Review: The role of vitamin D in nervous system health and disease
Neuropathology and Applied Neurobiology. Volume 39, Issue 5, pages 458–484, August 2013
G. C. DeLuca 1,gabriele.deluca@ndcn.ox.ac.uk
S. M. Kimball 3,
J. Kolasinski 1,
S. V. Ramagopalan 2,
G. C. Ebers 1
1 Nuffield Department of Clinical Neurosciences (Clinical Neurology), University of Oxford, Oxford
2 Blizard Institute of Cell and Molecular Science, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, London, UK
3 Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Vitamin D and its metabolites have pleomorphic roles in both nervous system health and disease. Animal models have been paramount in contributing to our knowledge and understanding of the consequences of vitamin D deficiency on brain development and its implications for adult psychiatric and neurological diseases. The conflation of in vitro, ex vivo, and animal model data provide compelling evidence that vitamin D has a crucial role in proliferation, differentiation, neurotrophism, neuroprotection, neurotransmission, and neuroplasticity. Vitamin D exerts its biological function not only by influencing cellular processes directly, but also by influencing gene expression through vitamin D response elements. This review highlights the epidemiological, neuropathological, experimental and molecular genetic evidence implicating vitamin D as a candidate in influencing susceptibility to a number of psychiatric and neurological diseases.
The strength of evidence varies for
- schizophrenia,
- autism,
- Parkinson's disease,
- amyotrophic lateral sclerosis,
- Alzheimer's disease, and
- is especially strong for multiple sclerosis.
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See also VitaminDWiki
- Search VitaminDWiki for "amyotrophic lateral sclerosis" OR ALS 119 items as of Dec 2013
- Overview Alzheimer's-Cognition and Vitamin D
- Overview MS and vitamin D
- Overview Schizophrenia and Vitamin D
- ALS fought by vitamin D - many studies
- Amyotrophic lateral sclerosis has 4X faster decline if severely low Vitamin D – Nov 2013
- Overview Autism and vitamin D
- Autism treated by Vitamin D: Dr. Cannell - video June 2013 includes reasons why he believes Autism is related to Vitamin D
- Both have strong inheritance features – Vitamin D about 60%
- Both have gotten substantially worse in last 30 years
- Vitamin D is known to be involved in brain development
- All autistic children are VitD deficient, but not all children who are deficient are autistic: genes are involved
- When giving vitamin D to cure children of rickets “mental dullness” decreases as well
- Children with genes which give them too much (Williams Syndrome) have to reverse of autism – too sociable
- Mothers having lots of fish (and thus more vitamin D) give birth to kids with less autistic symptoms
- Both associated with weak bones
- Both worse around the age of weaning
- Autism is more common in rich families – more likely to apply sun screen and stay indoors
- Autism increases with drugs which lower levels of vitamin D
- Seizures are common with Autism - Vitamin D has been shown to reduce seizures
- Fewer autistic symptoms (such as sleep problems) during summer: when child gets more vitamin D from the sun
- Both worse with latitude
- Both vary with Ultraviolet light
- Both vary with time of year (more birth of autistics in March in Northern hemisphere)
- 2X more urban autism – less UVB in urban environments
- Both worse with pollution
- Both worse with increased clouds and rain
- Both worse with closely spaced pregnancies
- Autistics have abnormal immune response – similar to that of vitamin D deficiency
- Low levels of vitamin D in mother animals reduces brain function in offspring
- Vitamin deficient rat pups have similar brain abnormalities to that of human autistic children
- Autistic children get less vitamin D in their blood for the same amount of sun exposure
- The 4 males/1 female ratio - Note estrogen increases vitamin D in the brain (testosterone does not)
- Both worse in African Americans (A-A 2-3 increased autism rate)
- Both worse in Dark-skinned immigrants in Europe
- Note: All articles in Autism category
165 items Vitamin D and MS, ALS, Autism, Alzheimer’s and other nervous system diseases – review Aug 201318665 visitors, last modified 27 Dec, 2013, This page is in the following categories (# of items in each category)