Neuropathy treated by vitamin D - many studies

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15+ VitaminDWiki titles contain NEUROPATHY

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Diabetic Neuropathy treated by 5,000 IU of Vitamin D daily (more than 8 weeks would be far better) - RCT Dec 2021

The Benefits of Add-on Therapy of Vitamin D 5000 IU to the Vitamin D Levels and Symptoms in Diabetic Neuropathy Patients: A Randomized Clinical Trial
Rizaldy Taslim Pinzon,Vincent Ongko Wijaya &Vanessa Veronica
Journal of Pain Research Pages 3865-3875

Background
Previous studies have demonstrated a significant relationship between vitamin D deficiency and the development of diabetic peripheral neuropathy (DPN). However, current studies are limited regarding the potential therapeutic benefits of vitamin D therapy in these patients.

Objective
This study aimed to assess the effect of oral vitamin D supplementation in patients with diabetic peripheral neuropathy in addition to standard treatment.

Methods
This study was a controlled, open-label, randomized clinical trial with an active comparator randomly allocated with a 1:1 ratio. The experimental group received an add-on oral vitamin D 5000 IU once daily and standard treatment (pregabalin, gabapentin, or amitriptyline) over eight weeks. The control group received standard treatment alone. The measured outcomes were the change in the score of the visual analog scale (VAS), numerical rating scale (NRS), and brief pain inventory (BPI). Vitamin D levels were also measured before and after the trial.

Results
Data from 68 subjects with DPN was collected and analyzed. Most of them (60.3%) were female, aged 64.96 ± 8.3 years. After eight weeks of treatment, the experimental group showed a

• more significant reduction of mean VAS (−3.34 ± 2.03 vs −2.37 ± 2.2, p=0.044) and
• burning pain (1.76 ± 7.16 vs 6.18 ± 13.93, p=0.046)

scores compared to controls. Mood also improves better in the experimental group (88.2% vs 70.6%, p=0.031). At the end of the study, vitamin D levels were also improved more significantly in the experimental group (40.02 ± 15.33 ng/mL vs 18.73 ± 6.88 ng/mL; p<0.001) with greater changes from the baseline to week 8 (+24.14±13.68 ng/mL vs +3.10±4.20 ng/mL; p<0.001) compared to control group. The intervention group showed a negative correlation between vitamin D level and VAS score (r = −0.403, P = 0.018). There were no adverse events recorded in this study.

Conclusion
The addition of oral vitamin D 5000 IU to standard treatment significantly improves pain, mood, and vitamin D levels more effectively than standard treatment alone in patients with diabetic neuropathy.
 Download the PDF from VitaminDWiki
Typically 5,000 IU of Vitamin D takes 5+ months to platue

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Complementary and Alternative Medicine for Painful Peripheral Neuropathy - 2019

Curr Treat Options Neurol. 2019 Sep 2;21(9):44. doi: 10.1007/s11940-019-0584-z.
Baute V1, Zelnik D2,3, Curtis J2, Sadeghifar F2.
1 Dept of Neurology, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston Salem, NC, 27157, USA. vbaute at wakehealth.edu.
2 Dept of Neurology, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston Salem, NC, 27157, USA.
3 Integrative Medicine Center, Concentra, 1500 W I-240 Service Rd, Oklahoma City, OK, 73159, USA.

PURPOSE OF REVIEW:
The purpose of our manuscript is to review the current evidence supporting the use of complementary and alternative medicine (CAM) in neuromuscular disease, specifically in painful peripheral neuropathy (PPN). We outline the therapeutic challenges of this debilitating condition and describe the best evidence for incorporating such therapies into clinical practice. The most studied modalities include lifestyle modifications with diet and exercise, supplements, and acupuncture. CAM therapies such as yoga, meditation, electrical stimulation, neuromodulatory devices, and cannabis are mentioned as emerging therapies.

RECENT FINDINGS:
Current data suggests that targeted lifestyle modifications, including aerobic exercise and diet modifications that promote weight loss, may improve the natural course of diabetic painful neuropathy and potentially other types of neuropathy. A number of studied dietary supplements and vitamins including B vitamins, vitamin D, alpha-lipoic acid, and acetyl-L-carnitine improve both subjective and objective neuropathic measures. A wide range of neuromodulatory devices and electrical stimulation modalities demonstrate mixed results, and further studies are needed to confirm their benefit. Finally, acupuncture and yoga both demonstrate benefit in a variety of PPNs. Multiple CAM therapies show efficacy in the treatment of PPN. From the strongest level of evidence to the least,

• lifestyle modifications including exercise and diet;
• supplements including B12, alpha lipoic acid, acetyl-L-carnitine, and vitamin D in deficient patients; followed by
• acupuncture and yoga may alleviate symptoms of PPN.

Clipped from the PDF

Vitamin D
…prospective study in 51 patients with painful DPN and vitamin D insufficiency showed that 2000 IU of cholecalciferol (vitamin D3) daily for 3 months resulted in a 50% decrease in the visual analog pain score [33]. A placebo-controlled study in patients with DPN and vitamin D deficiency randomized to 50,000 IU of vitamin D3 once weekly for 8 weeks showed improvement in the Neuropathy Disability Score [34]. Another study of painful DPN found that a single IM dose of 600,000 IU of vitamin D3 had a significant effect on reducing neuropathic pain symptoms and pain scores [35]. This therapeutic effect was maximal at 10 weeks, lasted the 20-week study period, and was independent of baseline vitamin D levels. Further studies are warranted to examine the use of vitamin D3 in those with normal serum vitamin D levels and to employ the use of objective measurements such as nerve conduction studies.

THC, CBD
Cannabis (marijuana) for medicinal use has become popular in recent years (currently legal in some form in 32 US states). Aside from cumbersome prescribing issues, the lack of clear safety and quality standards for treatment with cannabis makes many clinicians give pause to this treatment for PPN (despite patients wholeheartedly embracing it). The following section summarizes the evidence for the use of supplements and cannabinoids in the treatment of PPN.

Currently, the endocannabinoid system is being investigated for its role in the modulation of neuropathic pain. Understanding this pathway is an emerging area in the development of new pharmaceutical drugs to treat refractory PPN. Meanwhile, medicinal cannabis (i.e., medical marijuana) and its main chemical components tetrahydrocannabinol (THC) and cannabidiol (CBD) are currently available (where legal) and becoming popular for self-management of refractory chronic pain syndromes. THC is the component responsible for psychoactive symptoms but also with what appears to be dose-dependent analgesic effects [48, 49, 50]. CBD is not psychoactive and has anti-inflammatory and antioxidant properties. Potential THC side effects of cognitive impairment and psychosis, among others, raise concerns regarding the safety and tolerability of high-dose THC preparations for treatment of refractory PPN. There are a small number of studies investigating different formulations of cannabis, including various THC concentrations in smoked whole plant, isolated THC+CBD, plant- derived THC, and synthetic THC. These studies suggest that patients can benefit from cannabis for neuropathic pain relief, however for now, that is still accompanied by expected dose-dependent side effects (largely psychiatric) [48, 49, 50].

Magnesium
It has been observed that almost 25% of type 1 diabetic patients with or without DPN have low levels of circulating magnesium [36]. In type 2 diabetes patients, neuropathy was found to be more prevalent when magnesium depletion was present, though a direct causal relationship is not clear [37]. Two studies have shown a correlation between low magnesium levels and abnormal nerve conduction study results [37, 38]. Long-term supplementation with 300 mg daily magnesium glycinate vs no supplementation for 5 years in type 1 diabetic patients restored a normal magnesium status and slowed down the natural progression of PN based on patient symptoms and neurologic exam [36]. Based on this preliminary information, more research investigating dosing, tolerability, and effectiveness of oral magnesium supplementation in patients with DPN will inform its clinical use.
 Download the PDF from Sci-Hub via VitaminDWiki

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Vitamin D not only fights PN and chronic pain but also prevents and treats Diabetes

Pain - chronic category contains

165 items in category Chronic pain

See also

• Overview Pain and Vitamin D
• Percentage of people with pain increased 25 percent in 18 years – Jan 2019
• Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
• Overview Fibromyalgia or Chronic Fatigue and vitamin D
• Overview Rheumatoid Arthritis and vitamin D
• Shingles and vitamin D
• Shin splints decrease with vitamin D
• Migraine and Vitamin D
• Headache category 82 items
• "musculoskeletal pain" 490 items as of Aug 2023
• "chronic fatigue" 185 items as of Jan 2017
• Category Back Pain 44 items
• 7 pain studies in VitaminDWiki with KNEE in the title as of Aug 2023 (see below)
• Opioid OR Opiate OR Morphine in the title 10 pages as of June 2021

Overview Diabetes and vitamin D contains

• Diabetes is 5X more frequent far from the equator
• Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
• Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
• Sedentary people get less sun / Vitamin D
• Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
• Elderly get 4X less vitamin D from the same amount of sun
      Elderly also spend less time outdoors and have more clothes on
• All items in category Diabetes and Vitamin D 551 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

• Appears that >2,000 IU will Prevent
• Appears that >4,000 IU will Treat , but not cure
• 90% less T2 Diabetes in the group having lots of Vitamin D
• Appears that Magnesium helps both Prevention and Treatment
• Many diabetics would be better treated if Gut-Friendly Vitamin D were used

Number of articles in both categories of Diabetes and:

• Dark Skin 24;   Intervention 56;   Meta-analysis 40;   Obesity 36;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 13;  Magnesium 29    Click here to see details

Some Diabetes studies

• Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024
• Diabetes and Vitamin D meta-analyses - many studies 39+ as of Nov 2024
• 99.7% of people who got Diabetes had been regularly consuming food emulsifiers - May 2024
• Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
• Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
• Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
• Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
• T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021

50 ng of Vitamin D fights Diabetes

• Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
• Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018

T1 Diabetes

• T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
• Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
• Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019

Pre-Diabetes

• 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
• Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
• Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020

Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetic Epidemic

• Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
  Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
  That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
  Chart from the web (2018?)
  

See clipped from the PDF at the bottom of thes page: Vitamin D, CBD, Magnesium

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29 Items in both categories Diabetes and Magnesium

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Google Scholar "Peripheral Neuropathy" "Vitamin D" 18,600 items March 2023

• A systematic review on the efficacy of vitamin D supplementation on diabetic peripheral neuropathy - Oct 2020 https://doi.org/10.1016/j.clnu.2020.01.022 behind paywall - All 4 studies found a benefit
• Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle-aged patients - April 2019 https://doi.org/10.1002/dmrr.3162 FREE PDF
• Effect of Low Level Laser Therapy on serum vitamin D and magnesium levels in patients with diabetic peripheral neuropathy – A pilot study - April 2019 on VitaminDWiki https://doi.org/10.1016/j.dsx.2019.01.022
• Dose vitamin D supplementations improve peripheral diabetic neuropathy? A before-after clinical trial - Jan 2019 https://doi.org/10.1016/j.dsx.2018.12.014 behind paywall
  • 50,000 IU weekly for 12 weeks helped (Note: probably have helped in 4 weeks if has started with a loading dose)
• High-Dose Vitamin D Supplementation Improves Microcirculation and Reduces Inflammation in Diabetic Neuropathy Patients - Aug 2020 https://doi.org/10.3390/nu12092518 FREE PDF

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Google Scholar "Peripheral Neuropathy" and "Vitamin B" 12,700 items March 2023

• A systematic review on the efficacy of vitamin B supplementation on diabetic peripheral neuropathy - May 2022 https://doi.org/10.1093/nutrit/nuab116 14 RCTS   PDF is behind paywall
• Vitamin B for treating diabetic peripheral neuropathy – A systematic review - Oct 2021 5 studess, uncertain results https://doi.org/10.1016/j.dsx.2021.102213 behind a paywall

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