VITAMIN D DEFICIENCY AND NEUROLOGIC OUTCOME AFTER SUDDEN CARDIAC ARREST
SHOCK, Vol. 52, No. 6, pp. ei46-ei52, 2019
- Sudden cardiac arrest 6X worse outcome if low vitamin D – Nov 2014
- CPR with low vitamin D – 10X more likely to have poor outcome within 3 months – Jan 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012
- Recurrrent Cardiovascular deaths cut in half if 10 ng more Vitamin D – meta-analysis Sept 2021
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Mortality
Jung-Joon Cha,* and Jin Wi*+
'Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College
of Medicine, Seoul, Korea; and fDivision of Cardiology, Department of Internal Medicine,
Gachon University Gil Medical Center, Incheon, Korea
Background: Vitamin D deficiency is related to various cardiovascular diseases, including sudden cardiac arrest (SCA). This study investigated the association of vitamin D level with neurologic outcome and mortality after resuscitation from SCA.
Patients and Methods: We enrolled patients who were successfully resuscitated from out-ofhospital cardiac arrest of presumed cardiac cause in Severance Cardiovascular Hospital as a prospective cohort registry. Baseline blood samples including pH, lactate, and vitamin D were obtained without fluid replacement just after hospital admission. Outcome was assessed by cerebral performance category (CPC) score at 1 month after SCA. Favorable outcome was defined as survival with CPC score of 1 or 2, whereas unfavorable one as death or survival with CPC scores of 3 through 5. Severe vitamin D deficiency was defined as 25(OH)D <10ng/mL.
Results: A total of 163 patients were included. Overall 96 (59%) patients had a favorable neurologic outcome, whereas 67 patients (41%) showed unfavorable outcome, including 37 (23%) mortality. Patients with unfavorable outcome were likely to be female and have initial non- shockable rhythm, longer arrest time, severe shock, diabetes, and baseline renal dysfunction. In multivariate analysis, severe vitamin D deficiency was one of the poor prognostic factors of both unfavorable neurologic outcome and mortality after SCA.
Conclusions: Vitamin D deficiency is very prevalent and strongly associated with both unfavorable neurologic outcome and mortality in patients resuscitated from SCA.