T2 Diabetes might be fought by Vitamin D plus Vitamin D Receptor activators
Vitamin D in Diabetes: Uncovering the Sunshine Hormone's Role in Glucose Metabolism and Beyond
Nutrients 2023, 15, 1997. https: / / doi.org/ 10.3390/nu15081997
Jie Wu 1 , Annette Atkins 2, Michael Downes * and Zong Wei 1,3,*
Department of Physiology and Biomedical Engineering, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Division of Endocrinology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
- Correspondence: downes@salk.edu (M.D.); wei.zong@mayo.edu (Z.W.)
Over the last decades, epidemiology and functional studies have started to reveal a pivotal role of vitamin D in both type 1 and type 2 diabetes pathogenesis. Acting through the vitamin D receptor (VDR), vitamin D regulates insulin secretion in pancreatic islets and insulin sensitivity in multiple peripheral metabolic organs. In vitro studies and both T1D and T2D animal models showed that vitamin D can improve glucose homeostasis by enhancing insulin secretion, reducing inflammation, reducing autoimmunity, preserving beta cell mass, and sensitizing insulin action.
Conversely, vitamin D deficiency has been shown relevant in increasing T1D and T2D incidence. While clinical trials testing the hypothesis that vitamin D improves glycemia in T2D have shown conflicting results, subgroup and meta-analyses support the idea that raising serum vitamin D levels may reduce the progression from prediabetes to T2D.
In this review, we summarize current knowledge on the molecular mechanisms of vitamin D in insulin secretion, insulin sensitivity, and immunity, as well as the observational and interventional human studies investigating the use of vitamin D as a treatment for diabetes.
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Risk of 44+ diseases at least double with poor Vitamin D Receptor
81+ Vitamin D Receptor pages in VitaminDWiki have CANCER in title
14 ways Vitamin D Receptor activation can be increased
Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators
VitaminDWiki - The Vitamin D Receptor is associated with many health problems contains
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VitaminDWiki - studies in both categories Diabetes and Vitamin D Receptor
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6 Reasons that medical professionals do not prescribe Vitamin D for Diabetes
- No profit for Big Pharma
Less income for doctors or hospitals if stop diabetes
The Vitamin D dose needed often varies by 4X between individuals for many health problems
- Doctors prefer using a single dose of a drug for all patients
- Doctors are unaware that small doses of vitamin D gut-friendly can be used
- Gut-Friendly Vitamin D is available on Amazon, but not in pharmacies, nor by prescription
- they are uncomfortable prescribing 4,000+ IU of vitamin D
- in many countries, doctors can only prescribe D2 (which does not work as well), not D3
- Doctors are unaware that adding Magnesium helps prevent/treat Diabetes
- they often just want to use a monotherapy
- Doctors are unaware that sometimes the Vitamin D Receptors also need to be activated