Blood clotting (Thrombosis) and low Vitamin D - many studies

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More blood clotting (thrombosis) is associated with lower vitamin D – Dec 2024

Recent Updates and Advances in the Association Between Vitamin D Deficiency and Risk of Thrombotic Disease
Nutrients 2025,17,90. https://doi.org/10.3390/ nu17010090
Amirhossein Faghih Ojaroodi1, Fatemeh Jafarnezhad 2, Zahra Eskandari3, Shayan Keramat4,5 and Agata Stanek 4 *

1. Tabriz 5166616471, Iran; amirfaghih1103 at gmail.com
2. Department of Hematology, Faculty of Medicine, Ferdowsi University of Mashhad, Mashhad 9177899191, Iran; fatemeh.jafarnejad1995 at gmail.com
3. Department of Hematology, Faculty of Allied Medicine, Bushehr University of Medical Sciences,Bushehr 7518759577, Iran; zhraaeskndrii at gmail.com
4. VAS-European Independent Foundation in Angiology/Vascular Medicine, Via GB Grassi 74,20157 Milan, Italy; shayan.sk1993 at gmail.com
5. Support Association of Patients of Buerger's Disease, Buerger's Disease NGO, Mashhad 9183785195, Iran
6. Department of Internal Medicine, Metabolic Diseases and Angiology, Faculty of Health Sciences in Katowice, Medical University of Silesia, Ziolowa 45/47, 40-635 Katowice, Poland

Vitamin D (VD) is a vital lipophilic secosteroid hormone known for its essential role in maintaining skeletal health and regulating calcium and phosphate metabolism. Recent evidence has begun to illuminate its significance beyond bone health, particularly in relation to thrombosis—a condition characterized by blood clot formation within the vascular system that can lead to serious cardiovascular events such as myocardial infarction and stroke. VD deficiency, defined as a plasma 25-hydroxyVD level below 25 nmol/L, affects a substantial portion of the global population, with prevalence rates ranging from 8% to 18%. This study systematically explores the relationships between VD levels and the risk of thrombosis, investigating the underlying mechanisms including VD's anticoagulant properties, influence on inflammatory pathways, and interactions with endothelial cells. Epidemiological data suggest that low serum levels of VD correlate with an increased risk of venous thromboembolism (VTE), although the reported findings remain incon­sistent.
Mechanisms that potentially link VD to thrombotic risk include modulation of thrombomodulin and tissue factor expression, as well as enhancement of anti-inflammatory cytokines. Given the prevalence of VD insufficiency, particularly among populations with limited exposure to sunlight, this research highlights the urgent need for strategies to increase VD levels through dietary modifications and supplementation in order to prevent thrombotic events.
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Vitamin D and Its Relationship with the Pathways Related to Thrombosis and Various Diseases - chapter in book 2024?

Syed Mohd, Swati Sharma, Aastha Mishra and Mohammad Zahid Ashraf
Google Books

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Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis – Oct 2019

by Syed Mohammad, Aastha Mishra and Mohammad Zahid Ashraf *
Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, 110025, India
Biomolecules 2019, 9(11), 649; https://doi.org/10.3390/biom9110649 (registering DOI)
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Vitamin D, besides having an essential role in calcium and bone metabolism, also acts as a mediator of many non-calcemic effects through modulations of several biological responses. Vitamin D exists in its two major forms, vitamin D2, or commonly known as ergocalciferol, and vitamin D3, or commonly known as cholecalciferol. Both of these forms bind to vitamin D-binding protein to get transported to all vital target organs, where it serves as a natural ligand to vitamin D receptors for enabling their biological actions. Clinical reports corroborating vitamin D deficiency with an increase in thrombotic episodes implicate the role of vitamin D and its associated molecule in the regulation of thrombosis-related pathways. Thrombosis is the formation and propagation of a blood clot, known as thrombus. It can occur either in the arterial or the venous system resulting in many severe complications, including myocardial infarction, stroke, ischemia, and venous thromboembolism. Vitamin D, directly or indirectly, controls the expression of several genes responsible for the regulation of cellular proliferation, differentiation, apoptosis, and angiogenesis. All of these are the processes of potential relevance to thrombotic disorders. This review, thus, discussed the effects of vitamin D on pathways involved in thrombosis, such as hemostatic process, inflammatory pathway, and endothelial cell activation, with a focus on the molecular mechanisms associated with them.

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A few references from 2019 study

• Targher, G.; Pichiri, I.; Lippi, G. Vitamin D, thrombosis, and hemostasis: more than skin deep. Semin. Thromb. Hemost. 2012, 38, 114-124.
• Khademvatani, K.; Seyyed-Mohammadzad, M.H.; Akbari, M.; Rezaei, Y.; Eskandari, R.; Rostamzadeh, A. The relationship between vitamin D status and idiopathic lower-extremity deep vein thrombosis. Int. J. Gen. Med. 2014, 7, 303-309.
• Wu, W.X.; He, D.R., Low Vitamin D Levels Are Associated With the Development of Deep Venous Thromboembolic Events in Patients With Ischemic Stroke. Clin. Appl. Thromb. Hemost. 2018, 24, 69S-75S.
• Blondon, M.; Rodabough, R.J.; Budrys, N.; Johnson, K.C.; Berger, J.S.; Shikany, J.M.; Raiesdana, A.; Heckbert, S.R.; Manson, J.E.; LaCroix, A.Z.; Siscovick, D. The effect of calcium plus vitamin D supplementation on the risk of venous thromboembolism. Thromb. Haemost. 2015, 113, 999-1009.
• Topaloglu, O.; Arslan, M.S.; Karakose, M.; Ucan, B.; Ginis, Z.; Cakir, E.; Akkaymak, E.T.; Sahin, M.; Ozbek, M.; Cakal, E.; Delibasi, T. Is there any association between thrombosis and tissue factor pathway inhibitor levels in patients with vitamin D deficiency? Clin. Appl. Thromb. Hemost. 2015, 21, 428-433.
• Al Mheid, I.; Patel, R.; Murrow, J.; Morris, A.; Rahman, A.; Fike, L.; Kavtaradze, N.; Uphoff, I.; Hooper, C.; Tangpricha, V.; Alexander, R.W.; Brigham, K.; Quyyumi, A.A. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J. Am. Coll. Cardiol. 2011, 58, 186-192.
• Lindqvist, P.G.; Epstein, E.; Olsson, H. Does an active sun exposure habit lower the risk of venous thrombotic events? A D-lightful hypothesis. J. Thromb. Haemost. 2009, 7, 605-610.
• Brot, C.; Vestergaard, P.; Kolthoff, N.; Gram, J.; Hermann, A.P.; Sorensen, O.H. Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone. Br. J. Nutr.2001, 86, S97-103.

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Reduced clotting after 300,000 IU Vitamin D loading dose - Oct 2019

Thrombin generation and fibrin clot structure after vitamin D supplementation - Oct 2019
Endogenous thrombin potential and thrombin generation peak values both decreased significantly:-95.4nM*min to -15.1nM*min
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Low vitamin d is associated with thrombosis in systemic lupus erythematosus - 2018

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The relationship between vitamin D status and idiopathic lower-extremity deep vein thrombosis - June 2014

Int J Gen Med. 2014 Jun 19;7:303-9. doi: 10.2147/IJGM.S64812. eCollection 2014.
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12+ VitaminDWiki pages have THROMB OR CLOTTING in the title

The list is automatically updated

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