Vitamin D in immune regulation
and diabetes mellitus – Chapter 22
Ihor Shymanskyi, Olha Lisakovska, Dmytro Labudzinskyi, Anna Mazanova and Mykola Veliky
Department of Biochemistry of Vitamins and Coenzymes, Palladin Institute of Biochemistry of National
Academy of Sciences of Ukraine, Kyiv, Ukraine
22.1 Introduction | 428 |
22.2 Vitamin D synthesis and activation | 428 |
22.3 Role of vitamin D in immune regulation and inflammatory responses | 432 |
22.3.1 Vitamin D and innate immunity | 432 |
22.3.2 Vitamin D and adaptive immunity | 433 |
22.3.3 Cytokines in regulation of vitamin D-metabolizing enzymes | 434 |
22.4 Vitamin D and diabetes mellitus | 435 |
22.4.1 Vitamin D modulates β-cell function | 435 |
22.4.2 Vitamin Dauto/paracrine system in diabetes mellitus | 437 |
22.4.3 Antiinflammatory effect of vitamin D in diabetes mellitus | 438 |
22.5 Conclusions | 442 |
References (at bottom of VitaminDWiki page) | 443 |
- Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018
- Diabetic inflammation reduced by Vitamin D – meta-analysis Feb 2018
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
553 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
- Dark Skin
24 ; Intervention 57 ; Meta-analysis 40 ; Obesity 36 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 13 ; Magnesium 30 Click here to see details Some Diabetes studies
- Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024
- Diabetes and Vitamin D meta-analyses - many studies 39+ as of Nov 2024
- 99.7% of people who got Diabetes had been regularly consuming food emulsifiers - May 2024
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetic Epidemic- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
Chart from the web (2018?)
Immunity category starts with
273 items in Immunity category see also
Virus category listing has1401 items along with related searches Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
228 VitaminDWiki pages contained "infection" in title (June 2024)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
Only the brain is more complex, nothing about Vitamin D
18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection
52 studies are in both Immunity and Virus categories  Download the PDF from Sci-Hub via VitaminDWiki
Diabetes increases the expression (2) of CPY24A1
which destroys Vitamin D after it is seen by Vit D blood test
Thus preventing Vitamin D from benefiting tissues
(3) Addition of Vitamin D decreases the CYP24A1 expression
References
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- Ali, T., El Esawy, B., Elaskary, A., 2018. Effect of paricalcitol on pancreatic oxidative stress, inflammatory markers, and glycemic status in diabetic rats. Ir. J. Med. Sci. 187, 75—84.
- Barragan, M., Good, M., Kolls, J., 2015. Regulation of dendritic cell function by vitamin D. Nutrients 7, 8127—8151.
- Barrat, F., Cua, D., Boonstra, A., Richards, D., Crain, C., Savelkoul, H., et al., 2002. In vitro generation of interleukin 10-producing regulatory CD4 1 T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J.Exp. Med. 195, 603—616.
- Bhalla, A.K., Paavonen, T., Williams, M., Delves, P., Lydyard, P., 1991. Regulation of interleukin-1 and tumour necrosis factor gene expression in myelomonocytic cell lines by 1,25-dihydroxyvitamin D3. Immunology 72, 61 — 64.
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