Those with Asthma or COPD had half the response to Vitamin D – March 2020

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Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease

Am J Respir Crit Care Med. 2020 Mar 18, DOI: 10.1164/rccm.201909-1867OC
David A Jolliffe 1, Christos Stefanidis 1, Zhican Wang 2, Nazanin Z Kermani 3, Vassil Dimitrov 4, John H White 5, John E McDonough 6, Wim Janssens 7, Paul Pfeffer 8, Christopher J Griffiths 9, Andrew Bush 10, Yike Guo 3, Stephanie Christenson 11, Ian M Adcock 12, Kian Fan Chung 13, Kenneth E Thummel 2, Adrian R Martineau 14

 Download the PDF from Sci-Hub via VitaminDWiki

Rationale: Vitamin D deficiency is common in patients with asthma and COPD. Low 25-hydroxyvitamin D (25[OH]D) levels may represent a cause or a consequence of these conditions.

Objective: To determine whether vitamin D metabolism is altered in asthma or COPD.

Methods: We conducted a longitudinal study in 186 adults to determine whether the 25(OH)D response to six oral doses of 3 mg vitamin D3, administered over one year, differed between those with asthma or COPD vs. controls. Serum concentrations of vitamin D3, 25(OH)D3 and 1α,25-dihydroxyvitamin D3 (1α,25[OH]2D3) were determined pre- and post-supplementation in 93 adults with asthma, COPD or neither condition, and metabolite-to-parent compound molar ratios were compared between groups to estimate hydroxylase activity. Additionally, we analyzed fourteen datasets to compare expression of 1α,25[OH]2D3-inducible gene expression signatures in clinical samples taken from adults with asthma or COPD vs. controls.

Measurements and main results:
The mean post-supplementation 25(OH)D increase in participants with

• asthma (20.9 nmol/L) and
• COPD (21.5 nmol/L) was lower than in
• controls (39.8 nmol/L; P=0.001).

Compared with controls, patients with asthma and COPD had lower molar ratios of 25(OH)D3-to-vitamin D3 and higher molar ratios of 1α,25(OH)2D3-to-25(OH)D3 both pre- and post-supplementation (P≤0.005). Inter-group differences in 1α,25[OH]2D3-inducible gene expression signatures were modest and variable where statistically significant.

Conclusions: Attenuation of the 25(OH)D response to vitamin D supplementation in asthma and COPD associated with reduced molar ratios of 25(OH)D3-to-vitamin D3 and increased molar ratios of 1α,25(OH)2D3-to-25(OH)D3 in serum, suggesting that vitamin D metabolism is dysregulated in these conditions.

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4 studies of Asthma and gut (Bifidobacterium infantis 35,624 helps - it is on Amazon)

The Role of the Microbiome in Asthma: The Gut–Lung Axis - Dec 2018
Int J Mol Sci. 2019 Jan; 20(1): 123 online 2018 Dec 30. doi: 10.3390/ijms20010123 FREE PDF
Franco Frati,1 Cristina Salvatori,1 Cristoforo Incorvaia,2 Alessandro Bellucci,1 Giuseppe Di Cara,1 Francesco Marcucci,1 and Susanna Esposito1,*

Asthma is one of the most common chronic respiratory diseases worldwide. It affects all ages but frequently begins in childhood. Initiation and exacerbations may depend on individual susceptibility, viral infections, allergen exposure, tobacco smoke exposure, and outdoor air pollution. The aim of this review was to analyze the role of the gut–lung axis in asthma development, considering all asthma phenotypes, and to evaluate whether microbe-based therapies may be used for asthma prevention. Several studies have confirmed the role of microbiota in the regulation of immune function and the development of atopy and asthma. These clinical conditions have apparent roots in an insufficiency of early life exposure to the diverse environmental microbiota necessary to ensure colonization of the gastrointestinal and/or respiratory tracts. Commensal microbes are necessary for the induction of a balanced, tolerogenic immune system. The identification of commensal bacteria in both the gastroenteric and respiratory tracts could be an innovative and important issue. In conclusion, the function of microbiota in healthy immune response is generally acknowledged, and gut dysbacteriosis might result in chronic inflammatory respiratory disorders, particularly asthma. Further investigations are needed to improve our understanding of the role of the microbiome in inflammation and its influence on important risk factors for asthma, including tobacco smoke and host genetic features.

Probiotics in Children with Asthma - July 2019
Children (Basel). 2022 Jul; 9(7): 978. doi: 10.3390/children9070978 FREE PDF
Giorgio Ciprandi1,* and Maria Angela Tosca2
Pierluigi Marzuillo, Academic Editor, Ming Lim, Academic Editor, Stefano Guarino, Academic Editor, Anna Di Sessa,

A type-2 immune response usually sustains wheezing and asthma in children. In addition, dysbiosis of digestive and respiratory tracts is detectable in patients with wheezing and asthma. Probiotics may rebalance immune response, repair dysbiosis, and mitigate airway inflammation. As a result, probiotics may prevent asthma and wheezing relapse. There is evidence that some probiotic strains may improve asthma outcomes in children. In this context, the PROPAM study provided evidence that two specific strains significantly prevented asthma exacerbations and wheezing episodes. Therefore, oral probiotics could be used as add-on asthma therapy in managing children with asthma, but the choice should be based on documented evidence.

Probiotics in asthma management: fiction or truth? - March 2023
Expert Review of Clinical Immunology Volume 19, 2023 - Issue 5 https://doi.org/10.1080/1744666X.2023.2189103 FREE PDF
Giorgio CiprandiORCID Icon,Maria Angela Tosca &Lorenzo Drago
"Very recently, Bifidobacterium infantis 35,624 has been positively tested in asthmatic adults [16]. This study provided interesting results, as evidenced that this probiotic significantly improved asthma control in the subgroup of patients with initial uncontrolled asthma."

Asthma associated with Reflux - Sept 2022
RubaHealth

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Breathing category

455 items in Breathing category

Breathing-related Overviews at VitaminDWiki:
Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu
Pneumonia   Respiratory infections   COPD   Air Polution   Smoking   Cystic Fibrosis

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Overview Asthma and Vitamin D contains

• VitaminDWiki pages containing ASTHMA in title (164 as of Nov 2024)
• Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
  • Started with 100,000 IU loading dose and has standard-of-care Asthma drug
• Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
• Those with Asthma or COPD had half the response to Vitamin D – March 2020
  • Those with Asthma need larger doses to get the same response.
  • Probably need gut-friendly Vitamin D
• CDC funded study: 1.3 X Asthma risk if vaccination contained aluminum – Sept 2022
• Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
• Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
• Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
• Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
• 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
  • CDC list of high-risk for COVID-19 includes Asthma
• Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
• Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
• Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
• Proof that Vitamin D Works 92 health problems prevented/treated as of Nov 2020
  • Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
• Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
• Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
• Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
• If high vitamin D during pregnancy the child is 5X less likely to get asthma
• Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
• Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
• The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart

click on the chart to see the study

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13 Items in both categories Breathing and non-daily intervention

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VitaminDWiki – COPD fought by Vitamin D - many studies contains:

• Vitamin D is one of the alternate COPD therapies – March 2021
• COPD treated by Vitamin D – meta-analysis March 2022
• COPD quality of life improved by 400,000 IU Vitamin D loading dose – RCT July 2019
• COPD exacerbations 2X less often if low vitamin D then supplemented – meta-analysis Jan 2019
• Worse breathing with COPD is related to lower Vitamin D – June 2018
• COPD ICU stay is 2.4 days longer if low vitamin D – Oct 2015
• COPD and Vitamin D, concise (46 page) review – Dec 2016
• 100000 IU vitamin D monthly helps COPD patients – 3 RCT
• Those with Asthma or COPD had half the response to Vitamin D – March 2020

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Study was cited 78 times as of Jan 2024

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