MS flu-like symptoms resulting from interferon-beta were reduced with vitamin D – June 2013

Vitamin D supplementation for patients with multiple sclerosis treated with interferon-beta:
a randomized controlled trial assessing the effect on flu-like symptoms and immunomodulatory properties

BMC Neurology 2013, 13:60 doi:10.1186/1471-2377-13-60; Published: 14 June 2013
Daniel Golan, Basheer Halhal, Lea Glass-Marmor, Elsebeth Staun-Ram, Orit Rozenberg, Idit Lavi, Sara Dishon, Mira Barak, Sophia Ish-Shalom and Ariel Miller

Background: Flu-like symptoms (FLS) are common side effects of interferon beta (IFN-beta) treatment in patients with Multiple Sclerosis (PwMS) and are associated with post-injection cytokine surge.
We hypothesized that vitamin D3 supplementation would ameliorate FLS by decreasing related serum cytokines' levels.

Methods: In a randomized, double blind study of 45 IFNbeta-treated PwMS, 21 patients were assigned to 800 IU of vitamin D3 per day (low dose), while 24 patients received 4,370 IU per day (high dose) for one year. FLS were assessed monthly by telephonic interviews. Serum levels of 25-hydroxy-D (25-OH-D), calcium, PTH, IL-17, IL-10 and IFN-gamma were measured periodically. EDSS, relapses, adverse events and quality of life (QoL) were documented.

Results: 25-OH-D levels increased to a significantly higher levels and PTH levels decreased in the high dose group. There was no significant change in FLS. IL-17 levels were significantly increased in the low dose group, while patients receiving high dose vitamin D had a heterogeneous IL-17 response. No significant differences in relapse rate, EDSS, QoL, serum IL-10 and IFNgamma were found. Hypercalcemia or other potential major adverse events were not observed.

Conclusion: Vitamin D supplementation to IFN-beta treated PwMS, at the doses used, seems safe and associated with dose-dependent changes in IL-17 serum levels, while not affecting IFN-beta related FLS.
Trial registration: ClinicalTrials.gov ID: NCT01005095

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PDF is attached at the bottom of this page

Note: not daily dose: 75,000 IU of vitamin D3 solution every 3 weeks

See also VitaminDWiki

• Overview MS and vitamin D
• 98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon -May 2013
• 3X more vitamin D from the sun if take MS drug Interferon-β – July 2012

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