Association of vitamin D receptor gene FokI and TaqI polymorphisms and risk of RDS.
J Matern Fetal Neonatal Med. 2019 Feb 13:1-201. doi: 10.1080/14767058.2019.1582629.
Ustun N1, Eyerci N2, Karadag N1, Yesilyurt A2, Zenciroglu A1, Okumus N1.
1 Neonatology Dr Sami Ulus Maternity and Children's Training and Research Hospital , Ankara , Turkey.
2 Dept of Genetics , Dıskapı Yıldırım Beyatız Education and Training Hospital , Ankara , Turkey.
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D Receptor |
| 13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
| 14) Butyrate especially gut | Vitamin D Receptor |
| 15) Berberine | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Items in both categories VDR and Infants are listed here:
- Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
- Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023
- COVID kids were more likely to have a poor VDR (4.3 X), than low Vitamin D (2.6 X) – Sept 2022
- Autism may be synergistically treated by Vitamin D and probiotics – July 2022
- Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022
- Poor hip joint in infants associated with poor Vitamin D receptor – Jan 2021
- Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020
- Autism 2X to 3X more likely if poor Vitamin D Receptor – June 2020
- Infant and child immunity depends on Vitamin D and two Vitamin D genes – Review April 2020
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018
- Juvenile idiopathic arthritis 2.2 X more likely if poor Vitamin D Receptor – Aug 2018
- Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018
- Sudden kidney infection in children was 9X more likely if poor Vitamin D receptor – July 2018
- Sepsis in infants 4.8 X more likely if poor vitamin D receptor – March 2018
- Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- Lupus in children 2.6 X more likely if they had poor Vitamin D Receptor – Jan 2017
- Early tooth decay 1.9 X more likely if a poor Vitamin D receptor – July 2017
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
Items in both categories VDR and Breathing are listed here:
- Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023
- 2X increase risk of Asthma if a particular Vitamin D Receptor mutation – meta-analysis Feb 2022
- Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021
- Mucosal membranes (mouth, lungs, nose, intestines, etc) can activate Vitamin D – July 2020
- Respiratory problems in Children 1.4X more likely if poor Vitamin D receptor – April 2020
- Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019
- Microbiomes of both gut and airway are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019
- Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Best supplements for hay fever (Quercetin, which activates the Vitamin D receptor) - June 2019
- Upper respiratory infection associated with poor Vitamin D Receptor – Oct 2018
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Gut and airway bionome are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018
- Respiratory Tract Infections in children 7.4 X more likely if poor Vitamin D Receptor – 2008
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Vitamin D Receptor problems occur 5 times for often with Nasal polyposis – Nov 2016
- Vitamin D effects on lung immunity and respiratory diseases – 2011
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
- 2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015
- Strong Vitamin D deficiency associations in Asthma patients – Nov 2014
- Epigenetics and Vitamin D – many studies
Download the PDF fromSci-Hub via VitaminDWiki
BACKGROUND:
Vitamin D and its receptor (VDR) have important roles in perinatal lung development. The objective of this study was to investigate the possible association between VDR FokI and TaqI polymorphism and development of respiratory distress syndrome (RDS) in preterm infants.
METHOD:
A total of 173 premature infants < 34 weeks: 82 with RDS and 91 without RDS were enrolled. Genotyping of VDR polymorphisms were assayed by real-time PCR. Serum 25-hydroxyvitamin D (25-OHD) levels were measured by ELISA in blood samples that were obtained at the time of admission to the neonatal intensive care unit.
RESULTS:
Gestational age (GA) was significantly lower in RDS group compared to the controls. In univariate analysis, VDR TaqI CT and CC genotypes were associated with the increased risk of RDS (OR = 3.264, p = 0.001, 95% CI = 1.597-6.672 and OR = 5.222, p < 0.001, 95% CI = 2.165-12.597, respectively); while VDR FokI showed no association with RDS. 25-OHD levels in RDS group were significantly lower compared with those in without RDS group (p = 0.002). Serum 25-OHD levels were not significantly different among the different FokI and TaqI genotypes.
CONCLUSIONS:
This is the first report of association of VDR polymorphism with RDS development in preterm neonates. Current study suggests that VDR TaqI polymorphism may be involved in predisposition to RDS in premature neonates. Further studies are needed to assess the contribution of vitamin D and VDR signaling to the pathogenesis RDS.
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