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Falls and Fractures
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- Health Problems and D One pill every two weeks gives you all the vitamin D most adults need No increase in falls, fractures or all-cause mortality when Vitamin D is given monthly or less often– meta-analysis April 2024 More muscle response when have adequate vitamin D Silicon, Vitamin D and Bone Health - multiple studies Bone fractures not reduced with 400 IU of Vitamin D plus Calcium (no surprise) WHI – strange RCT May 2024 100,000 IU of Vitamin D monthly (27 ng) is not enough to reduce fractures and falls – meta-analysis April 2024 Vitamin D deficiency in children: 9%, but up to 75% in children with fractures – April 2024 VitaminDWiki Mega-Search (Interim Version) Vitamiin D Does Not Reduce Fractues in seniors (VITAL 2,000 IU D, no Calcium) - Dec 2022 Bone density improved by monthly 50,000 IU of vitamin D for 6 months – RCT Jan 2021 Italian women taking Vitamin D (Osteoporosis, etc) - Dec 2022 Parkinson’s – Vitamin D, bone density, insomnia, falls, poor sleep, anxiety – March 2019 Seniors Falls and Fractures Risk of Frailty reduced 4X by 4,000 IU of vitamin D – RCT April 2022 Hip fracture risk was reduced by 4 times when Vitamin D was added to SERMS - Jan 2024 Fall prevention - Vitamin D is one of the ways - umbrella review Jan 2024 Most Japanese seniors with bone fractures have less than 10 ng of vitamin D - Jan 2024 MegaSearchOverview Reducing fractures with Vitamin D and Calcium saves 3 dollars for 1 dollar invested – Europe Feb 2017 Risk of Hip fracture cut in half if Vitamin D was prescribed - Aug 2023 Hip fractures are predicted by 10 factors – low Vitamin D is the biggest – Aug 2023 Just 4,000 IU of vitamin D was not enough to halt senior falls – July 2023 Falls and frailty associated with low levels of both vitamins B12 and D3 – June 2023 Fracture treatment 2000 dollars less expensive if also use Vitamin D and Calcium – Feb 2023 Fractures 1.5 X more-likely if low serum Magnesium – meta-analysis March 2023 Forearm fractures in children having low Vitamin D had 3.8 X higher risk of surgery – Aug 2020 Osteoporosis guidelines mention vitamin D - Jan 2023 Low energy bone fractures associated with low vitamin D – Dec 2022 7 X more likely to get hip fracture if have highest level of vitamin A – Jan 2003 5X fewer hip fractures from Parkinson – Alzheimer – Stroke with enough sun – June 2011 Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015 1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017 Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016 Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017 Hip fractures rates have been increasing since 2012 – Feb 2018 Following hip fracture 2,000 IU of vitamin D daily improved quality of life – Feb 2019 Warning - High intake of Vitamin B12 and B6 found to increase risk of hip fracture by 47 percent - 2019 Guideline following hip fracture – 50000 IU vitamin D daily for 7 days – Jan 2013 Hip fractures greatly reduced by sunshine, vitamin D, and vitamin K – meta-analysis Sept 2012 Overview of VitaminDWiki Falls reduced by Vitamin D: 13 percent reduction if more than 700 IU – review of 38 trials – Aug 2022 Study Finds Another Condition That Vitamin D Pills Do Not Help - NYT July 2022 VitaminDWiki interview and transcript - Jan 2022 Perhaps higher risk of fracture if low BMD plus low vitamin D – July 2022 More hip fractures if low vitamin D (2.1X in case-controlled studies) – meta-analysis May 2022 Vitamin D could be restored in 60 days (actually much faster) – June 2018 A call to action: Vitamin D for hip fracture (50,000 weekly for 8 weeks, then bi-weekly – Holick July 2020 93 pcnt of these Lupus patients supplemented with Vitamin D - Nov 2020 Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016 Less than 3 percent of hip fracture patients prescribed enough Vitamin D to make a difference (Malta in this case) – July 2021 Recommends vitamin D after hip fracture ( but not enough and no-bone building co-factors) – May 2021 Bone healing not improved by a single bolus dose of 30,000 IU (no surprise) – RCT April 2021 Belgian Hospital standard of care – test all orthopedic patients for low Vitamin D – June 2020 Increased risk of fracture if high level of Vitamin D (if continue to take Calcium) – umbrella analysis of meta-analyses Nov 2020 Falls are the second largest cause of accidental death in the world (Vitamin D not mentioned) – Oct 2020 3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020 Increasing Vitamin D in aged care facilities to more than 800 IUs did not reduce falls – Oct 2020 Bone increased : Stiffness (Vitamin D), Flexibility (Vitamin K2) – Sept 2020 Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019 Risk factors for death after hip fracture surgery – 7 of the 8 are associated with low vitamin D – Aug 2020 Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019 Hip fractures reduced 16 to 33 percent by any amount of Vitamin D and Calcium – Oct 2019 Fractures reduced by monthly 30,000 IU of Vitamin D, perhaps 100,000 IU would be better – July 2019 France wants to reduce hip fractures by drinking 10 glasses of milk daily – April 2018 Vitamin D predicts good health and long life in seniors, review of 20 cohort studies – Oct 2019 Elderly with low vitamin D fall more often (Parkinson’s in this case) – Aug 2019 Hip fracture rate increases in winter (subtropical Australia too) – Aug 2019 Osteoporosis has no symptoms until a bone breaks Vitamin D and Calcium cost-effectively reduce falls and fractures – April 2019 Osteoporosis treatment – Vitamin D is the most cost-effective – April 2019 Younger Parkinson’s patients had better balance after 10,000 IU of vitamin D for 16 weeks – RCT Feb 2019 Hip fractures worse if both high PTH and low Vitamin D – Jan 2019 Vitamin D not help fractures and falls if not vitamin D deficient – meta-analysis Oct 2018 Bone STRENGTH improved by 2800 IU of Vitamin D (not bone density) – RCT Oct 2018 Vitamin D receptor (TT), which restricts Vit D to cells, is associated with balance problems in seniors – June 2018 Fall and fracture rates vs Vitamin D after standardization – March 2018 400 IU of vitamin D does not prevent fractures – US Preventive Services – April 2018 50,000 IU vitamin D routinely given monthly in New Zealand senior homes since 2011– Dec 2016 Vitamin D In Older Women - Fractures, Frailty and Mortality – Buchebner thesis 2017 American College of Rheumatology Guidelines finally include Vitamin D – June 2017 Most Hip fracture patients had low vitamin D and protein (needed for strong bones) – May 2017 Falls not decreased by 800 IU daily of vitamin D (proven again) – Dec 2016 Stronger hip bone associated with higher levels of vitamin D – Aug 2015 Bones not helped much by vitamin D (low dose or short term) National Osteoporosis Foundation – Feb 2016 Rate of falls reduced 2X by just 1000 IU of vitamin D – RCT Nov 2015 Foot and Ankle Fracture Healing – vitamin D appears promising for everyone– review May 2015 Falls are prevented by vitamin D - provided you get enough - Dec 2014 Mobility device – 50 percent increased use (perhaps decreased vitamin D levels) - May 2015 Fallers often had less than 20 ng of vitamin D – meta-analysis April 2014 Hip replacement 2X more likely if hip bone surgery was during winter (low vitamin D) – Dec 2014 More aged are falling - even age-adjusted - Nov 2014 Seniors with adequate vitamin D could rebalance themselves 80% faster, and thus not fall as often – 2013 To (Vitamin) D or Not to D - That Is the Question – Endocrinology conf. debate April 2013