 of them, from the non-intervention group. At 4 years after surgery, 20 (22.7%) had died, 3 (3.4%) from the intervention group and 17 (19.3%) from the non-intervention group. At this time, survival curve analysis showed 93% survival in the intervention group and 62% in the non-intervention group (p=0.001). At 12-month follow up, there were 18 new fractures, 9 in each group. The non-intervention group had more medical complications, with significant differences at visit 2 (p = 0.04) and 3 (p = 0.02) but not at visit 4 (p = 0.18). No significant differences between groups were found regarding treatment compliance.
Conclusion
3-monthly, oral supplements of 3 mg calcifediol plus daily exercise improved survival at one-year and four-year follow up after surgery for an osteoporotic hip fracture.