- The effectiveness of interventions to reduce the transmission of acute respiratory infections in care homes: a systematic review
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The effectiveness of interventions to reduce the transmission of acute respiratory infections in care homes: a systematic review
Journal of Public Health, fdae178, https://doi.org/10.1093/pubmed/fdae178
Merlin L Willcox, Deepthi Lavu, Usaid Yousaf, Sam Dalton, Nia Roberts, Annette Plüddemann
Background
Care home residents are at high risk from outbreaks of respiratory infections, such as influenza and COVID-19. We conducted a systematic review of randomized controlled trials, to determine which interventions (apart from vaccines) are effective at reducing transmission of acute respiratory illnesses (ARIs) in care homes.Methods
We searched CINAHL, Medline, Embase and Cochrane for randomized controlled trials (RCTs) of interventions to prevent transmission of ARIs in care homes (excluding vaccines), to April 2023.Results
A total of 21 articles met inclusion criteria. Two infection control interventions significantly reduced respiratory infections.- Oseltamivir significantly reduced risk of symptomatic laboratory-confirmed influenza (OR 0.39, 95%CI 0.16–0.94, three trials), and influenza-like illness (OR 0.50, 95%CI 0.36–0.69), even in a vaccinated population.
- High dose vitamin D supplementation reduced incidence of ARIs (incidence rate ratio 0.60; 95%CI 0.38–0.94, one trial).
Nine other RCTs of vitamin, mineral, probiotic and herbal supplements showed no significant effect.
Conclusion
Transmission of respiratory infections in care homes can be reduced by educational interventions to improve infection control procedures and compliance by staff, by antiviral prophylaxis soon after a case of influenza has been detected, and by supplementation with high-dose Vitamin D3. Further research is needed to confirm the effect of high-dose Vitamin D3.How this fits in
- NICE guidelines recommending antiviral prophylaxis for care home residents, during influenza outbreaks, are often not implemented. This research shows that antiviral prophylaxis can halve the risk of influenza even in vaccinated care home residents, if given within 7 days of the first case in the care home.
- Current NICE guidelines recommend supplementation with Vitamin D at 400 IU daily. This research shows that high-dose supplementation (100 000 IU per month) can reduce risk of respiratory infections by 40%.
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Refers to: High-dose monthly vitamin D for prevention of acute respiratory infection in older longterm care residents - RCT 2017
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12+ VitaminDWiki Immunity pages have RCT in the title
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Meta-analyses of Virus
44 studies This list is automatically updated
- COVID ICU use reduced by 42% if take more than 100,000 IU of vitamin D over two weeks – meta-analysis Sept 2024
- Vaccinations did not stop COVID (68 studies) – meta-analysis May 2023
- Influenza risk cut in half by the only trial giving enough vitamin D for body weight – meta-analysis Jan 2022
- Multiple Vitamin D doses reduced COVID ICU by 2.5 X , Mech. Ventilation by 5.5 X – meta-analysis May 2024
- COVID death rate in hospital halved if take any amount of vitamin D for any length of time – meta-analysis May 2024
- COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis April 2024
- COVID fought by Vitamin D: 2.3X less likely to die of COVID if supplemented, 1.9 X less likely to become infected – meta-analysis March 2024
- COVID Vaccinations increased risk of cardiac deaths in youths by 19% - Aug 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Yet another reason to take Vitamin D while pregnant – fight COVID - meta-analysis May 2023
- COVID death 1.5 X less likely if high vitamin D, emergency D (50K to 100K) is great – meta-analysis March 2023
- COVID ICU 3X less-likely if take any amount and type of Vitamin D – meta-analysis Jan 2023
- COVID and Vitamin D: any amount of D, at any time, for any duration reduced ICU - meta-analysis Dec 2022
- Worse COVID during 3Q pregnancy if 2.5 ng lower Vitamin D – meta-analysis Sept 2022
- Severe COVID 2.6 X less likely if supplement with Vitamin D – 26th meta-analysis - July 2022
- COVID Long-Haul prevalence increases with time: 50% at 4 months - meta June 2022
- COVID test positive is about half as likely if have Vitamin D – 24th meta-analysis - Jan 2022
- Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis Jan 2022
- Vitamin D fights COVID (54 studies of 1,400,000 people) – 23rd meta-analysis - Dec 2021
- COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis - Dec 29, 2021
- COVID-19 death increased 2X if low Vitamin D (less than 10 to less than 30 ng) – 21st meta-analysis Dec 2021
- COVID-19 risk reduced by vitamin D supplementation – umbrella review of 7 meta-analysis – Oct 2021
- COVID-19 treated by Vitamin D (example: ICU reduced by 5X) – 20th meta-analysis Oct 13, 2021
- Severe COVID-19 2.5 X more likely if low vitamin D (23 studies) – 19th meta-analysis Oct 2021
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- COVID-19 death 1.6 X more likely if low vitamin D (24 studies) – 17th meta-analysis Aug 2021
- Severe COVID-19 5X more likely if low vitamin D (23 studies) – 16th meta-analysis July 2021
- Severe COVID-19 3.5 more likely if low vitamin D (30 studies) – meta-analysis July 2021
- COVID-19 patients who had supplemented with Vitamin D were 3X less likely to enter ICU – June 2021
- Low Calcium associated with severe COVID-19 – several studies
- COVID-19 mortality 3X more likely if low vitamin D (999,179 people) – meta-analysis March 29, 2021
- COVID-19 was 2.6X more severe if very low Vitamin D (43 studies) – meta-analysis March 26, 2021
- Low Vitamin D associated with 2.7X more severe COVID-19 – 12th MA March 5, 2021
- Vitamin D supplementation fights COVID-19 – 11th meta-analysis Jan 24, 2021
- 3.7 X less likely to die of COVID-19 if supplemented with Vitamin D - meta-analysis Jan 5, 2021
- Less likely to test positive for COVID-19 if higher Vitamin D – meta-analysis Jan 6, 2021
- Vitamin D reduces COVID-19 by 80 percent - anonymous meta-analysis - Jan 5, 2021
- COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis Oct 2020
- Low Vitamin D associated 1.8X increased risk of COVID-19 death in hospital – meta-analysis Nov 4, 2020
- Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020
- Prudent to consider that Vitamin D has a role in COVID-19 – meta-analysis – Aug 7, 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hepatitis B patients have 2 ng lower level of Vitamin D – meta-analysis June 2019
- Influenza Vaccination not benefited by lowish levels of vitamin D – meta-analysis March 2018
VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
As of March 31, 2024, the VitaminDWiki COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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VitaminDWiki – Respiratory infection, children and Vitamin D - many studies
VitaminDWiki – Viral respiratory infections reduced by both Vitamin D and Zinc – meta-analysis -Oct 2021
Viral infections reduced 40% by monthly 100,000 IU Vitamin D – RCT review Aug 2024(Cached) Printer Friendly Follow this page for updates1526 visitors, last modified 13 Aug, 2024, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 21575 Ginde 2017.webp admin 13 Aug, 2024 11.29 Kb 55 21574 100K monthly RCT_CompressPdf.pdf admin 13 Aug, 2024 133.68 Kb 18 21573 100,000 IU monthly.webp admin 13 Aug, 2024 11.21 Kb 46 21572 acute respiratory infections D RCT review_CompressPdf.pdf admin 13 Aug, 2024 334.95 Kb 17