Overview Alzheimer's-Cognition and Vitamin D

• FACT: Cognitive decline is 19X more likely if low vitamin D
• FACT: Dementia is associated with low vitamin D levels.
• FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
• FACT: Dementia is associated with low vitamin D - many studies
• FACT: Alzheimer's Disease is 4X less likely if high vitamin D
• FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
• FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
• OBSERVATION: Reports of increased vitamin D levels result in improved cognition
• OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
• OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
• OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
• OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
• OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
• OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
• OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
• OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
• OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
• OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
• OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
• OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
• OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
  • It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home. $75/month.
• FACT: Vitamin D is extremely low cost and has very very few side effects
• CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
• PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
  There are 13+ Alzheimer’s meta-analyses in VitaminDWiki
  There are 97+ Alzheimer’s studies in VitaminDWiki
  Dementia is associated with low vitamin D - many studies 50+ studies
  16+ studies in both categories Cognitive and Omega-3

---

---

A summary of the key points of this page by Claude2 - July 2023

The PDF provides an overview of the evidence linking vitamin D deficiency to increased risk of Alzheimer's disease and cognitive decline. It highlights numerous studies, facts, and observations supporting vitamin D's role in brain health.

Some key facts presented:

• Cognitive decline is 19 times more likely with low vitamin D levels.
• Dementia and Alzheimer's diseases are consistently associated with low vitamin D in many observational studies.
  • Alzheimer's is 2.3 times more likely in the elderly with low D.
• Every single risk factor for Alzheimer's disease is also a risk factor for low vitamin D.
• As vitamin D levels in the elderly continue to decline, cognition gets worse.
• Increasing vitamin D has been observed to improve cognition in some reports.
• Alzheimer's patients are 3 times more likely to have a malfunctioning vitamin D receptor gene which can prevent vitamin D from getting into cells.

Some key observations:

• In animal studies, vitamin D has been found to help remove amyloid brain plaque associated with Alzheimer's.
• Exposure to DDT, which decreases vitamin D, increases Alzheimer's risk by up to 3.8 times.
• Genes linked to Alzheimer's all also restrict vitamin D function.
• There are at least 11 ways vitamin D may help reduce Alzheimer's disease risk and pathology.
• Daily vitamin D supplementation around 4,000 IU improved cognition in Alzheimer's patients in a clinical trial.

In summary, the PDF compilation of references indicates substantial evidence for a link between low vitamin D and increased Alzheimer's and cognitive decline. It advocates vitamin D supplementation as a low-risk, low-cost prevention and treatment strategy. Combining vitamin D with omega-3 is highlighted as another promising approach currently being tested.

---

Countries consuming more Omega-6 (which bocks Omega-3) have higher risk of Alzheimer's Disease - preprint Aug 2024

Change in Age Standardized Alzheimer Disease Incidence associated with a 1 unit increase in country-level lipid (β)
Omega6 PUFA (% of energy intake) 2.44 p=1.38x10-9
No such attachment on this page

---

VitaminDWiki - Many Neurological Diseases fought by Vitamin D - Dec 2022

---

VitaminDWiki - Cognitive category contains

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

391 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (8 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (52 studies), Intervention (20 studies), Meta-analyses (22 studies), Depression (24 studies), Parkinson's (24 studies)
Click here for details

Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014

---

Dr. Campbell Video on Dementia/Alzheimer's and Vitamin D - July 2023

YouTube 16 minutes

---

16+ Items in both categories Cognitive and Vitamin D Receptor

---

Alzheimer's before symptoms can now be detected, many ways to prevent having symptoms - May 2024

BrainScan - Pioneering Diagnostics to Prevent and Reverse Cognitive Decline 64 minutes, Apollo Health, Dr. Bredesen
Similar to detecting pre-Diabetes allows proactively stopping progression to diabetes.
Perhaps we should call this a test for pre-Alzheimer's
Far better than the gene test which mearly shows the risk of getting Alzheimer's.

---

13+ VitaminDWik Meta-analyses with ALZHEIMER in title

This list is automatically updated

• Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018 Has the following:

---

97+ VitaminDWiki pages with ALZHEIMER in the title

This list is automatically updated

---

Cognition and Dementia in VitaminDWiki

• Cognitive category listing has 391 items along with related searches
• Poor cognition associated with low vitamin D in elderly (Asians now too) – meta-analysis March 2016
• Memory loss linked to low vitamin D – Nov 2015
• Dementia risk significantly increased if have 4 chronic diseases – all associated with low vitamin D – Sept 2015
• Dementia associated with low vitamin D in two thirds of studies – systematic review May 2013
• Cognitive Impairment 4X more likely if low vitamin D (less than 20 ng) – Feb 2014
• Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis July 2013
• Dementia surprisingly associated with low vitamin D (should not a surprise) – Aug 2014
• Low vitamin D associated with cognition in women who were 5 years older – Oct 2013
• 'Senior moment" 25X more likely with low vitamin D – Feb 2012
• Fewer white spots in MRI brain scans if had more vitamin D – Jan 2014
• Search VitaminDWiki for dementia anywhere in text 484 items Jan 2016
• Search VitaminDWiki for dementia in title 19 items as of Jan 2016
• Dementia less likely with increased levels of Magnesium etc.
• 3rd most common dementia perhaps might also be associated with low vitamin D: Lewy Body
• Cognitive impairment 4X more likely when vitamin D less than 10 ng – Nov 2010
• Hypothesis - Vitamin D reduce risk of Dementia - 2009 by Grant - a file, not a web page
• Cognitive impairment 2.4X more likely if low vitamin D – July 2012
• Winter blues and depression 269 items
• Those who were 80 had better cognition and standing if higher level of vitamin D – Sept 2012
• Dementia 13X more likely in elderly with low vitamin D – May 2014
• Cognition and vitamin D – summary of expert opinions – July 2014 Annweiler
• Vitamin D improved brains in aging rats – Sept 2014 intervention
• Chance of Dementia increased 3 percent for every 1 ng less of vitamin D – Feb 2015
• Cognition declined somewhat if low vitamin D – March 2014
• Influence diagram for vitamin D and cognition - 2008
• See also Overview Parkinson's and Vitamin D

---

20Items in BOTH Cognition and Intervention categories

   give Vitamin D and look for improved cognition

---

VitaminDWiki - 52 studies in both categories Cognitive and Omega-3

This list is automatically updated

---

VitaminDWiki - 12 studies in both categories Cognitive and Virus

This list is automatically updated

---

200 patients nicely treated for all 3 types of Alzheimer's by adjusting several of 34 variables - Sept 2017

• Variables include diet, exercise and supplements
• I would not normally have believed this claim except that it was described by Dr. Doidge, whom I trust after reading his book Missing Microbes
• includes link to scientific publication and book The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline 2017

update at The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc. including 3 books, latest Aug 2021

---

Alzheimer’s might be associated with Herpes virus (which is associated with low Vitamin D) - Feb 2023

Could Alzheimer’s be caused by an infection? The Guardian   Many hints

• "“When people with herpes were treated with a standard antiviral drug, it decreased their risk of dementia nine-fold.”"
• "...– examined postmortem brain samples from patients, she found greater amounts of the virus’s DNA than in people who had not died of the disease."
• "Studies in the UK, France and Scandinavia suggested that people who had been infected with herpes were more likely to get Alzheimer’s. "
• "...giving people a shingles vaccine seems to lessen their risk of developing Alzheimer’s"

---

Diets reduce the risk of Alz

• The Alzheimer’s Solution - 2017
• The MIND Diet for Alzheimer’s Prevention 2021
• Mediterranean Diet, Alzheimer Disease, and Vascular Mediation doi:10.1001/archneur.63.12.noc60109
  • 495 refernces as of Jan 2023
• Alzheimer’s Disease - Boost Brain Health With a Plant-Based Diet web page

Omega-3 stopped mild AD progression - 2006

• Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial 10.1001/archneur.63.10.1402.
  • 957 citations as of Jan 2023

---

Alzheimer's patients had lower levels of vitamin D in Cerebrospinal Fluid - Feb 2022

Vitamin D in Alzheimer's Disease: Low Levels in Cerebrospinal Fluid Despite Normal Amounts in Serum
J Alzheimers Dis. 2022 Feb 15. doi: 10.3233/JAD-215536
Jelena Zugic Soares 1 2 3, Jørgen Valeur 3, Jūratė Šaltytė Benth 4 5, Anne-Brita Knapskog 6, Geir Selbæk 2 6 7, Golchin Arefi 8, D Gregor Gilfillan 8, Anita Tollisen 3, Nenad Bogdanovic 6 9, Renate Pettersen 1

Background: Vitamin D insufficiency has been suggested as a dementia risk factor.

Objective: In this cross-sectional, explorative study we investigated whether levels of vitamin D in cerebrospinal fluid (CSF) are lower in patients with positive biomarkers of Alzheimer's disease (AD) compared to cognitively healthy controls and whether polymorphisms of the vitamin D receptor (VDR) gene, FokI, BsmI, ApaI, and TaqI, are associated with levels of vitamin D in CSF and cognition.

Methods: We included 100 patients≥65 years assessed for cognitive impairment and 76 cognitively healthy controls. Levels of 25-hydroxyvitamin D (25(OH)D) in both serum and CSF, and VDR polymorphisms were analyzed.

Results: The mean level of 25(OH)D in serum was 78.6 (SD 28.9) nmol/l. While serum levels of 25(OH)D were not significantly different between the groups, CSF levels of 25(OH)D were significantly lower in patients with positive AD core biomarkers (p = 0.001) compared to patients without such biomarkers. Individuals with the BsmI major homozygote genotype had significantly lower results on a 10-word delayed recall test (p = 0.044) and verbal fluency test (p = 0.013), and individuals with the TaqI major homozygote genotype had significantly lower results on a verbal fluency test (p = 0.030) compared to individuals with the corresponding minor homozygote genotype.

Conclusion: Patients with positive AD core biomarkers have low CSF levels of 25(OH)D, despite sufficient serum levels. CSF levels of 25(OH)D do not seem to be affected by any of the four VDR gene polymorphisms. TaqI and BsmI major homozygote genotypes might be at increased risk for development of cognitive decline.

---

Playing music from a patient's youth helps with dementia, Alzheimer's, Parkinson's

• Search web for dementia "music therapy" 700,000 web pages April 2019
• Spectacular results in both the short term and 6 months later

On the WEB

Type 3 Diabetes?] New York Times Sept 2012

• Idea has been around since 2005. Brain cells become insulin resistant - first noticed by Dr. Alzheimer
• people with diabetes are at least twice as likely to get Alzheimer’s
• Alzheimer’s Disease as Type 3 Diabetes: Common Pathophysiological Mechanisms between Alzheimer’s Disease and Type 2 Diabetes - Feb 2022 free PDF
• Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer’s Disease - Feb 2020 FREE PDF
• Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease - April 2020 Free PDF
• Machine Learning Selection of Most Predictive Brain Proteins Suggests Role of Sugar Metabolism in Alzheimer’s Disease -|Feb 2023
• The Full Spectrum of Alzheimer’s Disease Is Rooted in Metabolic Derangements That Drive Type 3 Diabetes May 2019
• Sugar in Beverage and the Risk of Incident Dementia, Alzheimer’s disease and Stroke: A Prospective Cohort Study - Nov 2020
• PubMed Alzheimer's AND Insulin in title 475 items as of March 2023
  • "Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages." Oct 2017 free PDF online
  • "Insulin signaling: An opportunistic target to minify the risk of Alzheimer's disease." Sept 2017
  • "Insulin resistance in Alzheimer's disease." May 2017
• Vitamin D and neurology Wikipedia
  has sections on Dementia: Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Epilepsy and seizures, Schizophrenia
• Alzheimer's nutrient status - July 2014 including vitamin D - attached at the bottom of this page
• Vitamin D Deficiency and Alzheimer Disease: Common Links July 2015, Publisher wants $40 for the PDF
  "Based on this accumulation of studies, we propose that VitD screening should be performed at least in those individuals at risk for VitD deficiency and AD"
• Is It Alzheimer’s, or A.D.H.D.? New York Times Sept 2015
  3 % of Dutch over 60 have A.D.H. D. It overlaps with age-related cognitive decline
• Probiotics improve cognition in Alzheimer's patients RCT Nov 2016
  Nothing about Vitamin D. 12 weeks of probiotics for Alzheimer's patients increased mental test score from 8.7 to 10.6 (max score = 30)
• Should I Take The Gene Test For Alzheimer's? GreenMed Info. April 2017
  Yes: should have a gene test, especially if Alz runs in the family
  If you have two copies of APOE4 gene you can be at 12X risk of getting Alzheimer's
  Personal note: I (Henry Lahore) have just one copy of the gene, so I have a 3X risk - the only gene risk from my 23andMe report
  • Supplementing vitamin D, etc virtually eliminates my increased risk
  • 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
• Age-adjusted = increase is NOT due to having a larger elderly population

_

• 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
  Age-adjusted = increase is NOT due to having a larger elderly population

• 7 Conditions Masquerading As Dementia GreenMed Info Aug 2018
  Does not mention which the 7 are, but does point to huge success at reversing dementia - using major changes - including supplementing with Vitamin B12, vitamin D, CoQ10 and Omega-3
• From Fight Aging On Increasing Your Chances of Avoiding Alzheimer's July 2011
  In many ways, Alzheimer's Disease looks a lot like type 2 diabetes - it can be argued that there are some biochemical similarities in the underlying mechanisms, Alzheimer's appears to be a lifestyle disease to some degree, and the two conditions have many of the same risk factors, such as obesity and being sedentary. So: " Over half of all Alzheimer's disease cases could potentially be prevented through lifestyle changes and treatment or prevention of chronic medical conditions. ...
  Analyzing data from studies around the world involving hundreds of thousands of participants, [researchers] concluded that worldwide, the biggest modifiable risk factors for Alzheimer's disease are, in descending order of magnitude, low education, smoking, physical inactivity, depression, mid-life hypertension, diabetes and mid-life obesity. ...

In the United States, [researchers] found that the biggest modifiable risk factors are

• physical inactivity,
• depression,
• smoking,
• mid-life hypertension,
• mid-life obesity,
• low education and
• diabetes. ...

Note: EVERY SINGLE ONE of the above associations with Alzheimer's Disease is also associated with low vitamin D:

• Physical inactivity - not get out in the sun
• depression category - a common result of low vitamin D:
• Smoking - well known to consume vitamin D
• mid-life hypertension a result of low vitamin D:
• mid-life obesity - which results from low vitamin D, and Obesity makes vitamin D levels even lower
• Low education - take far fewer nutritional supplements - due to cost, knowledge, belief
  • Note: low education is also associated with dark-skinned people, who get less vitamin D from the sun
• Alz treated with multiple nutrients: Vit D 40-60 ng, Omega-3 index > 8, Iron, Selenium, B12, etc
• diabetes - a result of low vitamin D:

---

Clinical Trials for Cognition and Vitamin D INTERVENTION

• Clinical Trials for Alzheimer OR Cognition and Vitamin D INTERVENTION 43 trials as of Sept 2021
• Alzheimer's slowed with 100,000 IU vitamin D monthly
• Parkinson's slowed with 7,400 IU vitamin D daily
• Parkinson's slowed with 10,000 IU vitamin D daily

---

Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails - May 2016

J Alzheimers Dis. 2016 May 11;53(2):419-44. doi: 10.3233/JAD-150943.
Landel V1, Annweiler C2,3, Millet P1,4, Morello M1,5,6, Féron F1.

Fig. 2. Proposed mechanisms of vitamin D-mediated multitargeted effects in AD. Vitamin D imbalance is proposed to alter mechanisms implicated in aging and AD pathogenesis. Suggested protective effects of vitamin D supplementation concern regulation of vascular processes and oxidative stress, calcium homeostasis, neurotransmission, modulation of immune and inflammatory processes, and direct impact on amyloidogenesis, ultimately improving cognitive functions.

 Download the PDF from VitaminDWiki

---

Age-adjusted Death rates: Alzheimer's has been increasing the fastest

Big increase if both parents had Alzheimer's

54% of ALL people, of all ages, are now "touched" by Alzheimer's

Alzheimers Association facts and figures 2016 - nothing about vitamin D

 Download the PDF from VitaminDWiki
Has A LOT of information, including the following

• "Compared with no TBI, moderate TBI is associated with twice the risk of developing Alzheimer’s and other dementias, and severe TBI with 4.5 times the risk"
• "1 in 9 people over age 65 has Alzheimer's Disease"
• "Among people aged 70, 61% of those with Alzheimer's Disease are expected to die before age 80 vs 30% of those without Alzheimer's' "
• "15 million Americans provide unpaid care for people with Alzheimer’s disease and other dementias."
• "Total payments for Health Care, Long term care, and Hospice are estimated to be $236 billion in 2016 for people with Alzheimer’s disease and other dementias."
  This $236 Billion does NOT include the costs due to caregiving by family, lost time from work, etc.

Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013

Alzheimer's in more than half of hospital patients over age 65

Half of caregiving for 6+ years is due to Alzheimer's or other dementia

Work changes due to Alzheimer's or Dementia caregiving

---

What if we could delay the onset of Alzheimer's by 5 years - Alzheimer's Association - 2015

 Download the PDF from VitaminDWiki

Looks like about half of the people would not have Alzheimer's costs (die sooner?)

---

Cognition other than Vitamin D monotherapy

• Reversal of cognitive decline with multitherapy (not monotherapy) – Sept 2014
• Alzheimer's disease most likely will need more than monotherapy such as vitamin D – May 2013
• Alzheimer risk reduced by combination of memantine and vitamin D (patented) – Jan 2014
• Alzheimer’s and Vitamins D, B, C, E, as well as Omega-3, metals, etc. – June 2013
• Alzheimer's may be treated by vitamin D3 and curcumin – March 2012
• Magnesium deficiency is also associated with low vitamin D and poor mental health

• Boost Memory, Regenerate Neurons with Ginko GreenMed Info April 2015
  Has links to >100 Ginko studies
• Vitamin E May Offer Benefits for Patients with Alzheimer’s Disease Mercola Jan 2014
  2000 IU of Vitamin E (alpha tocopherol) slows up the progression of Alzheimer's: by 6 months in a 2 year period
• American Osteopathic Association
  "Benzodiazepines(such as Valium) ineffective in treating anxiety disorders may increase dementia risk: Osteopathic psychiatrists encourage patients to review treatment options to improve outcomes, reduce risks." ScienceDaily. ScienceDaily, 5 October 2015.
  84% increases the chance of Alzheimer's if take Benzodiazepines for >6 months
• Marijuana Compound Found Superior To Drugs For Alzheimer's Sept 2012
  THC reduces plaque buildup. Inhibit the AChE enzyme better than commercial drugs
• Posit Science 18 hours of use of software cut in half the risk of getting Dementia July 2016
  2,832 community-dwelling and generally healthy participants, with an average age of 74. RCT, 10 years
  Note by HenryLahore at VitaminDWiki - I have been using Posit Science software for 5+ years - it is EXCELLENT

---

Items in BOTH Cognition and Omega-3 categories

---

APOE4 gene greatly increases the risk of AD, but had been a benefit during childhood

The APOe4 gene protected our ancestors and helped them get through the childbearing years by attacking parasites and micro-organisms with oxidative stress. It is only in modern times that people live long enough for the same oxidative stress to work against us in old age.
A book, Survival of the Sickest,(2008) points out roughly the same concept in a number of other diseases which long ago helped our ancestors get through plagues, ice ages, parasites, famine, etc. It's a fascinating concept and it makes sense. By Rich H, Jan 2017
 Download the PDF of the book from VitaminDWiki

---

Small amount of Lithium slows dementia in Alzheimer's

• Life Extension Magazine, Dec 2016, Nothing about Vitamin D.
  Boron may provide a similar benefit, at far lower cost
   Download the PDF from VitaminDWiki
• Lithium as Nutrient - 2015 Alz and many other health problems
       Download the PDF from VitaminDWiki
• Association Between Lithium Use and Risk of Alzheimer's Disease PubMed Dec 2016
  looked ay 200,000 elderly. 1.8X less likely to get Alzheimer's if had been taking Lithium
• Lithium to the Rescue. PubMed Feb 2016
       Download the PDF from VitaminDWiki

---

Saffron treats Alzheimer's as well as drugs, but without side affects - June 2021

__Saffron Put to the Test for Alzheimer’s Dr. Greger

• Study was funded by BIG SAFRON = Iran (not BIG PHARMA)
• Co-encapsulation of vitamin D3 and saffron petals’ bioactive compounds in nanoemulsions: Effects of emulsifier and homogenizer types - June 2020 https://doi.org/10.1111/jfpp.14629 FREE PDF
• Note: Various suppliers of Safron in combination with Vitamin D

Rate of a rare form of early-onset Alzheimer's associated with Aluminium - 2017

• Scientists Prove Link Between Aluminum and Early Onset Alzheimer’s Disease GreenMed Info
  Early Onset occurs in 2-3 % of Alzheimer’s Disease
  No indication of rate increase if have high exposure to Aluminum

---

Bill Gates put $50 million into Alzheimer's Research - Fall 2017 (no mention about Vitamin D)

• Why I’m Digging Deep Into Alzheimer’s Bill Gates Blog
  "A person with Alzheimer’s or another form of dementia spends five times more every year out-of-pocket on healthcare than a senior without a neurodegenerative condition"
  For example, we don’t fully understand why you are more likely to get Alzheimer’s if you’re African American or Latino than if you’re white"
  VitaminDWiki suspects that the increased risk is due to lower levels of vitamin D in those with dark skins
• Bill Gates' newest mission: Curing Alzheimer's CNN
  "Since 2002, there have been more than 400 Alzheimer drug trials run and yet no treatments"
• Why Bill Gates-backed a $30 million fight against Alzheimer’s July 2018
  give profit incentive to groups deploying early detection of Alzheimer's
  His family (father?) has Alzheimer's

---

Risk of Dementia reduced 50% by just using Brain Plasticity Software for just 13 hours - Nov 2017

Posit Science - 10-year experiment, full free text online
Speed of processing training results in lower risk of dementia

---

Types of Mental Disorders (no mention of low vitamin D) - 2017?

Bipolar Bandit has detailed descriptions and references

---

---

Alzheimer's risk reduced by Vit D, Vit C, Omega-3, Zinc, etc more than cancels the increased risk due to APOE-4 problems - July 2018

Why Is Modern Medicine Aiming To Reduce Risk For Alzheimer's Disease With Expensive Gene Editing Technology When Fish Oil, Antioxidants & Metal Chelation Are More Effective & Economical? Bill Sardi

1. The alternative therapies cancel the increased risk of Alzheimer's due to gene problems
   Gene Therapy ignores the other causes of Alzheimer's and other forms of dementia
2. The alternative therapies are far far less costly than gene therapy
   might cost $200 Billion to provide gene therapy to everyone with the APOE-4 gene problem

Copper + saturated fat (cholesterol) found to increase the rate of Cognitive Decline by 3X

• Alzheimer’s Disease and Dietary Copper Dr Gregor Oct 2018
  VitaminDWiki wonders if Vitamin D reduces Copper or Cholesterol
• Cholesterol reduced by Vitamin D plus Calcium – RCT March 2014
• Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018

---

Alzheimer's rate is especially increasing in groups at high risk of Low Vitamin D (Dark Skin)

 

 

reference for both graphics

---

Alz is strongly related to Mercury (dental fillings), Emeramide is a Mercury chelator was developed - Jan 2020

Hallmarks of Alzheimer's Are Stimulated by This Substance Mercola
Interview of Boyd Haley, Ph.D., Video and Transcript

• {...enzyme creatine kinase, which is a fundamental enzyme, is 98 percent inhibited in Alzheimer's patients..."
• "All Biochemical Abnormalities and Hallmarks of Alzheimer's Are Stimulated by Mercury"
• In 2014 Haley wrote a paper "Evidence Supporting a Link Between Dental Amalgams and Chronic Illness, Fatigue, Depression, Anxiety and Suicide."
• "The Relationship of Toxic Effects of Mercury to Exacerbation of the Medical Condition classified as Alzheimer’s Disease" byHaley
  • is  attached - date unknown

---

>12 million will have Alzheimer’s in the US in 2050

web

---

Saffron as good as Alzheimer's drug, but without the side effects - June 2021

• Saffron Put to the Test for Alzheimer’s Dr Greger
  • Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial - 2014
  • Note: As of June 2021 various suppliers produce Safron in combination with Vitamin D
  • Also:"Co-encapsulation of vitamin D3 and saffron petals’ bioactive compounds in nanoemulsions: Effects of emulsifier and homogenizer types" - June 2020 - https://doi.org/10.1111/jfpp.14629 PDF costs $14

---

Rates of Death due to Alz and Dementia vary a lot between countries

World Heath Rangings July 2021
Example: US death rate is 6X of that of Japan (34.8 vs 5.2)

---

Daily multivitamin slowed cognitive decline by 60%: placebo-controlled trial - Nov 2021

Multivitamins, but not cocoa, tied to slowed brain aging MDEdge Nov 11, 2021
Better and better during the trial, but plateaued at 2 years
Presented at a conference. A comment was made that the benefit might be from Vitamin B12 in the multivitamin

---

Calcitriol appears to worsen Alzheimer's in both mice and humans - 2022

 Download the PDF from VitaminDWiki

---

Title change made Nov 2021 caused the visitor count to reset.
There have actually been 190177 visitors to this page since it was originally made

---

60% reduced decline in moderate Alzheimer's symptoms by just diluting blood with water - Feb 2024

Can Getting Transfusions of Young Blood Slow Aging? Dr. Greger video
Transcript
Vampires 2.0? The ethical quandaries of young blood infusion in the quest for eternal life.” In an episode of the TV series Silicon Valley entitled “The Blood Boy,” a tech guru hires a young assistant from whom to transfuse pints of blood in an attempt to slow down his aging. The restoration of youth by bathing in or drinking the blood of youth is a centuries-old trope dating back at least to the futile attempt of ailing Pope Innocent VIII, who in the 1490s failed to live up to his name by apparently drinking the blood of three ten-year-old boys who—though a bargain “costing only one ducat apiece’’—died in the process.

Might there be something to it, though? Though young blood did not have a significant impact on lifespan otherwise, infusing the blood of young animals into old did have rejuvenating effects on multiple organs, similar to full-blown parabiosis, as I talked about in the last video. In fact, not only does the infusion of young mouse blood improve age-related cognitive dysfunction in old mice, young human blood—taken from umbilical cords—worked too (in mice engineered to not reject the foreign tissue). This led to ongoing clinical trials offering weekly infusions of blood products from young donors to patients with mild to moderate Alzheimer’s disease. But there may be an easier way.

Yes, the injection of blood from young mice into old can improve memory and learning, suggesting there’s some kind of restorative youth factor. But the injection of blood from old mice into young can worsen memory and learning, suggesting that instead there’s some sort of debilitating aging factor. Or maybe the old blood is just diluting the revitalizing factor in the young mouse. Or, for that matter, maybe the young blood is diluting the debilitating factor in the old mouse. The fact that old blood appears to make things worse more than young blood makes them better suggests maybe the latter is the case. But you don’t know until you put it to the test.

Ready for a mind-blowing shift in perspective? Instead of infusing young blood into old mice, researchers at UC Berkeley just diluted the blood of old mice by siphoning off the plasma (the liquid portion of the blood), and essentially replacing half of it with water. If the regeneration seen in heterochronic parabiosis and blood transfusions was due to some fountain of youth factor in young blood, then nothing should happen, right? But if all the young blood was doing was diluting some debilitating aging factor, then the water should work just as well. And it did. The rejuvenation in the liver was similar to parabiosis or transfusion, and in the muscles and the brain, it was even better. So, most, if not all, the benefits could be replicated by simple dilution, including an improvement in cognitive capacity.

That’s good news, since there’s already an FDA-approved procedure in use today known as therapeutic plasma exchange. It’s usually used to filter out toxins or autoimmune antibodies, but why not try using it to try to dilute old blood to treat Alzheimer’s disease? And that’s exactly what researchers did.

Hundreds of Alzheimer’s patients were randomized to a therapeutic plasma exchange procedure or a placebo (sham) procedure. And though it didn’t seem to help those with mild Alzheimer’s disease, those with moderate Alzheimer’s randomized to the real procedure experienced about 60 percent less cognitive and functional decline over a period of 14 months. This is in stark contrast to mainstay treatments for Alzheimer’s, like the drug memantine, that can help with symptoms but don’t actually alter the course of the disease. And the added advantage over blood transfusions, as a Director of an Institute of Biomedical Ethics put it: “There is something peculiar about the old literally feeding on the young.”
References

• Kim TW, Park SS, Park JY, Park HS. Infusion of plasma from exercised mice ameliorates cognitive dysfunction by increasing hippocampal neuroplasticity and mitochondrial functions in 3xtg-ad mice. Int J Mol Sci. 2020;21(9):3291.
• Ma J, Gao B, Zhang K, et al. Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases. Brain Res Bull. 2019;153:15-23.
• Lavazza A, Garasic M. Vampires 2.0? The ethical quandaries of young blood infusion in the quest for eternal life. Med Health Care Philos. 2020;23(3):421-432.
• Kang S, Moser VA, Svendsen CN, Goodridge HS. Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease. Commun Biol. 2020;3(1):69.
• Learoyd P. The history of blood transfusion prior to the 20th century--part 1. Transfus Med. 2012;22(5):308-314.
• Shytikov D, Balva O, Debonneuil E, Glukhovskiy P, Pishel I. Aged mice repeatedly injected with plasma from young mice: a survival study. Biores Open Access. 2014;3(5):226-232.
• Biller-Andorno N. Young blood for old hands? A recent anti-ageing trial prompts ethical questions. Swiss Med Wkly. 2016;146:w14359.
• Fernández-Zarzoso M, Gómez-Seguí I, de la Rubia J. Therapeutic plasma exchange: Review of current indications. Transfus Apher Sci. 2019;58(3):247-253.
• Mehdipour M, Mehdipour T, Skinner CM, et al. Plasma dilution improves cognition and attenuates neuroinflammation in old mice. Geroscience. 2021;43(1):1-18.
• Mehdipour M, Skinner C, Wong N, et al. Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin. Aging (Albany NY). 2020;12(10):8790-8819.
• Loeffler DA. Ambar, an encouraging alzheimer’s trial that raises questions. Front Neurol. 2020;11:459.
• Rebo J, Mehdipour M, Gathwala R, et al. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nat Commun. 2016;7:13363.
• Castellano JM, Mosher KI, Abbey RJ, et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature. 2017;544(7651):488-492.
• Boada M, López OL, Olazarán J, et al. A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer’s disease: Primary results of the AMBAR Study. Alzheimers Dement. 2020;16(10):1412-1425.

short url = http://is.gd/dcognition