- Therapeutic high-dose vitamin D for vitamin D-deficient severe COVID-19 disease: randomized, double-blind, placebo-controlled study (SHADE-S)
- Note: Cost of Vitamin D: $2.40 = 12 X 20 cents for each of 50,000 IU capsules
- Note: Vitamin D level of placebo group fell from 13 ng to 4 ng by day 7
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Therapeutic high-dose vitamin D for vitamin D-deficient severe COVID-19 disease: randomized, double-blind, placebo-controlled study (SHADE-S)
J Public Health (Oxf) 2024 Jan 30:fdae007. doi: 10.1093/pubmed/fdae007 PDF is behind a $55 paywall
Ajay Singh 1, Ashu Rastogi 2, Goverdhan Dutt Puri 1, Venkata Ganesh 1, Naveen Bal Naik 1, Kamal Kajal 1, Shubhkarman Kahlon 1, Shiv Lal Soni 1, Narender Kaloria 1, Kulbhushan Saini 1, Amarjyoti Hazarika 1, Varun Mahajan 1, Karan Singla 1, Sanjay Bhadada 2, Vaishali Soni 3 (India)
- History: Study completed Dec 2021, Study Received: 01 May 2023, Revision received: 06 December 2023, Accepted: 29 December 2023, Published: 30 January 2024
Background: efficacy of therapeutic cholecalciferol supplementation for severe COVID-19 is sparingly studied.
Objective: effect of single high-dose cholecalciferol supplementation on sequential organ failure assessment (SOFA) score in moderate-to-severe COVID-19.
Methods: participants with moderate to severe COVID-19 with PaO2/FiO2 ratio < 200 were randomized to 0.6 million IU cholecalciferol oral (intervention) or placebo.
Outcomes: primary outcome was change in Day 7 SOFA score and pre-specified secondary outcomes were SOFA and 28-day all-cause mortality.
Results: in all, 90 patients (45 each group) were included for intention-to-treat analysis. 25(OH)D3 levels were 12 (10-16) and13 (12-18) ng/ml (P = 0.06) at baseline; and 60 (55-65) ng/ml and 4 (1-7) ng/ml by Day 7 in vitamin D and placebo groups, respectively.
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Vitamin D levels in ng/mL
| Group | Baseline | Day 7 |
| Vitamin D | 12 (10-16) | 60 (55-65) |
| Placebo | 13 (12-18) | 4 (1-7) |
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The SOFA score on Day 7 was better in the vitamin D group [3 (95% CI, 2-5) versus 5 (95% CI, 3-7), P = 0.01, intergroup difference - 2 (95% CI, -4 to -0.01); r = 0.4].
A lower all-cause 28-day mortality [24% compared to 44% (P = 0.046)] was observed with vitamin D.
Conclusions: single high-dose oral cholecalciferol supplementation on ICU admission can improve SOFA score at Day 7 and reduce in-hospital mortality in vitamin D-deficient COVID-19. ClinicalTrials.gov id: NCT04952857 registered dated 7 July 2021. What is already known on this topic-vitamin D has immunomodulatory role. Observational and isolated intervention studies show some benefit in COVID-19. Targeted therapeutic vitamin D supplementation improve outcomes in severe COVID-19 is not studied in RCTs. What this study adds-high-dose vitamin D supplementation (0.6 Million IU) to increase 25(OH)D > 50 ng/ml is safe and reduces sequential organ failure assessment score, in-hospital mortality in moderate to severe COVID-19. How this study might affect research, practice or policy-vitamin D supplementation in vitamin D-deficient patients with severe COVID-19 is useful may be practiced.
Note: Cost of Vitamin D: $2.40 = 12 X 20 cents for each of 50,000 IU capsules
Note: Vitamin D level of placebo group fell from 13 ng to 4 ng by day 7
The body quickly consumes a lot of Vitamin D to fight viruses, surgeries, etc,
VitaminDWiki - Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
Very cost-effective to give Vitamin D to everyone who has COVID infection than to wait till they enter the ICU
22+ VitaminDWiki Virus pages have VITAMIN and RCT in the title
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VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
As of March 31, 2024, the VitaminDWiki COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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Efficacy of All COVID treatments (not just Vitamin D) are reduced by half 4 days after onset
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