Gut-Friendly Vitamin D

The article at the bottom of this page got VitaminDWiki interested in gut-friendly forms of Vitamin D

Bio-D-Mulsion Forte® from Biotics Research Corporation (The first one on the market)

supplies 2,000 IU per drop of vitamin D3 as a micro-emulsion for enhanced absorption and utilization, which is particularly important for those with malabsorption conditions. "
$21 Amazon Sept 2018

• Biotics Research Description fo the 2,000 IU/ drop FORTE

CLICK HERE for details and updates on Bio-D-Mulsion Forte
Also - see bottom of this page

Subsequent D3 Emulsions on Amazon with 2,000 IU/drop

1,000 servings per bottle. approximately 5 cents per 5,000 IU = low cost

• Micro D-3 Vitamin D-3-1oz, $23
  • Talked with the manufacturer - extremely knowledgable about emulsions for many nutrients
• Adaptogen Research - Bio-Emulsion-D3 $21
• Preventix Vitamin D3 with SMT: Sub Micron Technolog $20
• D-2000 Micro Emulsion Forte Omnivits $19
• Life Extension Liquid Emulsified Vitamin D3 $34

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Overview Gut and vitamin D contains the following gut-friendly alternatives

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See also VitaminDWiki

• Vitamin D which dissolves in mouth for those having poor response due to poor guts, HSCT etc.- June 2023
• Vitamin D is aided by probiotics (review of RCTs) – Dec 2020
• Extra Vitamin D needed for Crohn's
• All items in Gut and vitamin D 208 items
• IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015
• Powder-based Vitamin D may be gut-friendly (Cystic Fibrosis) – RCT Aug 2017
• Alternatives if not swallow pills or not absorb vitamin D - topical, sublingual, etc.
• 3 X increased risk of being Vitamin D deficient if gut problems while pregnant– March 2018
• Vitamin D Emulsions - nano 2X better than coarse – Dec 2017

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See also web - other forms of vitamin D which also have increased absorption

• Clinical Trial for IBD using 5,000 IU of vitamin D
• Food-grade nanoemulsions: formulation, fabrication, properties, performance . .
  April 2011, 45 pages, but abstract does not have much content. 10.1080/10408398.2011.559558
• Life Extension sells a similar product at about 25% higher cost
• VESIsorb Compares VESIsorb®, Liposomes, Colloid
• Pure ecapsulations Vitamin D3 VESIsorb
  Amazon (US) $29
• D3 Fusion - claims 7X better absorption (than D2?) Rag Tag Research Geeks
  Amazon (US) $34

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In addition to the following 2010 paper, there are two previous papers from 2004 and 2008

  attached at the BOTTOM OF THIS PAGE

The prevalence of suboptimal vitamin D status in a randomly selected cohort of Colorado firefighters - 2010

Vitamin D insufficiency has been associated with increased risk of CVD, various cancers, autoimmune disease and type 2 diabetes.
Despite adequate sun exposure, individuals inhabiting metropolitan areas display a high prevalence of vitamin D insufficiency as determined by serum levels of 25(OH) vitamin D less than 32 ng/mL.

The purpose of this study was to:

• 1. Assess the serum levels of 25(OH) vitamin D and prevalence of vitamin D deficiency in a cohort of 20 firefighters that work and reside in the Denver metro region and
• 2. Perform follow-up lab work after eight weeks supplementation with a microemulsified liquid vitamin D-3 preparation.

The initial baseline blood levels of 25(OH) vitamin D were assessed and the study subjects were advised to take 4,000 IU/daily (two drops) of the vitamin D3 preparation for eight weeks.

After the eight-week supplemental period serum levels were retested to establish the percent increase in the 25(OH) vitamin D blood levels.
The average initial 25(OH) vitamin D blood level and eight-week post test blood levels was 27.02 ng/mL and 54.01 ng/mL, respectively.
Pretest 75 percent of the study subjects were defined as deficient (less than 32 ng/mL) and only 25 percent were deficient after eight weeks of supplementation with the liquid emulsified vitamin D-3. The average percent increase in serum 25(OH) vitamin D levels was 106 percent.

Conclusion: Suboptimal vitamin D status is prevalent in Denver firefighters and eight weeks of 4,000 IU/daily supplementation with a micro-emulsified liquid vitamin D-3 preparation increased blood levels on average 106 percent.

Introduction
Vitamin D deficiency is a serious medical condition that has been associated with an increased risk of developing cardiovascular disease, type 2 diabetes, hypertension, various cancers, and autoimmune diseases.

Vitamin D insufficiency occurs at epidemic levels in many industrialized countries, where exposure to sunlight tends to be limited and diets tend not to include sufficient amounts of foods naturally rich in vitamin D. During 2009, Gerard Guillory, MD, tested more than 1,200 of his patients and found that roughly 90 percent had sub-optimal vitamin D levels, as determined by serum 25(OH) vitamin D levels less than 32 ng/mL.

Guillory achieved great success in treating this with Bio D Mulsion, a microemulsified preparation made by Biotics Research Corporation.
The purpose of this study was to:
1. Increase public and physician awareness of the scope and seriousness of vitamin D deficiency and
2. Assess the effectiveness of the microemulsified vitamin D preparation.

Several preparations have been recommended to patients by physicians for the treatment of vitamin D insufficiency. The availability of vitamin D preparations ranges from high potency tablets, capsules, to liquid forms. Vitamin D is a fat soluble hormone and thus requires biliary secretions to properly saponify the fats for proper intestinal absorption.

To maximize the efficacy and bioavailability of fat soluble nutrients, enhanced delivery methods have been developed. One such method is an oil in water micro-emulsification, a closely-held process that enables a fat soluble (water-insoluble) vitamin to be placed into a uniformly micrometer sized, fat soluble particle that is dispersible in water and capable of intestinal transport independent of bile acid-saponification.

The aim was to ascertain how efficacious two drops, yielding 4,000 IU of micro-emulsified vitamin D-3 would be in raising low serum levels of 25(OH) vitamin D in a group of 20 fire fighters residing in the Denver metro area.

Materials and methods Twenty full-time fire fighters of the Aurora Fire Department were selected on a volunteer basis to participate in an eight-week study during the winter/spring months of 2009.

The 20 subjects were advised to stop consuming multivitamins, cod liver oil and other supplements containing vitamin D upon initiation of the study.
The subjects filled out a medical symptom questionnaire aimed to assess subjective indications of mood, energy level, and digestive complaints.
All subjects had blood drawn (at the Care Group, PC, office of Gerard Guillory MD in Aurora, Colo.) and serum levels of 25- hydroxyvitamin D (25(OH) vitamin D tested through Laboratory Corporation of America (Lab. Corp) via an assay developed by DiaSorin.

The subjects were advised to take 4,000 IU/day (two drops) daily of the liquid emulsified preparation produced by Biotics Research Corporation.
After eight weeks of daily supplementation the study subjects! 25(OH) vitamin D levels were retested by Laboratory Corporation of America.
The subjects also filled out the same medical symptom questionnaire and the data was compiled.

Results The average baseline 25(OH) vitamin D blood level was 27.02 ng/mL. Current medical guidelines suggest that vitamin D insufficiency begins when blood levels are less than 32 ng/mL and optimal disease prevention occurs when blood levels are more than 60 ng/mL (REF).
Only five study subjects had serum levels more than the 32 ng/mL level and two subjects had blood levels less than 11 ng/mL.
The majority of subjects had levels in the low to mid 20s (see table 1).
Prior to supplementation 75 percent of the subject were deficient in vitamin D and 10 percent of the subjects were severely deficient (as defined by blood levels less than 10 ng/mL).

After the eight-week supplemental period the average 25(OH) vitamin D blood level was 54 ng/mL, a 106 percent average increase. Post supplementation 15-study subjects, or 75 percent, had serum levels more than the deficiency blood level of 32 ng/mL (pre-supplementation 75 percent were deficient).
Only five study subjects, or 25 percent, had serum levels less than the 32 ng/mL level. Seven subjects had blood levels above 50 ng/mL, the highest being 114 ng/mL (see table 1).

The prevalence of vitamin D insufficiency in a group of 20 firefighters not taking any vitamin D supplements is 75 percent. Studies show that individuals with vitamin D levels less than 32 ng/mL have an increased risk for developing heart disease, cancers, and autoimmune diseases.

Due to high prevalence of vitamin D insufficiency in firefighters residing in a sunny part of the country, physicians should increase their 25(OH) vitamin D blood testing on a more routine basis among firefighters and lay people alike. Increased screening would likely have a huge health and financial impact, leading to increased work productivity and decreased medical costs through disease prevention.

The form of vitamin D supplementation in deficient individuals should be inexpensive, highly bio-available and easy to use for optimal compliance. In this study the microemulsified Bio D Mulsion Forte from Biotics Research Corporation was used and can be attributable to an average increase of 106 percent in blood levels of the study subjects.

It’s likely that the micro-emulsification process in a liquid delivery form facilitates maximal absorption and bio-availability of the vitamin D supplement. This is evidenced by the consistent increases in blood levels after eight weeks of 4,000 IU/daily use, bringing 75 percent of the study subjects out of the deficiency reference range.
This research was provided by Biotics Research Corporation. 800-231-5777 * www.bioticsresearch.com
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VitaminDWiki wondered if Dan M, the fire-fighter who had such a big improvement in his vitamin D level, above was Black.
Blacks seem to be more efficient at using any amount of vitamin D they can get (dark skin does not get much)
E-mailed to the researcher - who did not know the answer

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