1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022

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Association between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals

Nutrients 2021, 13(2), 335; https://doi.org/10.3390/nu13020335
by Kenya Kusunose 1,*ORCID,Yuichiro Okushi 1,Yoshihiro Okayama 2,Robert Zheng 1,Miho Abe 1,Michikazu Nakai 3,Yoko Sumita 3,Takayuki Ise 1,Takeshi Tobiume 1,Koji Yamaguchi 1,Shusuke Yagi 1,Daiju Fukuda 1,Hirotsugu Yamada 4,Takeshi Soeki 1,Tetsuzo Wakatsuki 1 andMasataka Sata 1

A broad range of chronic conditions, including heart failure (HF), have been associated with vitamin D deficiency. Existing clinical trials involving vitamin D supplementation in chronic HF patients have been inconclusive. We sought to evaluate the outcomes of patients with vitamin D supplementation, compared with a matched cohort using real-world big data of HF hospitalization. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). After exclusion criteria, we identified 93,692 patients who were first hospitalized with HF between April 2012 and March 2017 (mean age was 79 ± 12 years, and 52.2% were male). Propensity score (PS) was estimated with logistic regression model, with vitamin D supplementation as the dependent variable and clinically relevant covariates.
On PS-matched analysis with 10,974 patients, patients with vitamin D supplementation had

• lower total in-hospital mortality (6.5 vs. 9.4%, odds ratio: 0.67, p < 0.001) and
• in-hospital mortality within 7 days (0.9 vs. 2.5%, OR, 0.34, and
• in-hospital mortality within 30 days 3.8 vs. 6.5%, OR: 0.56, both p < 0.001)

In the sub-group analysis mortalities in patients with age < 75, diabetes, dyslipidemia, atrial arrhythmia, cancer, renin-angiotensin system blocker, and ß-blocker were not affected by vitamin D supplementation. Patients with vitamin D supplementation had a lower in-hospital mortality for HF than patients without vitamin D supplementation in the propensity matched cohort. The identification of specific clinical characteristics in patients benefitting from vitamin D may be useful for determining targets of future randomized control trials.

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Suspect that something other than Vitamin D might have created the benefit

Example: Vitamin D may have been just one of many things that the person was doing to improve their health

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Pages with HEART FAILURE in title (43 as of April 2022)

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VitaminDWiki Meta-anlysis pages with HEART FAILURE in title

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VitaminDWiki - Cardiovascular category

530 items In Cardiovascular category

Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022

• Overview Cardiovascular and vitamin D
• Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
• Coronary Artery Disease and Vitamin D - many studies 18+
• Cardiovascular problems reduced by Omega-3 - many studies 34+
• Arteries and Atherosclerosis and Vitamin D - many studies 71+
• Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
• Statins and Vitamin D - many studies 25+
• Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
• Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
• Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
• Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
• Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
• Heart attack ICU costs cut in half by Vitamin D – Oct 2018
• Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022