Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis

Created July 2018

Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis.

Medicine (Baltimore). 2018 Jul;97(29):e11506. doi: 10.1097/MD.0000000000011506.

Zhang JZ1, Wang M2, Ding Y1, Gao F2, Feng YY1, Yakeya B1, Wang P1, Wu XJ1, Hu FX1, Xian J3, Kang XJ1.

1 Department of Dermatology.

2 Department of Gastroenterology.

3 Department of Gynecology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.

* Vitiligo is associated with low vitamin D (nothing about treatment) – meta-analysis March 2016 * Vitamin D Receptor in vitiligo skin activated by UVB – May 2018 * Spotty skin coloring (vitiligo) treated by augmenting topical tacrolimus with oral Vitamin D – Oct 2016 * Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014 * Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018 -Note: Vitiligo is an auto-immune disease --- 1. See also web Subsequent Meta-analysis of Vitiligo and vitamin D in blood found a much smaller assocation Decreased circulatory levels of Vitamin D in Vitiligo: a meta-analysis - 2021 * *📄 Download the PDF from VitaminDWiki * --- 1. Observation by Henry Lahore, Founder of VitaminDWiki Increased risk of Vitiligo if: Low Vitamin D in blood AND/OR Poor Vitamin D Receptor which restricts Vitamin D getting to skin cells SOLUTIONS: Increase intake of Vitamin D Increase Sun/UVB Increase VDR activation (see below) 1. Autoimmune category starts with {include} --- 1. Vitamin D Receptor category has the following {include}

📄 Download the PDF from VitaminDWiki

OBJECTIVES: To explore the relationship among the vitamin D receptor (VDR) gene polymorphisms, serum 25-hydroxyvitamin D levels, and vitiligo.

METHODS:

Databases including PubMed, Cochrane Library, Ovid, Web of Science, CNKI, SinoMed, and Wanfang Data were systematically searched. The association was assessed using odds ratios (ORs), standard mean difference (SMD), and 95% confidence intervals (CIs). The statistical tests were performed using Review Manager 5.3.3.

RESULTS:

We identified a total of 17 studies. The relationship between VDR gene polymorphisms (BsmI, ApaI, TaqI, and FokI), serum 25 (OH)D levels, and incidence of vitiligo was investigated. The results of this meta-analysis showed that the

  • dominant genetic model (CC+AC vs AA, P = .007, OR = 1.41, 95% CI = 1.10-1.80),

  • recessive genetic model (CC vs AC+AA, P = .01, OR = 4.10, 95% CI = 1.36-12.35), and

  • allelic contrast model (C vs A, P = .005, OR = 1.87, 95% CI = 1.21-2.90)

  • of VDR Apal locus increased the risk of vitiligo, and BsmI, TaqI, and FokI loci and the risk of vitiligo have no obvious correlation.

Serum 25 (OH)D deficiency was positively associated with the incidence of vitiligo (P < .0001, SMD = -0.94, 95% CI = -1.39, -0.48).

CONCLUSION:

This meta-analysis revealed that VDR Apal polymorphism increased the susceptibility risk of vitiligo, and there is a positive correlation between serum 25 (OH)D deficiency and the incidence of vitiligo.

Tags: Autoimmune Meta-analysis Skin Vit D Receptor