see also Overview Diabetes and vitamin D Overview Metabolic Syndrome and vitamin D
Autoimmune category listing has
- 34+ VitaminDWiki pages with PREDIABETES or PREDIABETIC in title
- Prediabetics helped by Vitamin D - umbrella of 31 RCTs Aug 2025
- Diabetes increases the risk of other health problems
- VitaminDWiki Diabetes pages with NEUROPATHY in title (14 as of Aug 2022)
- VitaminDWiki Diabetes pages with INSULIN in title (xx as of Drpy 2025)
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564 Diabetes articles - All categories associated with Diabetes
- Type 1 Diabetes (most are adults)
34+ VitaminDWiki pages with PREDIABETES or PREDIABETIC in title
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Prediabetics helped by Vitamin D - umbrella of 31 RCTs Aug 2025
Effects of vitamin D supplementation on metabolic parameters, anthropometric measures, and diabetes risk in patients with prediabetes: an umbrella review of meta-analyses of randomized controlled trials
Nutrition & Metabolism (2025) 22:99 https://doi.org/10.1186/s12986-025-00994-1
Roghayeh Molani-Gol, Maryam Rafraf & Sara SafariNote the huge differences between meta-analyses in both dose and duration
Background
The prevalence of prediabetes and, consequently, type 2 diabetes is increasing around the world. Previous meta-analyses reported controversial findings regarding the association between vitamin D supplementation with glycemic control and diabetes risk. This comprehensive meta-analysis summarized existing research to provide an estimate of the impact of vitamin D supplementation on metabolic parameters and diabetes risk in individuals with prediabetes.Method
A comprehensive systematic search was conducted across the Web of Science, Scopus, PubMed, and Cochrane databases, and Google Scholar using relevant keywords until 22 July 2025. The AMSTAR2 scale was used to evaluate the methodological quality of the included articles. Moreover, the certainty of the evidence was assessed using the GRADE tool. Stata 17 software was used for data analysis.Results
Fourteen meta-analyses comprising 31 randomized controlled trials (RCTs) of 3856 prediabetic patients were included in this review. Combining the findings of RCTs revealed that vitamin D supplementation significantly reduced the levels of- fasting blood sugar (WMD= -0.377 mg/dl, 95% CI (-0.589, -0.165), p < 0.001),
- insulin (WMD = -0.174 µU/mL, 95% CI (-0.274, 0.074), p < 0.001),
- hemoglobin A1c (WMD = -0.479%, 95% CI (-0.714, -0.245), p < 0.001), and
- serum triglyceride (TG) (WMD = -0.385 mg/dl, 95% CI (-0.622, -0.147), p = 0.002)
+in comparison with the control group.
The effects of vitamin D on insulin resistance by homeostasis model assessment, 2-hour oral glucose tolerance test plasma glucose, homeostasis model assessment of β-cell function, body mass index, and diabetes risk of participants were not significant.
Conclusion
The findings of this umbrella review suggested that vitamin D supplementation could help to improve some glycemic indices and TG levels. However, due to discrepancies among the results, more well-designed RCTs are warranted to confirm and clarify the impacts of vitamin D supplementation in prediabetic patients.
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Diabetes increases the risk of other health problems
Diabetes leads to many diseases - need to restore the vitamin D levels
Diabetes ==> Cognitive impairment
Diabetes ==> Vertebral fracture in men only
Diabetes ==> Rheumatoid Arthritis
Diabetes ==> Pancreatic Cancer
Diabetes ==> Alzheimer's
Depression <==> Diabetes 2 way interaction
VitaminDWiki Diabetes pages with NEUROPATHY in title (14 as of Aug 2022)
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The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach - Jan 2020
VitaminDWiki Diabetes pages with INSULIN in title (xx as of Drpy 2025)
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564 Diabetes articles - wiki page:
- Prediabetes 7X more likely for Japanese women if low vitamin D - Sept 2025
- Top 10 health problems worse since COVID-19 - Aug 2025
- Higher risk of Hypertension, Diabetes, and Stroke if near large body of water (microplastics) - March 2025
- More than 50% increase per decade: asthma, obesity, diabetes, hypertension, cancer, etc. - 2025
- Type II Diabetics: Most common deficiency is Vitamin D (2nd is Magnesium) – meta-analysis Jan 2025
- Metformin appears to activate the Vitamin D Receptor (more D to kidney cells, etc,) - March 2025
- Gestational Diabetes Risk is increased 4.2 X if low Vitamin K2 MK-7 - Jan 2025
- Dark Skin Diabetics and Vitamin D - many studies
- Vitamin D, minerals (Mg, Ca, K, Phosphate, Na, Fe, Zn, Cl, Se) and health – 15 studies 2024
- Diabetics more likely to die if low Magnesium (MDS) - Jan 2025
- Type 1 Diabetic inflammation reduced by 50 ng of Vitamin D - Dec 2024
- Vitamin D Roles - more than just help the immune system
- Diabetes and Vitamin D meta-analyses - many studies
- Diabetes and Zinc - several studies
- Earthing reduces blood viscosity and helps diabetes - Oct 2024
- T2 Diabetes and associated CVD problems fought by Vitamin D (weekly 50,000 IU) – Sept 2024
- Type 2 Diabetes 2 X less likely if triple the vitamin D level (222,000 Danes) - Sept 2024
- Water-soluble form of vitamins are needed for some health problems
- Type 2 Diabetes and Vitamin D – Overview of 20 years of research – Aug 2024
- C15:0 (Fatty15, Pentadecanoic acid) a fatty acid from grass-fed animals may be essential - several studies
- Diabetics with low vitamin D had 1.4X more infections – Aug 2024
- DNA analysis of genes (Polygenic risk) shows increased risk of 9 health problems (all 9 fought by Vitamin D) – Feb 2024
- Retinopathy in males 6.9 X more likely if low vitamin D and low Magnesium - June 2024
- Magnesium Depletion Score predicts increased risk of various health problems
- 99.7% of people who got Diabetes had been regularly consuming food emulsifiers - May 2024
- Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024
- Vitamin D-A New Therapeutic Target in the Management of Type 2 Diabetes Patients – Feb 2024
- Risk of Type II Diabetes was cut if half if had a predicted 30 ng of vitamin D – March 2024
- Many T1 diabetics in Finland are self-treating with more than 1200 IU of Vitamin D daily – Feb 2024
- Gestational Diabetes best fought by Vitamin D plus probiotics – RCT review Dec 2023
- Off Topic: Xylitol reduces cavities, preterm births, osteoporosis, RTI, obesity, diabetes, etc. - several studies
- Men with 20 years of type 1 Diabetes have the same vitamin D levels as controls - Dec 2023
- T2 Diabetes is also fought by Vitamin K2 – several studies
- Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
- UV reduces cardiovascular and metabolic problems– Vitamin D plus Nitric oxide – Sept 2023
- Diabetes increases chance of death (low vitamin D) - many studies
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- FDA drug to TREAT child Type 2 diabetes (based on 1 trial of only 50) – June 2023
- Diabetes 30% more likely in those with low birth weight - June 2023
- Vitamin D both reduces CVD directly and reduces metabolic problems that cause CVD – May 2023
- 11 Diabetes problems are associated with low Vitamin D – review May 2023
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- T2 Diabetes might be fought by Vitamin D plus Vitamin D Receptor activators – April 2023
- Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023
- Type 2 diabetes attributable to suboptimal diet in 184 countries (note: Vit D, Mg help) – April 2023
- High fluoride in water: 5X more likely to be Vitamin D deficient – Jan 2023
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Active vitamin D is related to COVID and Diabetes in 15 ways – Dec 2022
- T1 Diabetic adults 5X more likely to get COVID (hint low vitamin D)– Nov 2022
- Depression more likely if low vitamin D (3.5 X prediabetic women in this case) – Oct 2022
- Red meat consumption increases risk of Diabetes - many studies
- T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- Autoimmune diseases fought by Vitamin D, especially if have more than 40 ng – Sept 2022
- Glycemic control of type 2 diabetes – only Vitamin D had high quality studies – meta-analysis Sept 2022
- Increased Phosphorus increases Vitamin D getting to cells (CYP24A1, pigs) - Aug 2022
- Gestational Diabetes Mellitus 10X more-likely if low vitamin D in first trimester – July 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- T1 Diabetes 6.5 X more likely in South African Blacks if poor Vitamin D Binding Protein – July 2022
- Non-alcoholic fatty liver disease: 75 percent of overweight adults and type II diabetics – Aug 2022
- Gestational Diabetes 2.1 X more likely if less than 30 ng of Vitamin D - July 2022
- Vitamin K2-7 helps bone, blood vessels, cancer, diabetes, etc. – June 2022
- Diabetics 5X more-likely to get CKD if have very low Vitamin D – June 2022
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Treating pre-diabetes with Magnesium Chloride should be cost effective – June 2022
- Reduced Magnesium is associated with reduced health (Diabetes in this case) - April 2022
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- A small amount of Vitamin D analog did not help diabetes - May 2022
- Diabetic Retinopathy associated with low Vitamin D - many studies
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Diabetic Neuropathy treated by Vitamin D – review April 2022
- Prediabetes in US youths increased 2X in 2 decades - March 2022
- Diabetes: 1 in 10 people have it, but half do not know it – Nov 2019
- Diabetes prevented by 50,000 IU vitamin D monthly (Iran) – Jan 2022
- Vitamin D separately helps X or COVID, should help X with COVID (example: diabetes) – March 2022
- Treadmill exercise helps (Diabetics in this case) - Jan 2022
- Dementia 1.7X higher risk if diabetic and low vitamin D - Jan 2022
- Vitamin D2 not help – again ( T1 diabetes– which has been helped by D3) – Jan 2022
- Diabetes - 1 in 10 adults, 966 billion dollar cost in 2021
- Most Diabetics getting 40,000 IU of vitamin D weekly did not get to 30 ng (needed gut-friendly form) - RCT June 2020
- Vitamin D might a risk factor of insulin resistance, diabetes, obesity, etc. (50 ng) – Oct 2021
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- Vitamin D given for 6 weeks did not slow prediabetes progression 2 years later (no surprise) – RCT Aug 2021
- Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
- Insulin Resistance is associated with low Vitamin D (both diabetic and non-diabetic) – meta-analysis May 2021
- Diabetic Neuropathy 2.8X higher risk if low vitamin D – meta-analysis May 2021
- Risk of diabetes greatly reduced by sardines (suspect Omega-3) – May 2021
- COVID-19 hospitalizations: 63% associated with diabetes, obesity, hypertension or heart failure – Feb 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
- Diabetes has many bidirectional links with COVID-19 – March 2021
- Off topic: In 1854 a medical journal proposed that Diabetes would be treated by Brewer’s Yeast
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Somewhat less Type 1 Diabetes in Wales recently – perhaps more sun or more vitamin D – March 2021
- Little Vitamin D benefit if not achieve a good level (T1D in this cases) – Jan 2021
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Endocrine Disrupting Chemicals and Vitamin D (T1 Diabetes in this case) - April 2020
- Elderly diabetic problems are associated with low vitamin D and often treated as well – 34 study review Feb 2021
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Low bone mineral density is inversely associated with both Vitamin D and Resistin (resistance to insulin)
- Increased risk of diabetes if have poor Vitamin D genes – Dec 2020
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020
- Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020
- How Vitamin D prevents Hyperglycemia – Sept 2020
- Hyperglycemic 2X more likely to have severe COVID-19 - Nov 2020
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Vitamin D deficiency associated with increased risk of many health problems in 58,000,000 Americans - Nov 2020
- Diabetics with high vitamin D have 40 pcnt less all-cause mortality – Nov 2020
- Diabetes increases COVID-19 severity and COVID-19 creates Diabetes - Oct 2020
- How Vitamin D prevents Insulin Resistance – Sept 2020
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- Diabetes and poor Vitamin D genes - many studies
- COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
- Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018
- Diabetes not helped by increasing Vitamin D levels to 20 ng (proven again) – RCT March 2020
- Live 7 years longer free of major disease if eat well, not smoke, not obese, moderate drink and exercise (100,000 people) – Jan 2020
- Diabetes decreased by activating Vitamin D Receptor (transgenic mice) – Feb 2020
- Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020
- US young adults – 24 percent have prediabetes (many low-cost ways to treat)– Jan 2020
- Prediabetics had different gut bacteria – April 2018
- Diabetes helped by 5,000 IU of Vitamin D – RCT Sept 2019
- Pre-diabetics with low vitamin D are more likely to become diabetic – May 2019
- How Vitamin D both prevents and treats insulin resistance (Diabetes) – April 2019
- Restless Legs Syndrome has increased risk with diabetes – many studies
- Diabetes, immune system and Vitamin D – book chapter – 2019
- 100,000 IU of Vitamin D3 monthly for 4 months to diabetics (D2 bombed) – RCT Dec 2019
- Poor Tuberculosis outcomes if low vitamin D and diabetic – Dec 2019
- Diabetic nerve damage (Polyneuropathy) was 2.7 X more likely if low vitamin D, etc. – Dec 2019
- The worse the diabetic foot, the lower the vitamin D level – Nov 2019
- Milk Consumption Is strongly linked to Type 1 Diabetes – Dr. Greger Nov 2019
- Fasting and Diabetes both reduce Vitamin D activation (CYP2R1 in rodents) – May 2019
- Most Diabetics helped by Vitamin D (90 percent are deficient) – Nov 2019
- Diabetes increases risk of poor cognition by 2X, 12 weeks of Vitamin D not help (but 18 weeks did) – RCT Oct 2019
- T1 Diabetes treated by Vitamin D and Omega-3 - Jan 2018
- Children in India – 1 in 7 extremely low Vitamin D, 1 in 10 prediabetic – Sept 2019
- Half of Diabetics cured in 16 days by eating a plant-based diet – Dr. Greger Sept 2019
- Type II diabetes 2 X more likely if poor Vitamin D Gene (CYP27B1) – Oct 2019
- 90 percent remission of recently diagnosed diabetes with a low-calorie diet
- Type 1 diabetes trial having problems getting participants – too many taking Vitamin D or Omega-3 – Aug 2019
- Diabetes and pre-diabetes helped by Vitamin K in animal studies – review Oct 2019
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- T1 Diabetes reduction by high Omega-3 and Vitamin D – GRH ongoing observation
- Neuropathy treated by vitamin D - many studies
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Diabetics and prediabetics helped by 5,000 IU of Vitamin D for 6 months– RCT July 2019
- Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014
- Depression reduced in Diabetics with 3 months of 4,000 IU of vitamin D – RCT July 2019
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019
- Deep wounds (Diabetic) healed slowly if low vitamin D – June 2019
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Diabetic kidney problems in children last longer if low vitamin D – May 2019
- Vitamin D fails to prevent Type 2 Diabetes (unaware of 8 proven ways) June 2019
- Diabetics (with metformin) were 8X more likely to have low vitamin D than healthy controls – May 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Women with diabetes 60 percent more likely to get Cancer (perhaps low vitamin D) – May 2019
- Death by Sugar
- Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
- Vitamin D helps Diabetic Nephropathy kidneys – meta-analysis April 2019
- Better lipid and diabetic profiles if higher level of vitamin D – March 2019
- Insulin prices and usage are soaring
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Excess Uric Acid associated with low vitamin D
- Infertile women 10 percent more likely to die (perhaps due disease associated with low vitamin D – Nov 2017
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Diabetic Foot Ulcers helped by Vitamin D - meta-analyses many studies
- Vitamin D prevents diabetes but Dairy does not appear to help – March 2019
- Diabetic nephropathy deactivates the Vitamin D Receptor, reducing tissue Vit D – Feb 2019
- Prediabetes both prevented and treated by monthly Vitamin D, etc.
- Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019
- Insulin problems reduced by Curcumin if not also take Omega-3 – RCT Jan 2019
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
- Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D – Jan 2019
- T1 Diabetes – how it may be prevented and treated by Vitamin D – Dec 2018
- Vitamin D and Omega-3 may treat Type 1 Diabetes – RCT 2024
- Raising vitamin D levels shown to prevent 80% of type 2 diabetes cases - Oct 2018
- Depression twice as common in Diabetics (both have low vitamin D) – Aug 2018
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Periodontitis with low Vitamin D increases risk of Diabetes by 2.8 X – July 2018
- Type 1 Diabetes is increasing – decreased vitamin D is one of the many possible reasons – Sept 2018
- Peripheral neuropathy pain associated with low vitamin D – Aug 2018
- Importance of Vitamin K – Pizzorno – July 2018
- Diabetes Prevention Program funded by many (Vitamin D would be much better) – Aug 2018
- Early Type 1 Diabetes May Shorten Women’s Lives by 18 Years - Aug 2018
- Diabetics were 4.4 X more likely to die if they had low Vitamin D – July 2018
- Diabetic Foot Ulcer patients had low vitamin D (half had less than 10 ng) – July 2018
- Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis May 2018
- Maternal Diabetes and Risk of Autism in Offspring – JAMA June 2018
- Young Diabetics had 3.8 X higher risk of Parkinson’s (perhaps low Mg or low Vitamin D)– June 2018
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018
- Diabetes 5.6 X more likely if low vitamin D 4 years before – March 2018
All categories associated with Diabetes
Intervention55; Pregnancy42; Infant-Child38; Meta-analysis36; Obesity32; Cardiovascular31; Magnesium25; Skin - Dark24; Intervention - non daily22; Vitamin D Receptor22; Metabolic Syndrome15; Hypertension13; Kidney12; Genetics12; Omega-311; Cognitive10; Depression10; Cancer9; Autoimmune9; Deficiency9; Virus8; Loading dose8; Inflammation8; Vision7; Mortality 7; Rheumatoid Arthritis7; Middle East6; Injection6; Immunity6; Antibiotics, probiotics6; Multiple Sclerosis6; Lupus6; Stroke5; Vitamin K5; Youth5; Vit D Binding Protein5; Bone - Health4; Pain - chronic4; Thyroid and parathyroid4; Books, videos 4; Sports 4; Fortification4 As of Oct 2022 Click to generate detailed associations
Type 1 Diabetes (most are adults)
50+ VitaminDWiki Diabetes pages have T1 or TYPE 1 in the title
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T1 Diabetes in Adults - review April 2022
Type 1 Diabetes: A Systematic Review From 32 Countries and Regions
Download the PDF from VitaminDWiki
T1 Diabetes on web
- GrassrootsHealth New Project Launch - Type 1 Diabetes Prevention! Aug 2018
Prevent T1D with Vitamin D and Omega-3
Increased T1 Diabetes in those >65: 12% 1990, 17% in 2019.
More and More Are Living With Type 1 Diabetes Into Old Age MD Edge June 2024]
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