Urate (kidney stones, gout) reduced by Calcium – RCT
Urate-lowering effect of calcium supplementation: Analyses of a randomized controlled trial
Clin Nutr ESPEN. 2022 Jun;49:86-91. doi: 10.1016/j.clnesp.2022.02.121 behind $$ paywall
Flávia Galvão Cândido 1, Raquel Duarte Moreira Alves 2, Dayse Mara de Oliveira Freitas 2, Jersica Martins Bittencourt 2, Daniela Mayumi Usuda Prado Rocha 2, Rita de Cássia Gonçalves Alfenas 2
Objective: To investigate if the gout-protective effect of low-fat dairy products could be attributed to the urate-lowering effect of calcium.
Methods: This is a placebo-controlled trial in which thirty-five adult (aged 18-42 years) female low-calcium consumers (<800 mg/d) were randomized to one of three treatment groups: low calcium breakfast (control, ∼70 mg of calcium/d) -C or high-calcium breakfast (∼770 mg/d) from calcium citrate - CIT or from skim milk - SM, during 45 consecutive days. Breakfasts were matched for potential confounders and were provided as part of an energy-restricted normoprotein diet containing an additional 800 mg of calcium/d. Dual-energy X-ray absorptiometry measurements (body fat assessment) and fasting blood samples (urate, ionic calcium, PTH, and 1,25-(OH)2-D3) were taken at baseline and the end of the experiment.
Clinical trial registration: http://www.ensaiosclinicos.gov.br/ (RBR-7Q2N33).
Results: Despite no significant changes in total body weight/fat, CIT and SM led to a significant reduction in serum urate and ionic calcium, but did not affect PTH and vitamin D concentrations compared to C. CIT and SM reduced baseline serum urate by ∼14% and ∼17%, respectively. There was a trend to a positive correlation between changes in serum urate and changes in ionic calcium on day 45 (r = 0.327, P = 0.055).
Conclusions: Calcium supplementation (770 mg/d from dairy or calcium citrate) reduced serum urate concentrations, suggesting that the gout-protective effect of low-fat dairy consumption is at least partly due to a urate-lowering effect of calcium.
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Etc
VitaminDWiki - Gout and Vitamin D - many studies contains
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VitaminDWiki - Overview Kidney Stones and vitamin D studies
VitaminDWiki - Overview Calcium studies
Note: A vegi-calcium supplement appears to be much better than a rock-Calcium supplement