The effects of Vitamin D on acute viral respiratory infections: a rapid review - Aug 2020
Ryan Bradley bradley at nunm.edu 1, Janet Schloss* 3,4, Danielle Brown' Deisy Celis2/ John Finnell' Rita Hedol Vladyslav Honcharov2/ Traci Pantuso' Hilda Pena2, Romy Lauche3' Amie Steel3 1Helfg Ott Research Institute,
Clinical significance:
Despite several positive systematic reviews and meta-analyses, the available experimental evidence related to the effects of vitamin D on acute respiratory tract infection (ARTI) is plagued with heterogeneity and mixed quality, and therefore is insufficient to recommend vitamin D supplementation to the general population as a protective agent against ARTI. However, based on the evidence identified in this rapid review (including a high margin of clinical safety), combined with strong mechanistic rationale, the following recommendations can be made for those at risk of ARTI:
- 1. vitamin D status should be tested for those at risk of ARTI;
- 2. patients identified with deficiency or insufficiency should be supplemented with vitamin D until their status is normalized; and
- 3. daily dosing of vitamin D3 is preferred to achieve serum concentrations > 30 nmol/L in a timely manner.
Clinical trials support vitamin D doses of 800 IU/day up to 10,000 lU/day with 1,000 - 2,000 lU/day being a common dosing strategy in clinical trials, and potentially more effective then lower daily or bolus dosing strategies.
VitaminDWiki comments on study
Download the PDF from VitaminDWiki
Huge range of amount of Vitamin D given: as low as 40 IU
- Sorry, unable to extract text from this PDF without lots of errors
- Perhaps the watermark was too intense
- PDF is extremely conservative: the goal of >13 ng
- Most health studies conclude that people need > 30ng,
- Some studies conclude that the goal should be > 50 ng
- They incorrectly assume that the common dosing strategy is a good dosing strategy
- This study, like many previous studies, found that a single large (bolus) dose when not followed up with maintenance dosing, does not help.
Respiratory Tract Infection risk reduced 2X by Vitamin D loading doses – meta-analysis Jan 2021
Items in both categories Breathing and Virus are listed here:
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- Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
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- Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis Jan 2022
- Italians entering hospital for breathing problems had low vitamin D (with and without COVID), Vitamin D should help – Nov 2021
- Superspreaders appear to have viscous lung fluids or be obese
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020
- COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020
- Respiratory viral infection (RSV) and low vitamin D - many studies
- Zinc, respiratory tract infections and COVID-19 – July 2020
- Vitamin D reduces viral respiratory infections – editorial April 18, 2020
- Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019
- Ultraviolet light kills cold and flu viruses, and generates Vitamin D in the skin
- Respiratory Virus risk reduced 35 percent by Vitamin D (14,000 IU weekly) – RCT Oct 2018
- Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Loss of smell may be related to low Zinc or perhaps low vitamin D
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Immune response to respiratory viruses – vitamin D connection – review May 2015
- Overview Colds and flu and Vitamin D
- Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010
Breathing category starts with the following
Breathing-related Overviews at VitaminDWiki:
Allergy Lung Cancer TB Asthma Influenza Colds and flu
Pneumonia Respiratory infections COPD Air Polution Smoking Cystic Fibrosis
Breathing items with ACUTE in title
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