Some benefits of 5 year VITAL trial (D and Omega-3) observed 2 years later - Jan 2024

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Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes at Two Years after VITAL Trial Completion

Arthritis Rheumatol 2024 Jan 25. doi: 10.1002/art.42811 PDF is behind a paywall
Karen H Costenbader 1 2, Nancy R Cook 2 3 4, I-Min Lee 2 3 4, Jill Hahn 3, Joseph Walter 4, Vadim Bubes 4, Gregory Kotler 4, Nicole Yang 1 2, Sonia Friedman 2 5, Erik K Alexander 2 6, JoAnn E Manson 2 3 4

Objective: In the 5.3 year randomized, 2 x 2 factorial, double-blind, placebo-controlled VITamin D and OmegA-3 TriaL (VITAL), vitamin D supplementation reduced autoimmune disease (AD) incidence (hazard ratio HR 0.78, 95% confidence interval 0.61-0.99). Omega-3(n-3) fatty acid supplementation showed a statistically non-significant reduction (HR 0.85, 0.67-1.08). We aimed to confirm further AD cases arising during and after randomization and assess sustained effects with 2 years of post-intervention observation.

Methods: Of the 12,786 men ≥ age 50 and 13,085 women ≥ age 55 initially randomized, we followed surviving and willing participants for 2 more years. We continued to confirm annual participant-reported new AD by medical record review. Cox models calculated HRs for all confirmed AD, and for secondary endpoints, confirmed and probable cases, and individual ADs, including the observational period and during randomized time.

Results: 21,592 participants (83.5%) were followed observationally for two more years. 514 participants had incident confirmed AD (236 since prior report). 255 had been randomized to vitamin D vs. 259 to vitamin D placebo: HR 0.98 (0.83-1.17) at 7 years. AD was confirmed in 234 participants initially randomized to n-3 fatty acids vs. 280 randomized to its placebo: HR 0.83 (0.70-0.99) at 7 years. Of newly confirmed cases, 65 had onset during randomization; their inclusion changed randomized results to: HR 0.85 (0.70-1.04) for vitamin D and HR 0.87 (0.71-1.06) for n-3 fatty acids.

Conclusions: Two years after trial termination, vitamin D 2000 IU/day's protective effects dissipated, but 1000 mg/day n-3 fatty acids had a sustained effect in reducing AD incidence.

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Reasonable - Many health problems take years to develop.

The final 4 years of the trial prevented many health problems from starting
It is conceivable that the benefits will be seen for 5 to 10 years.

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VitaminDWiki - 4 studies in both categories Autoimmune and Omega-3

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VitaminDWiki – Autoimmune category contains

• 204 items in Autoimmune category
• Vitamin D and   MS    Asthma    RA    Diabetes    Gut   Allergy    Hay Fever    Lupus    Psoriasis
• Predicted 95% autoimmune cured by HIGH-DOSE vitamin D - 2014
• 10% of the UK have Autoimmune Diseases - Lancet May 2023 PDF is behind a paywall
  • Increase in 20 years : coeliac disease 2.19 X. Sjogren's syndrome 2.09, and Graves' disease 2.07
  • All 43 references are FREE on-line
• Autoimmune diseases fought by Vitamin D, especially if have more than 40 ng – Sept 2022
• The BEST Nutrient for Autoimmune Conditions (Vitamin D) - video May 2022
• The number 1 Deficiency behind All Autoimmune Diseases (Vitamin D) video - Dec 2023
• Autoimmune disease clusters run in families having low D
• How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
• 120 doctors and 20,000 MS patients using high dose Vitamin D Dec 2018
• Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
• Vitamin D Receptor is associated in over 58 autoimmune studies
• More autoimmune disease if higher pollution or lower UVB - Feb 2023
• Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
  

See also web: consensus that ~50 diseases are autoimmune, ~50 more are suspected:

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VitaminDWiki – Vitamin D Receptor is associated in over 58 autoimmune studies

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8+ VitaminDWiki pages concern the VITAL trial

This list is automatically updated