Surgeries to re-establish blood in brain, heart, etc. are far more successful with high Vitamin D levels
A review on the effects of vitamin D attenuating ischemia reperfusion injuries
INTERNATIONAL JOURNAL OF FOOD PROPERTIES 2022, VOL. 25, NO. 1, 522-540 https://doi.org/10.1080/10942912.2022.2052084
Chaoran Chen a, Xiao Wan a*, Jia Shangb, Wunong Zhangc, and Zhenxing Xied
a institute of Nursing and Health, College of Nursing and Health, Henan University, Kaifeng, HN, China;
b Arts department, School of Kaifeng Culture and Tourism, Kaifeng, HN, China;
c College of Educational Sciences, Henan University, Kaifeng, HN, China;
d School of Basic Medical Sciences, Henan University, Kaifeng, HN, China
PDF Table of contents

Ischemia reperfusion (I/R) injuries occurred in many pathological and surgical processes (e.g. thrombolytic therapy, organ transplantation, aortic crossclamping, coronary angioplasty and cardiopulmonary bypass) and harmed multiple organs and tissues. Vitamin D is a well-known sterol hormone and a nutritional ingredient able to promote the deposit of calcium and regulate phosphorus metabolism in the body. In addition, vitamin D has therapeutic effects on some diseases (e.g. cardiovascular disease, diabetes, cancer, neurological diseases, multiple sclerosis and inflammation).
Studies showed that vitamin D3 was closely related with I/R injury occurrences in
heart,
brain,
Spine,
liver,
kidney, and
ovary.
The literature searching was conducted in PubMed, Embase, Cochrane Library, Web of Science, and SCOPUS from inception to 20 September 2021.
Data showed that supplements with vitamin D3 can remarkably attenuate I/R injuries. This paper reviewed recent progresses of vitamin D3 preventing I/R injuries in clinical investigations and animal tests to enlighten future studies.

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