Vitamin D and physical activity as co-modifiers of muscle health and function - a narrative exploration
Review Ann Med Surg (Lond). 2025 Jun 25;87(8):5046-5055. doi: 10.1097/MS9.0000000000003502.
Inshal Jawed 1, Hafiza Quratul Ain 2, Farah Abdul Razaq 3, Muhammad Umair Qadir 1, Shafaq Jabeen 4, Farah Alam 5, Maham Javaid 6, Mehak Mobin 7, Danaish Kumar 4, Ruhul Rai 8, Syed Ali Farhan Abbas 9, Abu Huraira Bin Gulzar 10, Agha Muhammad Wali Mirza 9, Salma S Alrawa 11, Wajeeha Imam 2
Bone health requires different factors to grow. One of the main requirements is vitamin D. Much of the regulation of calcium levels also affects muscle strength and function, protein synthesis, and other cellular activities. Furthermore, the benefits of vitamin D on the muscular system are comparable to those of physical activity in terms of shaping the structural and functional changes in muscles. Our paper focuses on the synergistic effects of physical exercise and vitamin D on metabolism how they can impact muscle health, including the physiological rationale, outcomes of its deficiency, and measures for counteraction thereto. Here, we outline the effect of combined interventions for optimizing muscle strength.
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