400 IU of vitamin D does not prevent fractures – US Preventive Services – April 2018

Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults

US Preventive Services Task Force Evidence Report, April 17, 2018
Evidence Report and Systematic Review for the US Preventive Services Task Force
Leila C. Kahwati, MD, MPH1,2; Rachel Palmieri Weber, PhD1,3; Huiling Pan, BA1,2; et al Margaret Gourlay, MD, MPH1,4; Erin LeBlanc, MD, MPH5; Manny Coker-Schwimmer, MPH1,3; Meera Viswanathan, PhD1,2

They narrowed the analysis of Vitamin D in preventing fractures to just 4 studies

1 study used 300 IU – far too little
1 study used 400 IU – far too little
1 study used 100,000 IU every 3 months (both too little and too infrequent)
1 study used 100,000 IU monthly – the only study which had the possibility of reducing fractures

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I could not understand why JAMA continues to publish such trash. - Henry Lahore, founder of VitaminDWiki
Perhaps they want to save Osteoporosis jobs
They do not want to experience the job loss which occured in Australia 5 years before - see the following

• 20X increase in vitamin D sold and 36 percent decrease in osteoporosis business in Australia – Nov 2013

See also VitaminDWiki

• Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017
• Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014

Falls and Fractures category contains the following summary

• 258 items in FALLS and FRACTURES
• Vitamin D and Calcium cost-effectively reduce falls and fractures – April 2019
• see also Overview Seniors and Vitamin D
  • Overview Fractures and Falls and Vitamin D
  • Overview Fractures and vitamin D
  • Muscles and Vitamin D - many studies

Falls

• Fall prevention - Vitamin D is one of the ways - umbrella review Jan 2024
• Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019
• Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
• Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
• Falls reduced by a third if achieved 40 ng level vitamin D– RCT Sept 2018
  • Note: It took 6 months to get to that level. Most trials last only 3 months
• Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
• Falls reduced by Vitamin D: 13 percent reduction if more than 700 IU – review of 38 trials – Aug 2022

Left hand column section as of Nov 2024

Fracture

• Hip fractures are predicted by 10 factors – low Vitamin D is the biggest – Aug 2023
• Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
• Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
• Vitamin K (any amount and any kind) reduced bone fractures by 24 percent – meta-analysis – May 2019
• 77+ Hip fracture items in VitaminDWiki title   Click here for details examples:
  • Risk of Hip fracture cut in half if Vitamin D was prescribed - Aug 2023
  • Call to action: Vitamin D to prevent of treat hip fracture (50,000 weekly for 8 weeks, then bi-weekly) – Holick July 2020