Vitamin D and the Liver – Is it Correlation or Cause

Created April 2018

Nutrients 2018, 10(4), 496; doi:10.3390/nu10040496

(This article belongs to the Special Issue Changing Times for Vitamin D and Health)

* Weekly dosing of vitamin D is far better than single large dose (chronic liver, children) – March 2018 * Weekly dosing is looking very promising for many health problems - April 2018 * Liver, Liver Cancer, and Vitamin D – Feb 2018 * NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016 * Non-Alcoholic Fatty Liver Disease treated by Omega-3 – three meta-analysis 2016-2017 * Not Vitamin D monotherapy --- Items in both categories Liver and Intervention are listed here: give vitamin D and see what happens {category} --- Items in both categories Liver and Meta-analysis are listed here: summary of trials {category}

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Table 1. Potential direct and indirect mechanisms of effect of vitamin D in liver diseases.

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Table 2. Selected intervention studies in liver disease and study parameters

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Jeremy T. Keane 1, Harendran Elangovan 2, Rebecca A. Stokes 1,2 and Jenny E. Gunton 1,2,3,

  • 1 Centre for Diabetes, Obesity & Endocrinology, The Westmead Institute for Medical Research (WIMR), Westmead, Sydney, NSW 2145, Australia

  • 2 The Garvan Institute of Medical Research, The University of New South Wales (UNSW), Darlinghurst, Sydney, NSW 2010, Australia

  • 3 Faculty of Medicine and Health, The University of Sydney, Westmead Hospital, Westmead, Sydney, NSW 2145, Australia

Vitamin D is becoming increasingly accepted as an important physiological regulator outside of its classical role in skeletal homeostasis. A growing body of evidence connects vitamin D with hepatic disease. This review summarises the role of vitamin D in liver homeostasis and disease and discusses the therapeutic potential of vitamin D-based treatments to protect against hepatic disease progression and to improve response to treatment. While pre-clinical experimental data is promising, clinical trials around liver diseases have mostly been under-powered, and further studies will be required to clarify whether vitamin D or vitamin D analogues have beneficial effects on liver disease.

Tags: Liver