Can Vitamin D Supplementation Improve Physical Function and Quality of Life in Older Patients With Heart Failure?
Circulation: Heart Failure. 2010;3:183-184
doi: 10.1161/CIRCHEARTFAILURE.110.943944
Emily B. Levitan, ScD and Suzanne E. Judd, PhD
From the Departments of Epidemiology (E.B.L.) and Biostatistics (S.E.J.), University of Alabama at Birmingham School of Public Health, Birmingham, Ala.
Correspondence to Emily B. Levitan, ScD, Department of Epidemiology, University of Alabama at Birmingham, RPHB 230K, 1530 3rd Avenue S, Birmingham, AL 35294-0022. E-mail elevitan at uab.edu
An extract of the first 250 words of the full text is provided, because this article has no abstract.
Although early research on vitamin D focused on the effects of vitamin D deficiency on bone metabolism, more recent work has found a vast variety of roles for vitamin D throughout the body.1 Studies suggest that too little vitamin D might increase the risk for conditions as diverse as cardiovascular disease, cancer, autoimmune disease, and depression.1 The optimal level of vitamin D is not known, but there is general agreement that serum 25-hydroxyvitamin D <50 nmol/L (20 ng/mL) represents deficiency.1 However, some researchers have suggested that levels >80 nmol/L may be required for optimal health.2
Article see p 195
Vitamin D deficiency is common in patients with heart failure,3 and adequate vitamin D may reduce disease progression and symptom severity through suppression of the renin-angiotensin-aldosterone system,3 suppression of parathyroid hormone,3 reduction of cardiac remodeling,4 and improvement in muscle strength.1 As an adjunct to pharmacological treatment of heart failure, vitamin D supplementation is appealing. Vitamin D can be obtained from sun exposure, over-the-counter dietary supplements, and prescription formulations. It has several potential additional benefits, including reducing the risk for falls, and few known adverse effects until high serum concentrations are reached (25-hydroxyvitamin D ?374 nmol/L).1
In this issue of Circulation: Heart Failure, Witham et al5 present the results of a randomized, double-blind, placebo-controlled trial testing the hypothesis that intermittent vitamin D supplementation improves physical function, as assessed with a 6-minute walk test, in older patients with systolic heart failure. Secondary outcomes include the timed up-and-go test, the Functional Limitation Profile, . . .
See also VitaminDWiki
Cardiovascular category starts with the following
Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022
- Overview Cardiovascular and vitamin D
- Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
- Coronary Artery Disease and Vitamin D - many studies 18+
- Cardiovascular problems reduced by Omega-3 - many studies 34+
- Arteries and Atherosclerosis and Vitamin D - many studies 71+
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
- Statins and Vitamin D - many studies 25+
- Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and Vitamin D - many studies statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
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