COVID death 12X more likely if poor Vitamin D Receptor (less D gets to cells) - many studies

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COVID death 12X more likely if poor VDR - Oct 2021

Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients
Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases - October 2021
Rasoul AbdollahzadehMohammad Hossein ShushizadehMina Barazandehrokh...Razieh Zarifian Yeganeh

Introduction Growing evidence documented the critical impacts of vitamin D (VD) in the prognosis of COVID-19 patients. The functions of VD are dependent on the vitamin D receptor (VDR) in the VD/VDR signaling pathway. Therefore, we aimed to assess the association of VDR gene polymorphisms with COVID-19 outcomes. Methods In the present study, eight VDR single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 500 COVID-19 patients in Iran, including 160 asymptomatic, 250 mild/moderate, and 90 severe/critical cases. The association of these polymorphisms with severity, clinical outcomes, and comorbidities were evaluated through the calculation of the Odds ratio (OR). Results Interestingly, significant associations were disclosed for some of the SNP-related alleles and/or genotypes in one or more genetic models with different clinical data in COVID-19 patients. Significant association of VDR-SNPs with signs, symptoms, and comorbidities was as follows: ApaI with shortness of breath (P ˂ 0.001) and asthma (P = 0.034) in severe/critical patients (group III); BsmI with chronic renal disease (P = 0.010) in mild/moderate patients (group II); Tru9I with vomiting (P = 0.031), shortness of breath (P = 0.04), and hypertension (P = 0.030); FokI with fever and hypertension (P = 0.027) in severe/critical patients (group III); CDX2 with shortness of breath (P = 0.022), hypertension (P = 0.036), and diabetes (P = 0.042) in severe/critical patients (group III); EcoRV with diabetes (P ˂ 0.001 and P = 0.045 in mild/moderate patients (group II) and severe/critical patients (group III), respectively). However, the association of VDR TaqI and BglI polymorphisms with clinical symptoms and comorbidities in COVID-19 patients was not significant. Conclusion VDR gene polymorphisms might play critical roles in the vulnerability to infection and severity of COVID-19, probably by altering the risk of comorbidities. However, these results require further validation in larger studies with different ethnicities and geographical regions.

Uni- and multivariate logistic regression analyses (clipped from PDF)

Univariate analysis showed that disease severity was associated with age (odds ration [OR]: 1.031, confidence interval CI: 1.015-1.047, p < .001, R2: 2.7%), lymphocyte count (OR: 0.998, CI: 0.997-0.998, p < .001, R2: 6.7%), ferritin (OR: 1.001, CI: 1.000-1.002, p < .001, R2: 7.9%), LDH (OR: 1.003, CI: 1.002-1.005, p < .001, R2: 8.5%), hs-CRP levels (OR: 1.016, CI: 1.012-1.019, p < .001, R2: 18.1%), procalcitonin (OR: 2.902, CI: 1.651-5.099, p <.001, R2: 8.7%), and also Fok I Ff genotype (OR: 3.172, CI: 1.182-8.511, p = .022, R2: 1.1%).

In univariate analysis, mortality was associated with the Apa I aa genotype (OR: 11.828, CI: 2.493-56.104, p = .002, R2: 14.6%). Moreover, ICU admission was associated with theTaqI TT genotype (OR: 2.854, CI: 0.851-10.755, p = .005, R2: 3.8%).

In multivariate logistic regression analysis, hs-CRP (OR: 1.016), ApaI aa genotype (OR: 14.581) were found to be related to mortality (R2: 37.1%).

 Download the PDF from VitaminDWiki

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COVID death 11.8X more likely if poor VDR - Review Nov 2022

Vitamin D and polymorphisms of VDR and GC genes in the severity and mortality from COVID-19. A systematic review
Nutr Hosp. 2022 Nov 3.doi: 10.20960/nh.04299
[Article in Spanish] Giulia Camporesi 1 , Regina Hernández Payró 1 , Tania Levy Esses 1 , María José Peláez Samperio 1 , Adrián Macho González 2 , Francisco J Sánchez-Muniz 2

Previous studies have pointed to a possible relationship between vitamin D deficiency and the severity of the disease promoted by SARS-CoV-2, reducing respiratory and cardiovascular complications caused by a hyperreaction of the immune system known as "cytokine storm". This vitamin exerts multiple functions that depend on the presence and levels of different proteins, such as the vitamin D receptor (VDR) and the vitamin D binding protein (DBP), and the existence of single nucleotide polymorphisms (SNPs) of the genes that encode these proteins. The objective of this review is to assess whether some VDR and GC SNPs are risk factors for the most severe forms of COVID-19 disease and whether they condition the response to vitamin D supplementation. A search was performed in PubMed, Google Scholar and Scielo, finding that genotypes in patients affected by COVID-19, were rarely performed, although some studies find a relationship between different alleles and the severity of the disease. The ApaI polymorphism of the VDR gene stands out, as the minor allele "a" increases the risk of mortality from COVID-19 (OR = 11.828, CI: 2,493-56,104, p = 0.002). Results divergency in the efficacy of vitamin D supplementation suggest the need for a larger number of studies. In conclusion, the study of VDR and GC polymorphisms seems essential to effectively treat vitamin D deficiency and particularly to protect against COVID-19. Well-designed studies are needed to elucidate whether plasma vitamin D levels play a role of casuality or causality.
 Download the Spanish PDF from VitaminDWiki

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Many viruses and some diseases can down-regulate the Vitamin D Receptor

• A virus that most adults have (Cytomegalovirus) decreases the amount of Vitamin D which gets to the cells – Jan 2017
• Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010
• COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
• Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies

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VitaminDWiki - in both categories Virus and Vitamin D Receptor ( 37 studies)

This list is automatically updated

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VitaminDWiki - The Vitamin D Receptor is associated with many health problems

530 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (14 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

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