UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses
Arteriosclerosis, Thrombosis, and Vascular Biology. 2016;ATVBAHA.116.308063m http://dx.doi.org/10.1161/ATVBAHA.116.308063
Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022
- Overview Cardiovascular and vitamin D
- Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
- Coronary Artery Disease and Vitamin D - many studies 18+
- Cardiovascular problems reduced by Omega-3 - many studies 34+
- Arteries and Atherosclerosis and Vitamin D - many studies 71+
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
- Statins and Vitamin D - many studies 25+
- Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and Vitamin D - many studies statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
Items in both categories Cardiovascular and UV are listed here:
- More Ultraviolet Radiation, Less Cardiovascular Disease – Aug 2024
- UV reduces cardiovascular and metabolic problems– Vitamin D plus Nitric oxide – Sept 2023
- UVB phototherapy (which increases Vitamin D and VDR) decreased risk of many heart and stroke problems – July 2020
- Atherosclerosis prevented by Ultraviolet light (UVB in mice) – Oct 2016
- Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013
Items in both categories Cardiovascular and Inflammation are listed here:
- Vitamin D reduces autoimmune, cardio, and metabolic Inflammation – Nov 2024
- Earthing proven by RCTs to work - improves sleep, reduces blood viscosity, etc.
- Risk of Cardiovascular disease: Low Vitamin D, low HSPCs and high hsCRP - Jan 2024
- High maternal vitamin D resulted in 12 percent less inflammation (CRP) 20 years later – Oct 2016
- Omega-7 - in addition to Omega-3
- Inflammatory diseases: review of vitamin D, with many tables – May 2014
- Vitamin D reduces inflammation (heat shock protein) – Aug 2012
- 4000 IU vitamin D daily for just 5 days reduced inflammation after heart attack – RCT Jan 2013
- Cardiovascular disease predicted by CRP and vitamin D, not cholesterol – Feb 2012
Naoto Sasaki, Tomoya Yamashita, Kazuyuki Kasahara, Atsushi Fukunaga, Tomoyuki Yamaguchi, Takuo Emoto, Keiko Yodoi, Takuya Matsumoto, Kenji Nakajima, Tomoyuki Kita, Masafumi Takeda, Taiji Mizoguchi, Tomohiro Hayashi, Yoshihiro Sasaki, Mayumi Hatakeyama, Kumiko Taguchi, Ken Washio, Shimon Sakaguchi, Bernard Malissen, Chikako Nishigori and Ken-ichi Hirata
Objective—UVB irradiation is an established treatment for immunoinflammatory cutaneous disorders and has been shown to suppress cutaneous and systemic inflammatory diseases through modulation of the adaptive immune response. However, it remains unknown whether UVB irradiation prevents an immunoinflammatory disease of arteries such as atherosclerosis.
Approach and Results—Here, we show that UVB exposure inhibits the development and progression of atherosclerosis in atherosclerosis-prone mice by expanding and enhancing the functional capacity of CD4+ forkhead box P3+ regulatory T cells and regulating proatherogenic T-cell responses. Experimental studies in Langerhans cell–depleted mice revealed that epidermal Langerhans cells play a critical role in UVB-dependent induction of CD4+ forkhead box P3+ regulatory T cells, suppression of proatherogenic T-cell responses, and prevention of atherosclerotic plaque development.
Conclusions—Our findings suggest the skin immune system as a novel therapeutic target for atherosclerosis and provide a novel strategy for the treatment and prevention of atherosclerosis.
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