Glyphosate and Vitamin D - many studies

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Overviews

• There are 31 items in Glyphosate category in VitaminDWiki
• Glyphosate [glahy-fos-eyt] is associated with many health problems
• Glyphosate reduces Vitamin D by both reducing CYP27A1 gene + many minerals needed by Vit. D
  VitaminDWiki suspects that Glyphosate is responsible for 10-20% of the decreased Vitamin D getting to cells
• Glyphosate is the only acknowledged active component of Roundup
  • However, Roundup is actually 125X more deadly to human cells than Glyphosate
• Many countries now ban Glyphosate
  • European Union as of Oct 25, 2017. China
  • Glyphosate (Roundup) increases risk of NH lymphoma by 41 percent – meta-analysis July 2019
  • It is still not banned in the US as of Sept 2023
• 45 studies of the health problems of Glyphosate - Nov 2024
  • Categories:Cancer; Epidemiology;Fertility, pregnancy and reproductive harms; Gut/inflammation; Neurologic damage/ Autism; Non-Hodgkins Lymphoma; Obesity; Organ damage/Other; Animals/Environment
• A crop can be called organic even if Roundup was only used to dry it (Wikipedia)
      wheat, oats, beans, lentil, sunflower, soy, rapeseed oil, etc
• You can compensate for Glyphosate by increasing your intake of
     Vitamin D, Magnesium, Boron, and Omega-3

      (More Glyphosate info below this box)

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Glyphosate causing 50% increase of liver problems - April 2025

• Report: Common weedkiller glyphosate may be linked to liver disease epidemic, study warns
• Study:Are glyphosate or glyphosate-based herbicides linked to metabolic dysfunction-associated steatotic liver disease (MASLD)? The weight of current evidence    Partial PDF is online
  • "Metabolic dysfunction-associated steatotic liver disease (MASLD) affects around 30 % of the world’s population, increasing its prevalence by 50 % in the last three decades"
  • Human urinary GLY levels are associated with different MASLD outcomes (steatosis risk, advanced fibrosis, increased transaminases) and comorbidities (higher risk for metabolic syndrome, diabetes, obesity and cardiovascular diseases) (6 studies).

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VitaminDWiki - Glysophate reduces Vitamin D in 9 ways

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Glyphosate increased all-cause mortality by 40 % (less Vitamin D to cells) – March 2025

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See also VitaminDWiki

• Huge increases in health problems – risk factors include Vitamin D, Antibiotics, and Roundup has the following graphic
  

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Glysophate in a dozen of gluten-free foods - Aug 2024

NaturalHealth365

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Glysophate increased risk of severe depression by 4X - Nov 2023

Association between glyphosate exposure and cognitive function, depression, and neurological diseases in a representative sample of US adults: NHANES 2013–2014 analysis

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Review Adds to Evidence That Glyphosate Weedkillers Cause Cancer - Aug 2023

The Defender

Evidence	Key characteristics of cancer-causing chemicals
Limited	Electrophilic (an affinity towards electrons) or metabolic activation (KC1).
Strong	Genotoxicity (KC2).
Limited	Alterations in DNA repair, causing genome instability (KC3).
Strong	Inducing epigenetic changes (KC4).
Strong	Inducing oxidative stress (KC5).
Strong	Inducing chronic inflammation (KC6).
Inadeguate	Immunosuppression (KC7).
Strong	Reducing receptor-mediated effects/endocrine disruption (KC8).
Inadequate	Immortalizing cancer cells (KC9).
Inadequate	Alterations in cell proliferation, death or nutrient supply (KC10)

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Glyphosate affects human bacteria, but probably not human cells - Mercola May 2023

Even Low Levels of Glyphosate Alter Your Gut Microbiota - Mercola includes 2 videos with references

• "Since mammals do not have the shikimate pathway, it was suggested that glyphosate would not affect human health. However, some microorganisms do have the shikimate pathway, and it’s via this link that many of glyphosate’s adverse effects in humans may occur. According to the study"

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New Research Links Glyphosate to DNA Damage, Cancer and Oxidative Stress - Jan 2023

The Defender

• "New research by top U.S. government scientists found that people exposed to the widely used weed-killing chemical glyphosate, a key ingredient in Monsanto’s Roundup weedkiller, have biomarkers in their urine linked to the development of cancer and other diseases."
• "The CDC reported that out of 2,310 urine samples taken from a group of Americans intended to be representative of the U.S. population, 1,885 were laced with detectable traces of glyphosate."
• "The EPA now is revisiting its glyphosate evaluation and expects to issue a decision for glyphosate in 2026."
  • Still being used in the US

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US court bands Dicamba (again) - Feb 2024

US court bans three weedkillers and finds EPA broke law in approval process

• "This is the second time a federal court has banned these weedkillers since they were introduced for the 2017 growing season. In 2020, the ninth circuit court of appeals issued its own ban, but months later the Trump administration reapproved the weedkilling products, just one week before the presidential election at a press conference in the swing state of Georgia."
• "Bury wrote that the EPA did not allow many people who are deeply affected by the weedkiller – including specialty farmers, conservation groups and more – to comment."
• "Syngenta is also facing nationwide litigation over its paraquat herbicide, which thousands of plaintiffs claim causes Parkinson’s disease.""

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Monsanto’s New Weed Killer, Dicamba, Divides Farmers - NYT Sept 2017

UNew York Times
The replacement may be worse than Roundup in many ways

1. More expensive
2. Damages trees in addition to killing weeds
3. Drifts farther
   "Because genetically modified crops allow dicamba to be sprayed later in the year, after crops emerge from the ground, and in hotter and more humid weather, the chemical is susceptible to what is known as “volatility” — it can turn into a gas and drift onto whatever happens to be nearby."
4. Health problems?
   "“For both dicamba and 2,4-D, the reproductive risks and birth defects” are “most worrisome.”

Update - Monsanto rewards farmers who use DiCamba Dec 2017

Farmers have been reluctant to use DiCamba (problems on own farm, neighboring farm, and state)
Monsanto now giving $5/acre reward if a farmer uses it (it costs $11/acre)
Farmers Incentivized With Cash to Spray New Poison Mercola

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Comparison of Health Problems: Glyphosate, Dicamba, and Diquat

PerplexityAI Deep Research June 2025

Herbicide	Key Health Problems
Glyphosate	- Neurotoxicity: Alters neurotransmission, induces oxidative stress, neuroinflammation, mitochondrial dysfunction, behavioral/motor disorders 1 14. - Liver and Kidney Damage: Linked to liver inflammation, metabolic dysfunction, non-alcoholic fatty liver disease (NAFLD), fibrosis; kidney damage at high doses 8 11 14. - Endocrine Disruption: Alters hormone levels, possible reproductive effects 2 14. - Gut Microbiome Disruption: Promotes dysbiosis, linked to inflammatory bowel disease, irritable bowel syndrome 11 14. - Cancer: IARC classifies as "probably carcinogenic to humans"; some regulatory agencies disagree 8 14.
Dicamba	- Acute Effects: Headache, dizziness, nausea, vomiting, muscle weakness, exhaustion; skin and eye irritation 3 4. - Cancer Risk: Increased risk of liver and intrahepatic bile duct cancer, chronic lymphocytic leukemia (CLL), acute/other lymphocytic leukemia in high-exposure groups; some studies show mixed results for lung/colon cancer 9 12 17. - Liver and Kidney Effects: Laboratory studies suggest possible liver and kidney damage, but less evidence than for glyphosate or diquat 15 17. - Endocrine and Reproductive Effects: Limited evidence for reproductive harm; some studies suggest increased odds of hypothyroidism 3 15.
Diquat	- Acute Poisoning: Severe mucosal damage (mouth, esophagus, stomach, intestines), vomiting, diarrhea, pain, multi-organ failure (kidney, liver, heart, lungs) 5 10 13. - Kidney Damage: Acute tubular necrosis, renal failure, proteinuria, hematuria 5 6 10. - Liver Damage: Jaundice, liver lesions, mitochondrial dysfunction, cell death 5 7 13. - Neurological Effects: Nervousness, irritability, seizures, coma, encephalopathy 5 10. - Gut Barrier Dysfunction: Disrupts intestinal barrier, reduces beneficial bacteria, increases inflammation, impairs nutrient absorption 7 13. - Multi-Organ Dysfunction: Can trigger systemic inflammation and multiple organ failure (MODS) 13. - Cancer: Not classified as a carcinogen, but severe toxicity is well-documented 5 13.

Summary Table

Herbicide	Neurotoxicity	Liver/Kidney Damage	Cancer Risk	Endocrine/Reproductive	Gut Health	Multi-organ Failure
Glyphosate	Yes	Yes	Probable	Yes	Yes	No
Dicamba	Mild/acute	Possible	Increased (liver, CLL)	Possible (hypothyroidism)	No data	No
Diquat	Yes (severe)	Yes (severe)	No	No data	Yes (severe)	Yes

Key Points

• Glyphosate: Most widely studied; neurotoxic, liver/kidney damage, endocrine disruption, gut microbiome effects, and possible carcinogenicity are major concerns. Effects can occur at doses below regulatory limits 1 8 11.
• Dicamba: Acute toxicity is generally mild, but long-term exposure is associated with increased risk of certain cancers (especially liver and bile duct cancers and lymphocytic leukemia). Evidence for liver/kidney and endocrine effects is emerging but less robust 9 12 15.
• Diquat: Highly toxic upon ingestion, causing severe gastrointestinal, renal, hepatic, neurological, and multi-organ damage. Not considered a carcinogen, but acute poisoning is often fatal or leads to long-term organ dysfunction 5 6 13.

Conclusion
Glyphosate is notable for chronic, multi-systemic health risks including possible cancer and widespread organ effects. Dicamba is associated with certain cancers in high-exposure groups and some acute symptoms, but its overall toxicity profile is less severe than glyphosate or diquat. Diquat is extremely toxic in acute exposures, causing rapid multi-organ failure and death, but is not linked to cancer. All three herbicides require careful handling and further research to clarify long-term risks, especially in vulnerable populations.
References

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC9101768/
2. https://www.atsdr.cdc.gov/toxprofiles/tp214-c2.pdf
3. https://nj.gov/health/eoh/rtkweb/documents/fs/0634.pdf
4. https://npic.orst.edu/factsheets/dicamba_gen.html
5. https://pmc.ncbi.nlm.nih.gov/articles/PMC9030962/
6. https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.991587/full
7. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1562182/full
8. https://publichealth.berkeley.edu/articles/spotlight/research/childhood-exposure-to-common-herbicide-may-increase-the-risk-of-disease-in-young-adulthood
9. https://pmc.ncbi.nlm.nih.gov/articles/PMC7660157/
10. https://pmc.ncbi.nlm.nih.gov/articles/PMC9399667/
11. https://usrtk.org/pesticides/glyphosate-health-concerns/
12. https://pubmed.ncbi.nlm.nih.gov/32357211/
13. https://usrtk.org/healthwire/diquat-herbicide-poisons-the-gut-may-severely-damage-other-organs/
14. https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2024.1474792/full
15. https://usrtk.org/pesticides/dicamba/
16. https://www.epa.gov/sites/default/files/documents/rmpp_6thed_ch12_paraquatdiquat.pdf
17. https://beyondpesticides.org/dailynewsblog/2020/05/study-finds-an-association-between-dicamba-use-and-increased-risk-of-developing-various-cancers/
18. http://npic.orst.edu/factsheets/glyphogen.html
19. https://www.webmd.com/cancer/herbicide-glyphosate-cancer
20. https://www.epa.gov/ingredients-used-pesticide-products/glyphosate
21. https://pubmed.ncbi.nlm.nih.gov/32203845/
22. https://beyondpesticides.org/dailynewsblog/2024/03/epa-and-court-allow-violations-and-hazards-of-weed-killer-dicamba-under-existing-stocks-order/
23. https://npic.orst.edu/factsheets/archive/dicamba_tech.html
24. https://www.audubon.org/magazine/weedkiller-dicamba-poisoning-wildlife-habitat-will-epa-finally-act
25. https://pirg.org/articles/the-toxic-pesticide-dicamba-is-a-threat-to-crops-and-human-health-its-time-to-ban-it/
26. https://www.nj.gov/health/eoh/rtkweb/documents/fs/0808.pdf
27. https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-032201_1-May-02.pdf
28. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00339-X/fulltext
29. https://ontosight.ai/glossary/term/diquat-toxicity-and-its-effects67a0dbca6c3593987a503e6f
30. https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-417300_1-Sep-93.pdf

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Review of 100 studies on health problems of Diquat - May 2025

Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies
Front. Pharmacol., 11 May 2025 Volume 16 - 2025 | https://doi.org/10.3389/fphar.2025.1562182
 Download the PDF from VitaminDWiki

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The TOXIC Truth About Glyphosate - 100 minute video - May 2025

YouTube

Background & Motivation (00:00-15:00)
Zen Honeycutt, founder of Moms Across America, started as a fashion designer but became a food activist after her children developed 20+ food allergies and autism symptoms
Her awakening came from watching Jeffrey Smith's "Genetic Roulette" and Robyn O'Brien's TED talk about GMOs, realizing her children's health issues were likely connected to genetically modified foods
She felt deeply betrayed learning that 80-95% of major crops (corn, soy, canola, sugar beets) were GMO without proper labeling

Birth of Moms Across America (15:00-25:00)
After California's Prop 37 GMO labeling initiative failed in 2012, Honeycutt had a "white light moment" in the shower envisioning nationwide Fourth of July parades to educate about GMOs
Within 3 months, they had 300,000+ weekly Facebook reach with only 3,000 likes and organized 179 groups in parades across all 50 states
Monsanto responded aggressively - internal documents later revealed they said "we need to beat the shit out of these moms" and hired 250+ trolls to attack activists

Corporate Attacks & Testing (25:00-45:00)
Honeycutt faced severe harassment including fake social media profiles, planted informants in mom groups, and personal attacks on her family and funding
She initiated glyphosate testing in 2014, finding it in 70-90% of urine, tap water, and breast milk samples - one mother had 3,000x the safe level in breast milk
At the 2016 Monsanto shareholder meeting, she confronted CEO Hugh Grant, asking shareholders to consider if their investments would prevent their grandchildren from having children

Health Impacts of Glyphosate (45:00-1:20:00)
Glyphosate is an antibiotic that destroys gut bacteria (Americans now have ~10,000 bacterial species vs. the normal 30,000)
It's also a chelator that removes 20-85% of nutrients from plant roots and 80-95% from shoots (the part we eat), creating nutrient-deficient food
Recent testing found 93% of school lunch samples and 100% of fast food samples positive for glyphosate, plus heavy metals 6,000x EPA limits for drinking water
A drug causing aggression was found in 47% of top fast food samples, potentially contributing to violence and school shootings

Current Strategy & MAHA Partnership (1:20:00-end)
With RFK Jr. as HHS Secretary, there's unprecedented opportunity - they're testing vaccines for glyphosate and examining food ingredients
Honeycutt is partnering with ICAN on "Make America Healthy Again" community events planned for October 18th (National Children's Health Month)
The plan involves Fourth of July parades reaching thousands, followed by local organizing events to build healthier communities
Two states (North Dakota and Georgia) have already passed laws giving chemical companies complete immunity from lawsuits - a major threat requiring urgent action

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Reduce minerals such as Zinc and Magnesium needed by Vitamin D

• Glyphosate reduces the amount of iron, manganese, zinc, and boron which a plant can get from the soil all of which are important to Vitamin D
• EPA scientist warns that glyphosate (RoundUp) herbicide strips minerals out of food, leaving the body deficient in Zinc and Magnesium March 2017
• Interaction of Glyphosate with Zinc for the Yield, Photosynthesis, Soil Fertility and Nutritional Status of Soybean Feb 2016

See also web - banned in 70+ countries, but not the US (yet)

• Where is Glyphosate Banned? May 2023 >70 countries, but not the US
  • "Bayer Will Stop Selling Glyphosate in U.S. Lawn & Garden Market Starting in 2023"
• GMO crops totally banned in Russia... Sept 2015
  share of GMO in the Russian food industry has declined from 12 % to just 0.01 % in 10 years
• A Complete List Of All Countries That Have Banned Glyphosate 2016
  Malta., Sri Lanka. The Netherlands, Argentina
• Where is Glyphosate Banned? sometime before Oct 2017
  Argentina, Australia, Belgium, Bermuda. Brazil?, Canada, Colombia, El Salvador, England - townships, France -2022 private sale, Germany - not to renew the license for glyphosate. Italy restrictions, Netherlands, New Zealand Auckland and Christchurch -in public places, Spain: Barcelona, Madrid . . banned the use of glyphosate in public areas, +Sri Lanka: Banned the private and commercial sale of glyphosate.
• French MEP: Difficult but possible to find glyphosate alternative in 5 years
  "With 355 votes in favour, 204 against and 111 abstentions, the European Parliament stressed on 24 October (2017) that a full ban on glyphosate-based herbicides should be imposed by December 2022, and endorsed immediate restrictions on the use of the substance."
  "Particularly, EU lawmakers asked for an immediate ban for non-professional use and use in public parks, gardens and playgrounds, and a five-year phasing-out period for all agricultural use."

See other web

• Glyphosate & Roundup Inhibit Vitamin D And Cause Nutritional Deficiencies MyBiohack Date?
• Folic Acid and Glyphosate STEPHANIE SENEFF, PHD, May 2016
  Glyphosate may reduce Folate production in the gut
• How concerned should I be about glyphosate in foods and supplements? Consumer Labs Nov 2017
  " . .genetically modified (GMO) soybeans and corn. It is also sprayed on many types of conventional crops such as wheat, oats, and barley prior to harvest as a drying agent and to even-out maturity. A USDA study in 2012 found that it was also commonly used on cherries, avocados, apples, lemons, grapefruit, peanuts, pecans, and walnuts "
  "Glyphosate is also found in processed foods containing these ingredients cannot be removed by washing, cooking, or baking. It can remain stable in food for a year or more. "
  In many oat cereals, but " no detectable glyphosate in the organic oats it tested from Bob's Red Mill, 365 Whole Foods, Sprout, or Nature's Path. "
• Crop desiccation Wikipedia
  " . . in the UK 78% of oilseed rape is desiccated before harvest, but only 4% in Germany"
• Whitewash: The Story of a Weed Killer, Cancer, and the Corruption of Science Amazon $16 Dec? 2017
  Mothers Nature Network has lengthy description
  "So, there are a number of different uses and a number of different applications. It’s used in our citrus groves in Florida. The farmers there are spraying it around the root structure to try and keep weeds from competing for things like moisture and nutrients. The science on that I have read … is more the impact on the soil because glyphosate kills the beneficial microbes in the soil that help the plant to remain healthy. So, when you’re killing those beneficial microbes in the soil, the plant is more susceptible to disease, or perhaps needs more fertilizer,"
  "There currently are about 3,500 plaintiffs who are suing Monsanto, alleging specifically that Roundup gave them non-Hodgkin lymphoma (NHL) and that Monsanto knew and covered up the risks."
  "‘Whitewash’ has been compared to Rachel Carson’s book ‘Silent Spring,’ which 55 years ago alerted the world to the dangers of unchecked pesticide use, particularly DDT, and launched the modern environmental movement."
• Monsanto hit list exposed Mercola Aug 2019
  • "Documents obtained during the discovery process of lawsuits against Monsanto..."
  • "Monsanto planned to discredit Gillam’s book, “White Wash” ahead of its release in 2017 by instructing its customers to post negative reviews and paying Google to promote search results critical of Gillam and her work"

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Perhaps can flush Glyphosate from body with high-dose Glyscene for a few months

Top Tips to Detox Your Body Mercola Jan 2019

• "To eliminate glyphosate, you need to saturate your body with glycine. Klinghardt recommends taking 1 teaspoon (4 grams) of glycine powder twice a day for a few weeks and then lower the dose to one-fourth teaspoon (1 gram) twice a day. This forces the glyphosate out of your system, allowing it to be eliminated through your urine."
• "I personally have been taking 1 gram twice a day for some time now. The glycine is inexpensive and actually tastes sweet. Ideally it is best to take it around the time you are eating food that might be contaminated with glyphosate."
• quote from expert
  • "At least for a while, we use high doses of glycine. There are no issues with it. There are no problems with it. The other one that has been published is admittedly only a chicken study that shows that humic acid and fulvic acid can completely clean up the organ systems of a chicken …
  • "So, we do the glycine for a while. We monitor the urine output of glyphosate. When that slows down — in some people two months, in some it's six months — we back off on the glycine and go on a smaller dose."

Why You Need Glycine: A Panel Discussion Masterjohn Jan 2018

• Podcast with transcript

Chart from South Africa

Glycine is molecularly very similar to Glyphosate

23 Proven Benefits of Glycine Supplements + Glycine Foods SelfHacked April 2016

Glyphosate pretending to be Glycine - devestating consequences Slideshare - Seneff April 2017
Example of many charts showing strong associations between increased health problems and Increased Glyphosate

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31 items in Glyphosate category in VitaminDWiki

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