Breast Cancer 7.8 times more likely if Vitamin D less than 20 ng (100 women) – May 2017

Association between Vitamin D deficiency and Breast Cancer.

Pak J Med Sci. 2017 May-Jun;33(3):645-649. doi: 10.12669/pjms.333.11753.

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Shaukat N1, Jaleel F2, Moosa FA3, Qureshi NA4.
1 Dr. Noureen Shaukat, MBBS. Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan.
2 Dr. Farhat Jaleel, MBBS, FCPS. Associate Professor, Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan.
3 Prof. Dr. Foad Ali Moosa, MBBS, FRCS. Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan.
4 Dr. Naeem Akhter Qureshi, MBBS, FCPS. Assistant Professor, Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan.

OBJECTIVE:
To determine the association between vitamin D deficiency and breast cancer.

METHODS:
This case control study included 94 female patients aged 20-75 years of any marital status and parity. Newly diagnosed 42 breast cancer patients who presented to surgical OPD of Dow University Hospital from Jan 2016 to June 2016 were included into the study as "cases" after informed consent. Age-matched 52 females who presented to OPD for complain other than breast pathology were included as the "control group". The sociodemographic of both cases and controls and histopathological characteristics of cases were recorded. Serum 25-(OH)2D levels were studied by the ELISA technique and recorded in ng/ml. Vitamin D deficiency was considered at serum level less than 20 ng/ml.

RESULTS:
Mean age was 40.1 Years for controls and 47.6 Years for cases. Mean height, weight and BMI did not differ between cases and controls. Serum Vitamin D levels were significantly lower in cases (85.7%) than controls (55.8%). The unadjusted and adjusted ORs for breast cancer in cases and controls showed a statistically significantly increased risk of breast cancer with low vitamin D concentration (p value 0.003).
After adjustment for age, parity, BMI, sun exposure, economic status and education status the ORs (95% CIs) for breast cancer risk was 7.8 (1.99 - 30.58) for women with vitamin D concentrations <20 ng/mL.

CONCLUSION:
Findings of our study conclude that vitamin D deficiency is associated with risk of breast cancer.

PMID: 28811787 PMCID: PMC5510119 DOI: 10.12669/pjms.333.11753

From the PDF

• “In a study done in Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore , Pakistan vitamin D deficiency was found in 95.6% of breast cancer patients and in 77% of control group.4”
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