Loading...
 
Toggle Health Problems and D

Poor oral health increases CVD risk if low Vitamin D – June 2023

Oral health and 10-year cardiovascular risk in US adults: mediating role of inflammatory diet and vitamin D

LClin Oral Investig. 2023 Jun 5. doi: 10.1007/s00784-023-05097-w   PDF is behind a paywall
ing Wang # 1, Xuanzhi Wang # 2, Mengzi Sun 1, Xuhan Wang 1, Xiaotong Li 1, Wenyu Hu 1, Yixue Yang 1, Jing Li 1, Yibo Dong 1, Bo Li 3

Objective: To investigate whether E-DII or vitamin D mediates the relationship between oral health and cardiovascular disease (CVD) risk.

Methods: This study involved 6616 participants aged over 30 years old from the National Health and Nutrition Examination Survey (NHANES) in 2009-2014. Dietary inflammation and 10-year CVD risk were evaluated via the Energy-adjusted Dietary Inflammatory Index (E-DII) and the Framingham Risk Score (FRS), respectively. We used correlation analysis and mediation analysis to investigate the role of dietary inflammation and vitamin D in the relationship between oral health and CVD risk.

Results: Oral health indicators and CVD risk were positively correlated with E-DII (r > 0, P < 0.001) and negatively correlated with vitamin D levels (r < 0, P < 0.001). The estimated mediating role of E-DII and vitamin D in the overall association between oral health and 10-year risk of CVD ranged from 4.9 to 7.5% and 6.6 to 11.6%, respectively. Furthermore, the mediation proportion of E-DII and vitamin D levels in the total association between oral health indicators and FRS were increased in participants without periodontitis.

Conclusion: Both E-DII and serum vitamin D were mediated the association between oral problems and 10-year CVD risk, especially in participants without periodontitis. Among them, E-DII played a positive mediating role, and serum vitamin D levels was a negative mediator.

Clinical relevance: Anti-inflammatory diet and prevention of vitamin D deficiency might reduce the impact of oral problems on cardiovascular disease risk to some extent. The study highlights the important role of oral health and dietary inflammation and vitamin D in primary prevention of cardiovascular disease.

References
  1. Richards NC et al (2016) Disability, noncommunicable disease and health information. Bull World Health Organ 94(3):230–232 - DOI - PubMed - PMC
  2. Virani SS et al (2020) Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation 141(9):e139–e596 - DOI - PubMed
  3. Ritchey MD et al (2018) Vital signs: state-level variation in nonfatal and fatal cardiovascular events targeted for prevention by million hearts 2022. MMWR Morb Mortal Wkly Rep 67(35):974–982 - DOI - PubMed - PMC
  4. D’Agostino RB Sr et al (2008) General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 117(6):743–753 - DOI - PubMed
  5. Kassebaum NJ et al (2014) Global burden of severe periodontitis in 1990–2010: a systematic review and meta-regression. J Dent Res 93(11):1045–1053 - DOI - PubMed - PMC
  6. Monsarrat P et al (2016) Clinical research activity in periodontal medicine: a systematic mapping of trial registers. J Clin Periodontol 43(5):390–400 - DOI - PubMed
  7. Romandini M et al (2021) Periodontitis, edentulism, and risk of mortality: a systematic review with meta-analyses. J Dent Res 100(1):37–49 - DOI - PubMed
  8. Johansson-Persson A et al (2014) A high intake of dietary fiber influences C-reactive protein and fibrinogen, but not glucose and lipid metabolism, in mildly hypercholesterolemic subjects. Eur J Nutr 53(1):39–48 - DOI - PubMed
  9. Shivappa N et al (2014) Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr 17(8):1689–1696 - DOI - PubMed
  10. O’Neil A et al (2015) Pro-inflammatory dietary intake as a risk factor for CVD in men: a 5-year longitudinal study. Br J Nutr 114(12):2074–2082 - DOI - PubMed - PMC
  11. Ji M et al (2020) Dietary inflammatory index and cardiovascular risk and mortality: a meta-analysis of cohort studies. Medicine (Baltimore) 99(20):e20303 - DOI - PubMed
  12. Woelber JP et al (2016) An oral health optimized diet can reduce gingival and periodontal inflammation in humans - a randomized controlled pilot study. BMC Oral Health 17(1):28 - DOI - PubMed - PMC
  13. Guo J et al (2017) Vitamin D intake and risk of CVD and all-cause mortality: evidence from the Caerphilly Prospective Cohort Study. Public Health Nutr 20(15):2744–2753 - DOI - PubMed
  14. Fry CM, Sanders TA (2015) Vitamin D and risk of CVD: a review of the evidence. Proc Nutr Soc 74(3):245–257 - DOI - PubMed
  15. USC, B (2008) Current Population Survey(CPS) - definitions and explanations
  16. Wong ND (2020) Cardiovascular risk assessment: the foundation of preventive cardiology. Am J Prev Cardiol 1:100008 - DOI - PubMed - PMC
  17. Eke PI et al (2010) Accuracy of NHANES periodontal examination protocols. J Dent Res 89(11):1208–1213 - DOI - PubMed
  18. Eke PI et al (2012) Update of the case definitions for population-based surveillance of periodontitis. J Periodontol 83(12):1449–1454 - DOI - PubMed - PMC
  19. Mora JR, Iwata M, von Andrian UH (2008) Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 8(9):685–698 - DOI - PubMed - PMC
  20. Strozyk D, Gress TM, Breitling LP (2018) Smoking and bone mineral density: comprehensive analyses of the third National Health and Nutrition Examination Survey (NHANES III). Arch Osteoporos 13(1):16 - DOI - PubMed
  21. Aldosari M, Helmi M, Kennedy EN, Badamia R, Odani S, Agaku I, Vardavas C (2020) Depression, periodontitis, caries and missing teeth in the USA, NHANES 2009-2014. Fam Med Community Health 8(4):e000583
  22. Feng Q et al (2021) The role of body mass index in the association between dietary sodium intake and blood pressure: a mediation analysis with NHANES. Nutr Metab Cardiovasc Dis 31(12):3335–3344 - DOI - PubMed
  23. Sanz M et al (2020) Periodontitis and cardiovascular diseases: consensus report. J Clin Periodontol 47(3):268–288 - DOI - PubMed - PMC
  24. Liljestrand JM et al (2015) Missing teeth predict incident cardiovascular events, diabetes, and death. J Dent Res 94(8):1055–1062 - DOI - PubMed
  25. Loos BG et al (2000) Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 71(10):1528–1534 - DOI - PubMed
  26. Paul O et al (2020) Inflammation in periodontal disease: possible link to vascular disease. Front Physiol 11:609614 - DOI - PubMed
  27. Genco RJ, Sanz M (2020) Clinical and public health implications of periodontal and systemic diseases: An overview. Periodontology 2000 83(1):7–13 - DOI - PubMed
  28. Desvarieux M et al (2003) Relationship between periodontal disease, tooth loss, and carotid artery plaque: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Stroke 34(9):2120–2125 - DOI - PubMed - PMC
  29. Salas-Salvadó J et al (2008) Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease. Eur J Clin Nutr 62(5):651–659 - DOI - PubMed
  30. Ramallal R et al (2017) Inflammatory potential of diet, weight gain, and incidence of overweight/obesity: The SUN cohort. Obesity (Silver Spring) 25(6):997–1005 - DOI - PubMed
  31. Tyrovolas S et al (2017) Dietary inflammatory potential is linked to cardiovascular disease risk burden in the US adult population. Int J Cardiol 240:409–413 - DOI - PubMed - PMC
  32. Asadi Z et al (2020) Association between dietary inflammatory index and risk of cardiovascular disease in the Mashhad stroke and heart atherosclerotic disorder study population. IUBMB Life 72(4):706–715 - DOI - PubMed
  33. Moreira AP et al (2012) Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia. Br J Nutr 108(5):801–809 - DOI - PubMed
  34. Bayston KF, Cohen J (1990) Bacterial endotoxin and current concepts in the diagnosis and treatment of endotoxaemia. J Med Microbiol 31(2):73–83 - DOI - PubMed
  35. Laugerette F et al (2011) Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation. J Nutr Biochem 22(1):53–59 - DOI - PubMed
  36. Crowley SD (2014) The cooperative roles of inflammation and oxidative stress in the pathogenesis of hypertension. Antioxid Redox Signal 20(1):102–120 - DOI - PubMed - PMC
  37. Messner B, Bernhard D (2014) Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler Thromb Vasc Biol 34(3):509–515 - DOI - PubMed
  38. Botelho J, Machado V, Proença L, Delgado AS, Mendes JJ (2020) Vitamin D deficiency and oral health: a comprehensive review. Nutrients 12(5):1471
  39. Parikh S et al (2012) Circulating 25-hydroxyvitamin D concentrations are correlated with cardiometabolic risk among American black and white adolescents living in a year-round sunny climate. Diabetes Care 35(5):1133–1138 - DOI - PubMed - PMC
  40. Calton EK, Keane KN, Soares MJ (2015) The potential regulatory role of vitamin D in the bioenergetics of inflammation. Curr Opin Clin Nutr Metab Care 18(4):367–373 - DOI - PubMed

VitaminDWiki – Dental category contains

116 Dental items

Some Dental studies

64,000 items result from query of "oral health" (cardiovascular OR CVD)

Google Scholar

Poor oral health increases CVD risk if low Vitamin D – June 2023        
914 visitors, last modified 05 Jun, 2023,
Printer Friendly Follow this page for updates
Cardiovascular 484 Dental 110
Page actions
Print
Edit