- VITAMIN D AND STILLBIRTH -OP No. 20
- VitaminDWiki - Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies
- VitaminDWiki - 5 studies in both categories Pregnancy and Fortification
- VitaminDWiki - Pregnancy category contains
- VitaminDWiki – Healthy pregnancies need lots of vitamin D contains
- VitaminDwiki – Fortification with Vitamin D contains
- VitaminDwiki – Change of Vitamin D Fortification in Denmark contains
VITAMIN D AND STILLBIRTH -OP No. 20
Anticancer Research May 2024, 44 (5) 2249-2268; DOI: https://doi.org/10.21873/anticanres.17034
Presented at Proceedings of the Joint International Symposia: Vitamin D in Prevention and Therapy and Biologic Effects of Light May 04-06, 2022 Schlossberg Hotel, Homburg/Saar, Germany
Pelle G. Lindqvist Karolinska Institute, Stockholm, Sweden
Background/Aim: Two retrospective studies of prospective cohorts showed doubled odds of birth asphyxia among women with low plasma vitamin D levels and one reported a 4-fold increase in the odds of stillbirth. It was not known if this was caused by low sun exposure or by vitamin D per se.
Patients and Methods: The stillbirth rate, including all pregnancies in Finland and Sweden between 1994 to 2021 (n>4 million), was analysed. Due to 50% of the population having low plasma vitamin D, Finland implemented an extensive National Vitamin D fortification program in 2003, which was doubled in 2009 due to an insufficient effect. After 2009, only 10% had low vitamin D levels. Stillbirth rates were compared using cross-tabulation with 95% confidence intervals.
Results: Stillbirth rate decreased from 4.1% before 2003 to 3.2% to 2.% after 2009. Meanwhile, the Swedish stillbirth rate remained constant at 3.9% untill 2018 when the Finish fortification was implemented in Sweden. Thereafter, it decreased to 3.2%. All results had p<0.001.
Conclusion: In our large study of National vitamin D fortification, improved vitamin D status was associated with a lower stillbirth rate in a dose-dependent manner.
VitaminDWiki - Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies
VitaminDWiki - 5 studies in both categories Pregnancy and Fortification
This list is automatically updated
- Stillbirth rates dropped from 4.1% to 2.8% as Finland increased Vitamin D fortification – May 2022
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Preeclampsia of offspring cut in half if mother who smoked had vitamin D fortified margarine – Dec 2017
- Schizophrenia increased 40 percent for Spring births after Danes stopped vitamin D fortification – April 2014
- Vitamin D and Folate fortification of foods - April 2012
VitaminDWiki - Pregnancy category contains
924 items in Pregnancy category- see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:Dark Skin 30; Depression 21; Diabetes 44; Obesity 17; Hypertension 44; Breathing 36; Omega-3 44; Vitamin D Receptor 24 Click here for details
- All items in category Infant/Child 854 items
- Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
- 38+ papers with Breastfed etc, in the title
- Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
- 53+ preeclampsia studies
- 94+ studies with PRETERM in the title
- Fertility problem (PCOS) reduced by vitamin D, etc: many studies 15+
- 94+ Gestational Diabetes
- Caesarean birth much more likely if low Vitamin D - many studies 15+ studies
- Post-partum depression and low Vitamin D - many studies 15+ studies
- Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies 5+ studies
- Search VitaminDWiki for "Assisted reproduction" 33 items as of Aug 2022
- Fertility and Sperm category listing has 142 items along with related searches
- (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Less labor pain if higher level of vitamin D – August 2021
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
VitaminDWiki – Healthy pregnancies need lots of vitamin D contains
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
Click on hyperlinks for details
Problem | Vit. D Reduces | Evidence |
0. Chance of not conceiving | 3.4 times | Observe |
1. Miscarriage | 2.5 times | Observe |
2. Pre-eclampsia | 3.6 times | RCT |
3. Gestational Diabetes | 3 times | RCT |
4. Good 2nd trimester sleep quality | 3.5 times | Observe |
5. Premature birth | 2 times | RCT |
6. C-section - unplanned | 1.6 times | Observe |
Stillbirth - OMEGA-3 | 4 times | RCT - Omega-3 |
7. Depression AFTER pregnancy | 1.4 times | RCT |
8. Small for Gestational Age | 1.6 times | meta-analysis |
9. Infant height, weight, head size within normal limits | RCT | |
10. Childhood Wheezing | 1.3 times | RCT |
11. Additional child is Autistic | 4 times | Intervention |
12.Young adult Multiple Sclerosis | 1.9 times | Observe |
13. Preeclampsia in young adult | 3.5 times | RCT |
14. Good motor skills @ age 3 | 1.4 times | Observe |
15. Childhood Mite allergy | 5 times | RCT |
16. Childhood Respiratory Tract visits | 2.5 times | RCT |
RCT = Randomized Controlled Trial
VitaminDwiki – Fortification with Vitamin D contains
135 items in Fortification categoryFortification works, even if food is cooked, but govts rarely fortifiy with enough
Govts, food producers, and families can fortify:
milk, yogurt, beer, bread, cereals, cooking oil, soups, jams, jellys, honey, snack bars, etc.
Some interesting fortification articles
- Biofortification with Vitamin D - several studies
- Vitamin D fortification in Europe preventing 27,000 Cancer deaths, could prevent 129,000 – May 2022
- Vitamin D fortification could eliminate 1 in 10 Cancer deaths in the EU – May 2022
- After years of adding vitamin D, Finland now has 38 ng levels - March 2022
- Fortification with Vitamin D works – 16 studies of Danish experience – July 2021
- Vitamin D fortification of beverages – Review March 2022
- Bread fortified with Vitamin D - many studies 13+ studies
- International Conference of Vitamin D Fortification of Food (India) – Sept 2018
- 2400 IU of vitamin D needed to get most Northern adults above 20 ng – June 2020
- Vitamin D home fortification- don't wait 100 years for your govt
VitaminDwiki – Change of Vitamin D Fortification in Denmark contains
- 60 percent more life births after infertility diagnosis if Vitamin D fortification (Denmark) - Nov 2019
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Vitamin D added to margarine reduced inflammatory bowel disease by 13 percent 30 years later – Nov 2019
- Preeclampsia of offspring cut in half if mother who smoked had vitamin D fortified margarine – Dec 2017
- Danish study of childhood diseases vs vitamin D fortification – May 2013
- 9 studies by Denmak D-Tech group (fortifiy Margarine with Vitamin D) online as of Nov 2019