Medicine 102(1):p e32575, January 06, 2023. | DOI: 10.1097/MD.0000000000032575
Yang, Maoquan MSa,b; Ji, Wansheng PhDa,c; Xu, Ning MSb; zong, Chuanju MSb; Gu, Jinhua MSb; Guo, Xiaojing MSb; Zhang, Li MSa,*
Background:
Recent studies have reported an association between vitamin D receptor (VDR) polymorphisms and colorectal cancer (CRC) risk; however, the results are controversial. This meta-analysis was performed to investigate whether the Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI polymorphisms were correlated with CRC susceptibility.
Methods:
All potential studies were retrieved by searching the PubMed, EMBASE, and Cochrane Library databases through October 2, 2021. Odds ratios (ORs) with 95% confidence intervals were used to evaluate the correlation between VDR gene Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI polymorphisms and CRC risk.
Results:
In this meta-analysis, the BsmI variant was significantly correlated with a lower risk of CRC, especially in Caucasian population (
- B vs b: OR 0.94, 95%CI 0.90–0.99;
- BB vs bb: OR 0.88; 95%CI 0.79–0.97;
- BB vs Bb/bb: OR 0.89; 95%CI 0.81–0.98).
A statistically significant result from the FokI polymorphism was observed in colon cancer rather than rectal cancer(
- Ff vs FF: OR 0.86, 95%CI 0.84–0.93;
- ff/Ff vs FF: OR 0.88, 95%CI 0.79–0.98;
- ff vs Ff/FF: OR 0.90, 95%CI 0.82–0.99).
Similarly, Cdx-2 polymorphism was found to be associated with decreased CRC risk among Africans (C vs c: OR 0.50, 95%CI 0.33–0.75; CC vs cc: OR 0.09, 95%CI 0.01–0.77; Cc vs cc: OR 0.49, 95%CI 0.30–0.81; CC/Cc vs cc: OR 0.45, 95%CI 0.28–0.74,).
Conclusion:
Our findings indicate that VDR polymorphisms are significantly associated with CRC risk.
VitaminDWiki - 13 studies in both categories Colon Cancer and Vitamin D Receptor
This list is automatically updated
VitaminDWiki – Cancer - Colon category contains
VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators
81+ VitaminDWiki VDR pages with CANCER in the title
Note:.Many Cancers protect themselves by deactivating the VDR
This list is automatically updated
Items found: 90
Title |
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Modified |
Breast Cancer prevented in 5 ways via the Vitamin D Receptor – Oct 2024 |
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02 Nov, 2024 |
Poor Vitamin D Receptor does not increase the risk of Breast Cancer (but the opposite is true) – umbrella meta-analysis Sept 2024 |
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06 Sep, 2024 |
Pancreatic Cancer protects itself deactivating HNF4A (which can be reactivated by the Vitamin D Receptor) – April 2024 |
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29 Jul, 2024 |
Lung Cancer risk increases if low Vitamin D, poor activation of Vitamin D Receptor which affects the CALB1 gene – June 2024 |
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29 Jun, 2024 |
Vitamin D Receptor (Cancers OR Viruses) - many studies |
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02 Mar, 2024 |
Oral Cancer and Vitamin D and VDR - several studies |
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11 Feb, 2024 |
Breast Cancer risk reduced if consume butyrate - Dec 2023 |
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23 Jan, 2024 |
An activated Vitamin D Receptor fights Autoimmune Diseases, Infections, Cancers, etc. – Dec 2023 |
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13 Jan, 2024 |
Cervical Cancer is prevented by Vitamin D, and treated if caught early (genes are important) – May 2023 |
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27 May, 2023 |
Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022 |
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06 Dec, 2022 |
Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022 |
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31 Oct, 2022 |
2X more Thyroid Cancer malignancy if less than 15 ng of vitamin D – June 2012 |
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16 Sep, 2022 |
Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022 |
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15 Aug, 2022 |
Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022 |
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27 Jul, 2022 |
Breast Cancer, Vitamin D, and genes – Welsh Nov 2021 |
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09 Feb, 2022 |
How cancer is fought by Vitamin D (Ovarian this time) - Feb 2020 |
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01 Nov, 2021 |
Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021 |
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25 Oct, 2021 |
Cancers and Vitamin D Receptors, including change with race – Feb 2021 |
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24 Oct, 2021 |
Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies |
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18 Oct, 2021 |
After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021 |
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20 Aug, 2021 |
Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021 |
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10 Jul, 2021 |
Oral Cancers - increased risk if low vitamin D or poor vitamin D genes |
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22 Jan, 2021 |
Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021 |
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15 Jan, 2021 |
Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020 |
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09 Dec, 2020 |
Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020 |
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02 May, 2020 |
Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020 |
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22 Jan, 2020 |
8 ways that Cancer might be prevented by Vitamin D - June 2019 |
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26 Dec, 2019 |
Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 |
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14 Dec, 2019 |
Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 |
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15 Nov, 2019 |
Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 |
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09 Nov, 2019 |
Cancer is leading cause of death - Vitamin D and Receptor activators help |
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09 Nov, 2019 |
Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019 |
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06 Nov, 2019 |
Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019 |
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19 Oct, 2019 |
Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019 |
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23 Aug, 2019 |
Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019 |
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29 Jul, 2019 |
Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies |
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14 Jun, 2019 |
Blood cell cancer is associated with a 3X worse Vitamin D Receptor – June 2019 |
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14 Jun, 2019 |
Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019 |
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13 Jun, 2019 |
After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019 |
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04 Jun, 2019 |
Effects of Resveratrol against Lung Cancer in mice – Nov 2017 |
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28 Apr, 2019 |
The Role of Resveratrol in Cancer Therapy – Dec 2017 |
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27 Apr, 2019 |
Good Vitamin D receptor reduced bladder cancer and cisplatin deaths – April 2019 |
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11 Apr, 2019 |
A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019 |
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26 Mar, 2019 |
Breast Cancer and Vitamin D review – March 2018 |
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17 Mar, 2019 |
Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018 |
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15 Mar, 2019 |
Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019 |
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11 Feb, 2019 |
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 |
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09 Dec, 2018 |
Ovarian Cancer risk reduced if higher vitamin D, more UVB, or better vitamin D receptor – Nov 2018 |
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10 Nov, 2018 |
Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018 |
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01 Nov, 2018 |
Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010 |
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03 Oct, 2018 |
Pancreatic Cancer – live a year longer if have high vitamin D and good Vitamin D Receptor – Aug 2018 |
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15 Aug, 2018 |
Endometriosis, Endometrial Cancer, and poor Vitamin D or Receptor – Aug 2018 |
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08 Aug, 2018 |
Risk of colon cancer increases in mice with no Vitamin D receptor in colon - July 2018 |
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07 Jul, 2018 |
Vitamin D receptor is essential for both normal and cancerous cells in the lab – June 2018 |
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16 Jun, 2018 |
Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018 |
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28 Mar, 2018 |
Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018 |
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17 Mar, 2018 |
Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017 |
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14 Dec, 2017 |
Nonmelanoma Skin Cancer 2X more likely if poor Vitamin D Receptor – Oct 2017 |
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19 Oct, 2017 |
Cancer and the Vitamin D Receptor, a primer – Sept 2017 |
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01 Oct, 2017 |
Thyroid Cancer rate has increased 3X in 3 decades, Vitamin D Receptor decreases, Calcium increases – Aug 2017 |
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26 Aug, 2017 |
Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017 |
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19 Aug, 2017 |
Cancer risks and Vitamin D Receptors – association is unclear – 2017 |
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19 Aug, 2017 |
Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016 |
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09 Aug, 2017 |
Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017 |
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02 Aug, 2017 |
Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 |
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27 Jul, 2017 |
Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 |
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25 Jul, 2017 |
Gastric Cancer 2.7 X more likely if poor Vitamin D Receptor (Chinese) – 2015 |
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15 Jun, 2017 |
Skin Cancers, Vitamin D, Vitamin D Receptor and Genes – Jan 2015 |
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17 Mar, 2017 |
Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017 |
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06 Mar, 2017 |
2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017 |
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04 Mar, 2017 |
Urinary Bladder Cancer survival is associated with vitamin D receptor: 14 months vs 53 months – Oct 2015 |
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02 Mar, 2017 |
Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017 |
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01 Mar, 2017 |
Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013 |
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27 Feb, 2017 |
Vitamin D receptor may suppress skin cancer – Dec 2013 |
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27 Jan, 2017 |
Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017 |
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28 Dec, 2016 |
Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016 |
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06 Dec, 2016 |
Vitamin D, Vitamin D Receptor and Cancer – Nov 2016 |
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05 Dec, 2016 |
High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016 |
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14 Nov, 2016 |
2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013 |
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14 Nov, 2016 |
Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 |
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12 Nov, 2016 |
10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 |
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23 Sep, 2016 |
Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013 |
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17 Mar, 2016 |
Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015 |
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06 Jan, 2016 |
Pancreatic Cancer treatment by calcipotriol (a synthetic vitamin D) improves outcome by 57 percent – Sept 2014 |
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13 Dec, 2015 |
Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015 |
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18 Oct, 2015 |
Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015 |
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03 May, 2015 |
Free vitamin D (VDR) may be more important than total for bladder cancer – March 2013 |
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06 Jan, 2014 |
Genes breast cancer and vitamin D receptor - Sept 2010 |
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08 Jul, 2013 |
Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012 |
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08 Jul, 2013 |
Vitamin D receptor in breasts and breast cancer vary with race – March 2013 |
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08 Jul, 2013 |