- Vitamin D in Diabetes: Uncovering the Sunshine Hormone's Role in Glucose Metabolism and Beyond
- Risk of 44+ diseases at least double with poor Vitamin D Receptor
- 81+ Vitamin D Receptor pages in VitaminDWiki have CANCER in title
- 14 ways Vitamin D Receptor activation can be increased
- VitaminDWiki - The Vitamin D Receptor is associated with many health problems contains
- VitaminDWiki - 24 studies in both categories Diabetes and Vitamin D Receptor
- 6 Reasons that medical professionals do not prescribe Vitamin D for Diabetes
Vitamin D in Diabetes: Uncovering the Sunshine Hormone's Role in Glucose Metabolism and Beyond
Nutrients 2023, 15, 1997. https: / / doi.org/ 10.3390/nu15081997
Jie Wu 1 , Annette Atkins 2, Michael Downes * and Zong Wei 1,3,*
- Department of Physiology and Biomedical Engineering, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
- Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
- Division of Endocrinology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
* Correspondence: downes at salk.edu (M.D.); wei.zong at mayo.edu (Z.W.)
Over the last decades, epidemiology and functional studies have started to reveal a pivotal role of vitamin D in both type 1 and type 2 diabetes pathogenesis. Acting through the vitamin D receptor (VDR), vitamin D regulates insulin secretion in pancreatic islets and insulin sensitivity in multiple peripheral metabolic organs. In vitro studies and both T1D and T2D animal models showed that vitamin D can improve glucose homeostasis by enhancing insulin secretion, reducing inflammation, reducing autoimmunity, preserving beta cell mass, and sensitizing insulin action.
Conversely, vitamin D deficiency has been shown relevant in increasing T1D and T2D incidence. While clinical trials testing the hypothesis that vitamin D improves glycemia in T2D have shown conflicting results, subgroup and meta-analyses support the idea that raising serum vitamin D levels may reduce the progression from prediabetes to T2D.
In this review, we summarize current knowledge on the molecular mechanisms of vitamin D in insulin secretion, insulin sensitivity, and immunity, as well as the observational and interventional human studies investigating the use of vitamin D as a treatment for diabetes.
Download the PDF from VitaminDWiki
Risk of 44+ diseases at least double with poor Vitamin D Receptor
81+ Vitamin D Receptor pages in VitaminDWiki have CANCER in title
14 ways Vitamin D Receptor activation can be increased
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators
VitaminDWiki - The Vitamin D Receptor is associated with many health problems contains
Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (14 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (15 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies), Click here for detailsSome health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
VitaminDWiki - 24 studies in both categories Diabetes and Vitamin D Receptor
This list is automatically updated
- T2 Diabetes might be fought by Vitamin D plus Vitamin D Receptor activators – April 2023
- Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023
- T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020
- Diabetes decreased by activating Vitamin D Receptor (transgenic mice) – Feb 2020
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Diabetic nephropathy deactivates the Vitamin D Receptor, reducing tissue Vit D – Feb 2019
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Diabetic foot ulcer 1.7 times more likely if poor Vitamin D Receptor – Jan 2017
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Diabetes (T2) 16 percent more likely if Vitamin D receptor problem – Oct 2015
- Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
6 Reasons that medical professionals do not prescribe Vitamin D for Diabetes
- No profit for Big Pharma
Diabetes - A Lucrative Disease April 2023 - Less income for doctors or hospitals if stop diabetes
- The Vitamin D dose needed often varies by 4X between individuals for many health problems
Doctors prefer using a single dose of a drug for all patients - Doctors are unaware that small doses of vitamin D gut-friendly can be used
Gut-Friendly Vitamin D is available on Amazon, but not in pharmacies, nor by prescription
they are uncomfortable prescribing 4,000+ IU of vitamin D
in many countries, doctors can only prescribe D2 (which does not work as well), not D3 - Doctors are unaware that adding Magnesium helps prevent/treat Diabetes
they often just want to use a monotherapy - Doctors are unaware that sometimes the Vitamin D Receptors also need to be activated