Gout and Vitamin D - many studies

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12 Reasons to believe that Gout is associated with low vitamin D

Reasons to believe that Gout is associated with low vitamin D

1. Acute gouty arthritis is seasonal. 1998
   Increased by 32% in Spring (when vitamin D levels are the lowest)
2. Clinical Trials for Gout and Vitamin D
   Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function
   Good: 50,000 IU weekly, unfortunately: D2, not D3
3. Vitamin D reduces Rheumatoid arthritis 118 items
4. Vitamin D reduces Pain 168 items
5. Vitamin D reduces Inflammation category listing with 175 items
6. Higher incidence of gout with age (less vitamin D and gastric acid as you get older)
7. Increased gout at higher Latitude (Gout and Goutiness a 1899 book
8. Increased gout with soda pop
   JAMA study from 2010.2 women >2 cans of soda daily 2X more likely to develop gout (Note that soda decreases vitamin D levels)
9. 2X more Gout if Dark Skin
   WikiPedia gout is twice as likely in African American males as it is in European Americans
10. Gout and Calcium and vitamin D
    Calcium and Vitamin D. The relationship of gout to calcium and vitamin D is complex.
    Gout is associated with insulin resistance, low vitamin D levels, and inflammation, all of which interfere with muscle synthesis.
    One study has found that patients with gout have lower vitamin D3 levels correlated with higher urate.
11. Increased gout recently (along with increased number of people being vitamin D deficient)- both blacks and whites
    New Zealand 2009 publication
    
    Gout incidence has been increasing (while vitamin D has been decreasing)
    
12. Gout has increased, but appears to be correlated with obesity/ hypertension 2011
    note: both obesity and hypertension are associated with low vitamin D {FONT}

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4X less likely to die of Gout if 40 ng of Vitamin D - Aug 2024

Association of serum 25-hydroxyvitamin D concentrations with all-cause and cause-specific mortality among individuals with gout and hyperuricemia
Nutrition Journal Volume 23, article number 89, https://doi.org/10.1186/s12937-024-00992-8
Ke Liu, Xuanni Lu, Anqi Wang, Weiwei Chen, Ying Chen, Jiayu Li, Xiaohui Sun, Lin Huang, Zhixing He, Chengping Wen, Yingying Mao & Ding Ye

Background
We aimed to probe the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among patients with gout and hyperuricemia (HUA).

Methods
The study included 1169 gout patients and 7029 HUA patients from the National Health and Nutrition Examination Survey (NHANES) 2007–2018 and 2001–2018, respectively. The association between serum 25(OH)D and mortality was evaluated by Cox proportional hazard and restricted cubic spline models.

Results
Among participants with gout and HUA, the weighted mean concentrations of serum 25(OH)D were 71.49 ± 30.09 nmol/L and 64.81 ± 26.92 nmol/L, respectively. Vitamin D deficiency occurred in 29.68% of gout patients and 37.83% of HUA patients.
During 6783 person-years of follow-up among gout patients, 248 all-cause deaths occurred, among which 76 died from cardiovascular disease (CVD) and 49 died from cancer.
1375 HUA patients were recorded for all-cause mortality during 59,859 person-years of follow-up, including 427 CVD deaths and 232 cancer deaths.
After multifactorial adjustment, per one-unit increment in natural log-transformed 25(OH)D was associated with lower risk of 55% all-cause mortality and 61% CVD mortality among gout patients, and a 45% reduced risk of cancer mortality among HUA patients.
Restricted cubic splines showed a U-shaped relationship with all-cause and CVD mortality among HUA patients, with inflection points of 72.7 nmol/L and 38.0 nmol/L, respectively. The results were robust in subgroup and sensitivity analyses.

Conclusions
Serum 25(OH)D was negatively linearly correlated with mortality among gout patients, whereas U-shaped correlated with mortality in HUA patients. These results indicate that adequate vitamin D status could prevent premature death.
 Download the PDF from VitaminDWiki

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Vitamin D and Gout: Facts, etc.

FACT: Gout increases with age
FACT: Gastric Acid/digestion decreases with age
FACT: Coffee increases gastric acid
FACT: Coffee decreases gout (known since 1672)
FACT: Vitamin D increased digestion
FACT: Vitamin D decreases Gout
CONCLUSION: Improved digestion ==> reduced gout
Hypothesis: Other ways to Increase digestion, such as HCL or digestive enzymes, will also decrease gout
Note: Vitamin D reduces gout by at least the following ways:

1. improving digestion
2. improving kidney function
3. reducing pain
4. reducing inflammation

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• Gastic acid decreases with age has the following chart

• More Uric acid (from incomplete digestion of meats) is a problem if low gastric acid or poor liver/kidney
• Gout is reduced with coffee

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• Effects Of Caffeine And Coffee On Heartburn,. . .
  "Coffee is highly acidic and it can stimulate the hypersecretion of gastric acids."
  "Decaffeinated coffee has been shown to increase acidity to a greater degree than either regular coffee or caffeine alone"
• HOW TO TREAT GOUT, JOINT PAIN.... HAVE HCL THERAPY AND DON’T EAT AFTER 6 PM
  HCL increases gastric acid
• Search Google for (hcl OR "hydrochloric acid") gout > 400,000 web pages as of April 2016
  Many companies on Amazon sell HCL with enzyme to increase stomach acid
• 1652 Advertisement For Coffee:"It is excellent to prevent and cure the Dropsy, Gout, ...
• Association between vitamin D insufficiency and elevated serum uric acid among middle-aged and elderly Chinese Han women
  2.4X more likely to have elevated uric acid if low vitamin D and elderly  The 2013 study
• Gout pateints with low vitamin D were 3.8 X more likely to be depressed Dec 2018
• Vitamin C and Gout

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See also VitaminDWiki

• Overview Kidney and vitamin D and Gout is strongly associated with poor kidney function
• Excess Uric Acid associated with low vitamin D
• Gout attacks associated with low Omega-3 – Dec 2015
• Gout, cholera, scarlet fever, TB all increasing in the UK (low vitamin D) – Feb 2019
• Criteria to associate a health problem with low vitamin D contains the following

Many reasons why vitamin D deficiency has become epidemic which includes the following chart

Gout has the following chart

See also web

• Gout and Vitamin D Gout and You
  Review of research. 2015?
  "Gout is quite common and affects about 3.9% or 8.3 million adults in the United States, about 6 million men and 2 million women."
• Gout and Magnesium also from Gout and You
• Vitamin D for Gout: Get It While It Lasts! Goutkiller ebook
• Clinical Trial of Vitamin D to reduce gout renin angiotensin system
• Hypothesis: Vitamin D deficiency is due to malfunctioning renin angiotensin system – Jan 2013 in VitaminDWiki
• Sleep Apnea Is Tied to Gout New York Times Oct 2015
  Those with Sleep Apnea has 50% increased chance of having Gout
  VitaminDWiki suspects the link is low vitamin D - which is independently associated with both
• Epidemiology of gout has the following chart for the US

• Potential causal associations between vitamin D and uric acid: Bidirectional mediation analysis - 2015
   Download the interesting PDF from VitaminDWiki
• Search Google for GOUT CBD 1.1 million hits as of Aug 2017
  CBD = the legal form of Marijuana which reduces pain
• 25% Fewer gout flares if recently had Omega-3 fish and had also low purine diet - March 2019
  Effect of Dietary and Supplemental Omega-3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares, doi: 10.1002/art.40896
• Low levels of Lead (which also decrease VItamin D levels) increase gout Dr. Greger, 5 minute video Sept 2020
  • "More than 90% of the total body lead content resides in the bone, where the half-life is decades long,”
• Chronic Disease Approaches Needed to Curb Gout’s Growing Burden JAMA March 2018
  "Gout is common in the United States, affecting about 4% of adults."
  The word VITAMIN does not occur once in the PDF
   Download the PDF from VitaminDWiki

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Gout in the UK increased 20% in 3 years - Sept 2022

Victorian disease RETURNS to UK as NHS sees sudden surge and shares four warning signs Mirror
Also tuberculosis, malnutrition, whooping cough, measles, scurvy, typhoid, scarlet fever, diphtheria, mumps, rickets, cholera, and vitamin D deficiency

• note:Hyperlinks go to VitaminDWiki
• Gout, cholera, scarlet fever, TB all increasing in the UK (low vitamin D) – Feb 2019

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Gout, RA symptoms sometimes the same, sometimes different

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Gout epigenetics: Vitamin D, Vitamin D Receptor, Omega-3, etc - Sept 2022

 Download the PDF from VitaminDWiki

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7+ VitaminDWiki pages have GOUT in title

This list is automatically updated

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